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Biomedical subjects

M Verhas

Publications and source records attributed to M Verhas.

At least 37 records · Page 2Linked to original sources
PubMed1987

Predictors of the variation of the ejection fraction during exercise in patients with and without coronary heart disease.

The aim of this study was to determine the factors influencing the different response of the ejection fraction (EF) of the left ventricle at exercise observed in patients with and without significant coronary heart disease. We have studied 98 patients referred for coronary angiography (82 men, 16 women), of whom 49 patients had a previous myocardial infarction and 71 patients had significant coronary heart disease. Exercise testing was performed and combined with a cardiac blood pool imaging at equilibrium. The variation of the EF between rest and peak exercise (delta EF) was measured. Twelve clinical, exercise-related, isotopic, and coronary arteriographic variables were examined in a linear univariate and statistical analysis. In the univariate regression, seven variables were significant regressors on the delta EF. In the multivariate regression, only four variables were significant regressors on the delta EF. Three independent predictors were found: the rate-pressure product, the ST depression, and the occurrence of a previous myocardial infarction. These three independent predictors reflect the myocardial functional reserve.

Coronary Disease↗
PubMed1986

The effect of orchidectomy on bone metabolism in aging rats.

We have shown that orchidectomy in postpubertal 55-day-old rats led beyond 2 months to a decrease in bone growth and loss of weight. At 1 month postorchidectomy, we observed a three-fold increase in bone blood flow, an increase in calcium accretion rate, and an increase in the number of osteoclasts in the metaphysis. In the present experimental study, orchidectomy was performed in 1-year-old rats when bone growth in length was no longer measurable. In the tibia and femur we observed a decrease in bone volume, a still more rapid decrease of bone calcium during the first postoperative month, a thinning of the cortical width, an initial increase in calcium accretion rate (+20% when compared to 31 days controls) followed by a decrease at 120 days (-22% and -11% when compared to controls for tibia and femur respectively), a 29% increase in bone blood flow, and an increase in the number of osteoclasts. We conclude that androgen deprivation in young and old animals leads to a modified bone architecture, independent of the androgen impact on bone growth.

Animals↗
PubMed1985

Prognostic value of computed tomography in aphasic stroke patients.

In order to evaluate the prognostic value of CT scan in aphasic stroke patients, a prospective study was performed during the first 3 months of the disease. The severity of the language disorders was assessed by means of a quantitative method. In cortico-subcortical lesions, the verbal expression recovery rate and the final verbal expression and comprehension status depended on the infarct size. No relation was observed between the latter and the verbal comprehension recovery rate. In deep-seated lesions, computed tomography provided no information concerning the prognosis.

Aged↗
PubMed1984

Uptake of colloids by bone is dependent on bone blood flow.

In rat the uptake of colloids by the femur and tibia is dependent on bone plasma flow even if other factors modulate the relationship. We warn Nuclear Medicine scientists against the use of colloid uptake measurement as a marker of the bone macrophagic population, especially in situations associated with modified bone plasma flow.

Animals↗
PubMed1984

Resting CBF sequential study during recovery from aphasia due to ischemic stroke.

Cerebral blood flow (133Xenon inhalation method) has been studied in 30 aphasic stroke patients at 15, 30, 60 and 90 days after onset. In total aphasia the CBF values are low and the regional hypoperfused areas are extensive. In Broca's, Wernicke's and nominal aphasias, resting CBF measurements do not provide the clinician with useful additional information and clinical improvement can by no means be attributed to a resting CBF rise during the observation period.

Adult↗
PubMed1984

Growth and bone haemodynamic responses to castration in male rats. Reversibility by testosterone.

Orchidectomy in postpubertal 55 day old rats, compared to sham-operated controls, led beyond 2 months to a decrease in body weight (87% of controls by 120 d), tibial length (97% of controls) and in tibial calcium content (85% of controls). Bone plasma flow increased three times to reach a peak at 31 days; it was decreased but no significantly at 86 and 120 days. The number of osteoclasts was maximal at 51 days (X 2.3) and was still elevated at 120 days. The calcium accretion rate increased briefly at 31 days (110% of controls) and was diminished at 86 and 120 days (78% of controls). The initial 'physiological' changes in the tibia occurred before any weight change and might be directly due to the lack of androgens. They can be interpreted as inducing the conditions for enhanced bone resorption. Testosterone replacement therapy, initiated after the initial haemodynamic response, inhibited the negative effect of castration on bone growth.

Age Factors↗
PubMed1982

Effects of oxygen breathing on regional distribution of ventilation and perfusion in hypoxemic patients with chronic lung disease.

Regional distribution of ventilation and perfusion were measured in 17 hypoxemic and 16 normoxic patients using 13N as tracer. The effect of 100% and 50% O2 breathing was tested. No variation was observed in normoxic patients. In hypoxemic patients, perfusion was not modified significantly during O2 breathing. Poorly-ventilated zones hypoventilated even more during O2 breathing. It is suggested that this effect may have been due to (1) a collapse of some alveoli, (2) a variation in the mechanical properties of the surrounding opened alveoli, or (3) a possible modification in tidal volumes and functional residual capacities during O2 breathing.

Blood Gas Analysis↗
PubMed1982

[Transplantation of pediatric kidneys into adult patients (author's transl)].

Fourteen adult patients were transplanted with a single pediatric kidney and were followed for 26 days to 9 years. Donor ages ranged from 22 months to 10 years, recipient ages from 15 to 47 years. Ten transplants functioned for more than one year. Three kidneys were rejected after 26 days, 3 months and 18 months. Three patients died 2, 6 and 13 months after transplantation from aspergillosis, cytomegalovirus infection and salmonellosis. Eight kidney grafts are currently functioning 2 to 9 years after transplantation. Serum creatinin levels range between 0.9 and 1.1 mg/dl in 7 patients. One woman with chronic rejection has a serum creatinin level of 2.5 mg/dl. A single pediatric kidney is able to sustain a satisfactory renal function in an adult recipient.

Adult↗
PubMed1981

Transplantation of both kidneys of an anencephalic newborn to a 23-year-old patient.

Both kidneys of an anencephalic newborn were transplanted into a 23-year-old male patient. Hemodialysis was required for 3 weeks postoperatively. Both organs increased in size but did not reach the normal volume of an adult kidney. 3 years post-transplantation, the patient is doing well with a plasma creatinine level of 1.5 mg/dl. Technical problems are discussed.

Adult↗