Five patients with nonseptic cerebral embolism of cardiac origin are reported in whom early anticoagulant therapy resulted in clinical deterioration or death from frank hemorrhage into the acute infarct. In each patient an initial CT scan excluded the presence of intracerebral hemorrhage and a second CT scan, after clinical deterioration had occurred, documented frank hemorrhage into the infarcted zone. All five patients had large infarctions in the right middle cerebral artery territory and three patients were mildly hypertensive. Four patients received heparin within 36 hours of their stroke and one was on warfarin at time of the embolism. Clinical deterioration occurred after intervals of several hours (2 cases), 5-6 days (2 cases) and 30 days (1 case). In only 2 patients was anticoagulant activity excessive at time of clinical deterioration. This report illustrates the danger of early anticoagulant therapy of acute nonseptic cerebral embolism, particularly in the setting of large infarction.

Acute Disease↗

PubMedDate not supplied

The irrelevance of mammillary body lesions in the causation of the Korsakoff amnesic state.

This discussion has been concerned with one small corner of the anatomy of memory, namely, with the role of mammillary body lesions in the causation of the Korsakoff amnesic state. Clinical-pathologic studies, both our own (of alcoholics with the Wernicke-Korsakoff syndrome) and those of others (in patients with thalamic infarctions and neoplasms) provide unambiguous evidence that medial thalamic lesions, without additional lesions of the mammillary bodies, are quite sufficient to produce a severe and enduring amnesic state. Behavioral abnormalities in animals, insofar as they can be equated with a defect in retentive memory, tend to substantiate the observations in humans.

Alcohol Amnestic Disorder↗

PubMedDate not supplied

[pH values in dental pulp gangrene].

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Aerobiosis↗

PubMedDate not supplied

[Uncombable hair syndrome. Pili trianguli et canaliculi (author's transl)].

We present a general review of a new syndrome that we described in 1973, under the title "cheveux incoiffables" (uncombable half syndrome). The scanning electron microscopy shows two specific alterations of the hair: a triangular section and a longitudinal groove.

Child↗