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Biomedical subjects

M Verhaeghe

Publications and source records attributed to M Verhaeghe.

At least 19 recordsLinked to original sources
PubMed1990

Identification of essential amino acids in the active center of thyroidal NAD+ glycohydrolase.

1. Purified thyroidal NAD+ glycohydrolase has been subjected to the action of a number of group specific reagents in order to gain information concerning its mode of action. 2. Modification of histidyl residues with diethylpyrocarbonate strongly suppresses the NAD+ glycohydrolase activity. Inactivation with this reagent can be reversed to some extent by subsequent treatment with hydroxylamine. 3. NAD+ and ADP-ribose partially protect against inactivation with similar efficiencies. 4. The incomplete reactivation with hydroxylamine after diethylpyrocarbonate treatment and the selective inactivation by 2,4-pentanedione indicates that apart from one or more essential histidyl residue(s) also lysyl residues are important for activity. NAD+ and to a smaller extent ADP-ribose again protect against inactivation by 2,4-pentanedione. 5. The sensitivity of the enzyme towards N-ethyl-5-phenyl-isooxazolium-3'-sulfonate further points to the importance of carboxylate containing side chains. 6. The mechanistic implications of these results are discussed.

Amino Acids↗
PubMed1986

[Pregnancy after treated breast cancer. Results of a case-control study].

Sixty-eight cases of pregnancy after carcinoma of the breast were collected during a survey conducted by the Société Française de Gynécologie: 27 patients had one or several pregnancies interrupted at an early stage; 41 patients had at least one uninterrupted pregnancy. The fate of these patients was compared to that of 136 controls similar in all respects, except for the absence of post-cancer pregnancy. There was no significant difference in survival curves: the 10-year survival rate in our 68 patients was 71% (90% in those with N- cancer; 71% in those with N+ cancer, with no significant difference between cases and controls in each group). The patients whose pregnancies were interrupted had the same prognosis as those who delivered at term. The survival of 14 patients who conceived within 6 months of the breast cancer treatment was not significantly different from that of the corresponding controls. Pregnancy after breast cancer does not seem to alter the prognosis of the disease. In women with good prognosis cancer, the survival rate is excellent whatever the delay between cancer and pregnancy, and women should not be discouraged from having children; in women with poor prognosis cancer (N+), the outcome is not modified by pregnancy, and it remains lethal in about 50% of cases.

Adult↗
PubMed1986

[Pregnancy following surgery for cancer of the breast].

Twenty-tree cases of pregnancy subsequent to mastectomy for carcinoma of the breast were observed. This association accounts for 8% of cases of breast carcinoma in potentially fertile women under 40. The overall prognosis is good, with a crude survival of 89% at 5 years and 70% at 10 and 15 years, superior to the figures observed in a control group matched for age, stage and date of treatment. Nevertheless, after elimination of the "selection effect" (pregnancy is more likely to occur in patients with a prolonged survival and no evidence of disease), no evidence of a biological effect of pregnancy was found: the prognosis in cases in which the delay from cancer to pregnancy is short is not different from the prognosis of the matched group. However, the disease free interval was longer in the pregnancy group.

Adenocarcinoma↗
PubMed1982

[Surgery's place in the treatment of ovarian cancer].

Surgery must remain in first place as it allows for: --biopsy by direct access, --the assessment of the peritoneal and visceral extensions, --a cytological pre-operative study of the liquid of the peritoneal lavage which might lead the surgeon to suspect otherwise unnoticed extensions--a frozen section examination of the lumbar nodes or of the other apparently normal ovary. But surgery is, above all, indispensable in order to achieve "tumoral reduction", as large as possible by total hysterectomy with the ablation of both annexae as well as of the epiploon. Nevertheless the surgeon is often obliged to leave cancerous centers impossible to remove and he also fails to recognize the mini-centers grafted on the peritoneum and the viscera; he therefore has an imperative need of the complementary actions of polychemo--or radiation therapy in order to sterilise or neutralize these centers. A routine "second look" after chemotherapy must be done even if laparoscopy is negative; this makes it possible to judge whether treatment can be discontinued; it seems capable of significantly increasing the chances of treatment in the case of a limited recurrence of a slightly developed tumor; it can make possible secondary exeresis of certain originally inoperable forms. Combined treatment and secondary controls, in particular by means of a re-intervention appear to be a serious hope of improving the results thanks, above all, to the recent contribution of chemotherapy.

Female↗
PubMed1981

[Intrathoracic chemodectomas. A report on four observations (author's transl)].

Intrathoracic chemodectomas are extremely rare tumours, the number, published up to the present time being less than 50. We wish to report here four personal cases, all resected. The diagnosis was never made before surgery but solely by histopathology. The course was benign in two cases and malignant with slow progression in one case and malignant with rapid progression in the other. On the basis of these four cases, a general review is undertaken of this particular site on the basis of publications in the literature.

Adult↗
PubMed1979

[Invasive carcinoma of the uterine cervix associated with pregnancy (author's transl)].

In 4,396 invasive cervix carcinomas treated between 1934 and 1973, 52 occurred during pregnancy or within 3 months post partum. Stages I were more frequent among pregnant women (24%) than without pregnancy (8%) and stages II were as frequent (50%). Stages I and II were more frequent among pregnant women treated during 1963-1973 than 1934-1962. The 3 years' survival rate, all stages combined, for pregnant women (42%) was lower than for matched control non-pregnant women (62%). This difference was significant at P = 0.05, but at 5 and 10 years, the difference was not significant for patients treated between 1963-1973. At an equal stage, survival rate seemed lower for stages IIb and III (P = 0.02 for these two stages combined.) The lymph node involvement was not more frequent; the decrease of global survival rate could be associated to some factors and especially incomplete therapy and an under-estimation of the tumor extension because of the pregnancy. Our results are compared to the data literature and therapeutic schedules are discussed.

Abortion, Therapeutic↗
PubMed1979

[Carcinoma in situ of the uterine cervix. Experience of the Centre Oscar Labret of Lille (author's transl)].

Forty cases of carcinoma in situ of the cervix were seen in the "Center Oscar Labret" of Lille between 1953 and 1978. The best treatment appears to be only simple total hysterectomy. Twenty patients underwent such an operation. seven In the course attended of follow-up, among 36 patients who regularly the out-patient clinic, there was one case of persistent progression and one early vaginal recurrence of the carcinoma in situ.

Adult↗