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Biomedical subjects

M Verma

Publications and source records attributed to M Verma.

At least 145 records · Page 8Linked to original sources
PubMed1985

Bacteriophage P22 helps bacteriophage MB78 to overcome the transcription inhibition in rifampicin resistant mutant of Salmonella typhimurium.

Bacteriophage MB78 cannot grow on rifampicin resistant mutant of host Salmonella typhimurium (rif39) which contains an altered beta subunit of RNA polymerase. Bacteriophage P22, however, grows normally in rif39 both in the presence or absence of rifampicin. Perhaps MB78 promoter is not recognized by altered RNA polymerase. As the phage P22 helps MB78 to grow to some extent on rif39, hybrids between P22 and MB78 have been isolated. Hybrid phage which can grow on rif39 contains mostly genes from MB78 although a small portion (15-20 per cent) of the genome belongs to P22 genome which helps MB78 to overcome the transcription inhibition in the host mutant with altered RNA polymerase.

DNA-Directed RNA Polymerases↗
PubMed1984

Anti-inflammatory activity of amino acyl benzoates.

Nineteen new piperazino or morpholino amino acyl benzoates were synthesized and screened against carrageenin induced oedema in albino rats. Several compounds of the series showed potent anti-inflammatory activity. Compound 10 was found to be the most potent. This compound was further evaluated in detail and compared with phenylbutazone for its relative anti-inflammatory potency and ulcerogenic liability. The compound, in addition, was compared with acetyl salicylic acid for its analgesic activity. This compound showed potent ant-inflammatory activity with minimal ulcerogenic liability.

Aminobenzoates↗
PubMed1982

Participation of the host protein(s) in the morphogenesis of bacteriophage P22.

Spontaneous mutants of S. typhimurium resistant to thiolutin are conditionally non-permissive for phage P22 development (Joshi and Chakravorty 1979). At 40 degree C non-infective phage particles are produced. Phage development in two nonpermissive hosts (18/MC4 and 153/MC4) has been studied in detail. The steps at which the phage morphogenesis is interfered with differ in the two mutants. The electron micrograph of the particles produced in the mutant 18/MC4 reveals the presence of normal-looking particles; these particles contain phage DNA, adsorb to the permissive host but fail to inject their DNA. The particles produced in the mutant 153/MC4 which fail to adsorb to the host are found to be tail fibre-less. These observations indicate the involvement of host protein(s) in phage P22 morphogenesis.

Bacterial Proteins↗
PubMed1982

Thiolutin-resistant mutants of Salmonella typhimurium.

Spontaneous mutants of Salmonella typhimurium isolated in our laboratory from thiolutin-containing tryptone agar plates are partially resistant to thiolutin in enriched media. In minimal media, they are not resistant. The mutants are not temperature sensitive but fail to support the development of phage P22 at higher temperatures (40 degrees C). Thiolutin did not interfere with RNA polymerase or nucleotide kinase in in vitro experiments. However, thiolutin did inhibit the rate of incorporation of exogenous uridine into the cellular pool and consequently the acid-precipitable material. It appears that one site of action of thiolutin is at the membrane level.

Anti-Bacterial Agents↗
PubMed1982

Investigation of lymphocyte subpopulations and hypersensitivity skin tests during the menstrual cycle and pregnancy.

Cell-mediated immune responses were examined during the menstrual cycle of 10 healthy females and in 90 pregnant females, 10 for each month of gestation, and in 10 females 2--4 weeks after normal delivery. Lymphocytes and their subpopulations and PPD hypersensitivity skin tests were investigated. The lymphocyte subpopulation T-cells showed statistically significant depression at the time of ovulation (P less than 0.01) and during the entire period of gestation (P less than 0.001) with recovery in the post-partum period. There was borderline PPD skin response during pregnancy which became positive after parturition. These changes were demonstrated to be specific to conception but the exact mechanism of the T-cell depression is not known. There was a corresponding rise in the B-cell count.

Adolescent↗
PubMed1981

Simultaneous bilateral central dislocation of the hip--an unusual complication of eclampsia.

Bilateral hip injuries are rare. A case of bilateral central dislocation of the hip caused by eclamptic convulsions is reported because of its rarity. Further, eclampsia as a cause of bilateral central dislocation has not been reported earlier. All the earlier 11 cases were due to therapeutic convulsions before 1960. The patient reported here was ambulatory 6 months after injury, with some restriction of rotation and abduction.

Adult↗
PubMed1978

The forensic laboratory evaluation of evidence in alleged rape.

Serial vaginal fluid samples were obtained for laboratory analysis in 15 couples after voluntary intercourse. These samples were analyzed to determine the rate of decay of sperm and prostatic acid phosphatase as it pertains to alleged rape. An attempt was made to identify the male partner by laboratory examination of pubic hair combings and for foreign ABO antigens in vaginal fluid. If consideration is given to proper laboratory controls, examination for spermatozoa and prostatic acid phosphatase remains the primary test in alleged rape.

ABO Blood-Group System↗