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Biomedical subjects

M Velasco

Publications and source records attributed to M Velasco.

At least 235 records · Page 13Linked to original sources
PubMed1981

Effect of minoxidil on sympathetic nervous activity in clonidine-treated hypertensive patients.

The effects of clonidine and minoxidil on sympathetic nervous activity has been studied in 10 patients with accelerated or resistant hypertension. Clonidine 150 to 900 micrograms/day caused a significant decrease in blood pressure of 18.6 mm Hg, of heart rate 16.4 beats/min, of plasma renin activity 1.13ng/ml h, and of urinary noradrenaline excretion 11.55 micrograms/day, and a significant lengthening of the pre-injection period of 12.4 ms. Minoxidil 5 to 22.5 micrograms/day caused a further significant decrease in blood pressure of 24.2 mm Hg, and significant increases in heart rate 8.2 beats/min, plasma renin activity 1.68 ng/ml h and of urinary noradrenaline excretion 5.0 micrograms/day, and a significant shortening of the pre-ejection period of 20.6 ms. Neither clonidine nor minoxidil altered plasma dopamine beta-hydroxylase activity or the cardiovascular responses to treadmill exercise. It is concluded that clonidine is a useful alternative agent to block a minoxidil-induced increase in sympathetic nervous activity.

Adult↗
PubMed1981

Systemic and cardiac hemodynamic interactions between clonidine and minoxidil.

We examined the hemodynamic interaction between clonidine, a centrally acting antiadrenergic drug, and minoxidil, a potent antihypertensive vasodilator in 10 inpatients with refractory or accelerated hypertension or both. Clonidine in oral doses of 150 to 900 micrograms/day decreased average mean blood pressure 18.6 mm Hg (p less than 0.01), average heart rate 16.4 bpm (p less than 0.01), limb blood flow 1.63 ml/100 gm . min (p less than 0.05), and plasma renin activity 1.13 ng/ml . hr (p less than 0.025). It also increased the pre-ejection period index 12.4 msec (p less than 0.001), but did not alter the cardiac or total peripheral resistance indices. The addition of minoxidil in oral doses of 5 to 22.5 mg/day further decreased average mean blood pressure 24.2 mm Hg (p less than 0.01), preejection period index 20.6 msec (p less than 0.01), limb vascular resistance 13.2 mm Hg/min . 100 gm/ml (p less than 0.05), and total peripheral resistance 13.3 mm Hg/min . m2/l (p less than 0.01), pre-ejection period index 20.6 msec (p less than 0.01), limb vascular resistance 13.2 mm Hg/min . 100 gm/ml (p less than 0.05), and total peripheral resistance 13.3 mm Hg/min . m2/l concluded that clonidine can be used as an alternative to beta-adrenergic blockers to counteract the increased sympathetic nervous activity minoxidil induces.

Adult↗
PubMed1981

Mathematical-statistical evaluation of hypophyseal and ovarian response to Gn-RH and to D-Leu6-des Gly10-LH-RH-EA stimulation in patients with amenorrhea.

In a group of 30 women with secondary amenorrhea the administration of D-Leu6-des Gly10-LH-RH-EA Analogue 25 mcg i.m. leads to a more intense and prolonged gonadotrophin response than synthetic Gn-RH 100 mcg i.v. The ovarian response to Gn-Rh is remarkable and lasts for approximately 24 hours; the stimulation with Analogue leads to a response which is slightly more intense than the one induced by Gn-RH, but probably of longer duration.

Adolescent↗
PubMed1981

Bromoergocriptin therapy in eumenorrhoic patients presenting galactorrhea.

Eleven eumenorrhoic patients presenting galactorrhea were subjected to a three-month Bromoergocryptin therapy (2.5 mg/os/die). Prolactin Circadian Rhythm, performed on all patients, showed four hyper and seven normoprolactinemic cases. The mammary condition was studied, before and after treatment, through clinical examination, mammary cytology and thermography. Hyperprolactinemic patients responded positively to the therapy, showing subjective, clinical and thermographic improvement. Conversely, normoprolactinemic patients, though showing a noteworthy improvement of symptomatology and galactorrhea, did not respond equally well from the objective and thermographic points of view.

Adult↗
PubMed1981

Proposal of diagnostic approach in mammary pathology.

The Authors, on the basis of the literature and their own experience, propose a diagnostic schedule for detection of breast disease based on integrated thermography, diaphanoscopy, echography and mammography.

Biopsy, Needle↗
PubMed1980

Alumina cream-induced focal motor epilepsy in cats. IV. Thickness and cellularity of layers in the perilesional motor cortex.

Thickness and cellularity of motor cortical layers adjacent to epileptogenic lesions produced by administration of alumina cream (AC) were measured in the brains of 18 cats that were at latent, convulsive, and remissive stages of an experimental model of epilepsy. Sham-operated animals were used as controls. Brains were fixed by perfusion and embedded in paraffin. Sections of motor cortex adjacent to the AC deposit were obtained at constant thickness to measure thickness and cellularity in each cortical layer. A statistically significant reduction in thickness and cellularity was detected in layers 2, 4, and 6, whereas reduction in these aspects was not significant in layers 3 and 5 in the initial stages of the model (latent and convulsive). It is suggested that AC may exert a cytotoxic effect on inhibitory neurons located at layers 2 and 4, to determine an imbalance of intracortical excitability.

Aluminum Hydroxide↗
PubMed1980

Specific and non-specific multiple unit activities during pentylenetetrazol seizures. I. Animals with 'encéphale isolé'.

The present report describes the sequence of activation and deactivation of multiple unit activities (MUA) in the brain stem reticular formation and pyramidal tract, in relation to the clinical seizure and electroencephalographic and electromyographic tonic-clonic discharges induced by pentylenetetrazol (PTZ), in cats immobilized by high spinal transection ('encéphale isolé'). Threshold doses of PTZ (20 mg/kg i.v.) produced the following events: (1) Significant increase in mesencephalic and pontine MUA, anticipating 2 (+/- 1) sec the clinical and electromyographic seizures and 5 (+/- 2) sec the onset of EEG and pyramidal tract tonic-clonic discharges. (2) A further increase in mesencephalic and pontine reticular MUA and electromyogram MUA at the onset of EEG and pyramidal tract tonic-clonic discharges. (3) Significant decrease of EEG spike activity and pyramidal tract MUA to levels below the control period 16 (+/- 8) sec later, while mesencephalic and pontine MUA and electromyogram remained very high. Results suggest that (i) PTZ-induced seizures start in the brain stem reticular formation and propagate to muscles by at least two different pathways: a pyramidal and an extrapyramidal pathway; (ii) that inhibition of seizure activity may start at the cortical level.

Action Potentials↗