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Biomedical subjects

M Vaquero

Publications and source records attributed to M Vaquero.

At least 55 records · Page 3Linked to original sources
PubMed1997

Low-grade, malt-type, primary B-cell lymphoma of the conjunctiva.

Although primary ocular lymphomas may be found in the conjunctiva, eye lids and lacrimal glands, the majority nevertheless occur in the orbit. Only a few cases of primary conjunctival lymphoma have been described in the literature. A 68-year-old man presented with a painless swelling of the epibulbar conjunctiva of the right eye. A diffuse lymphoid infiltrate consisting of small-sized lymphoid cells with the morphology and distribution characteristics of mucosa-associated lymphoid tissue was observed. Immunohistological study demonstrated the B lymphocyte lineage of tumor cells and Bcl-1 and bcl-2 rearrangements were negative. After clinical staging including thoracic, abdominal, brain and orbital CT scans, fiberoptic gastroscopy and bone marrow biopsy, no other foci of this lymphoma were found. Radiation therapy was given and the patient currently remains free of lymphoma 30 months after diagnosis.

Aged↗
PubMed1997

The clinical spectrum of remitting seronegative symmetrical synovitis with pitting edema. The Catalán Group for the Study of RS3PE.

OBJECTIVE: To describe the clinical and laboratory features and outcome of patients with remitting seronegative symmetrical synovitis with pitting edema (RS3PE). METHODS: A retrospective multicenter study of patients with RS3PE fulfilling the following criteria: (1) bilateral pitting edema of both hands, (2) sudden onset of polyarthritis, (3) age > 50 years, (4) seronegative for rheumatoid factor (RF). RESULTS: 27 patients with RS3PE were included, mean age 71.7 years (58-92), 18 men (66.6%) and 9 women (33.3%). Relevant history was noted in 2 patients with polymyalgia rheumatica. Main clinical features were polyarthritis and edema of both hands. Polyarthritis involved metacarpophalangeal joints in 22 patients (81.5%), proximal interphalangeal joints in 19 (70.4%), wrists in 15 (55.5%), shoulders in 13 (48%), elbows in 3 (11.1%), knees in 9 (33.3%), and ankles in 7 (25.9%). All patients were RF negative. Antinuclear antibodies were positive at low titer in 8 patients. Erosions were present in one patient. Two patients developed T lymphoma and one myelodysplastic syndrome. CONCLUSION: RS3PE is a heterogeneous syndrome the clinical history, presence of erosions, and evolution to hematological diseases in our patients suggest that RS3PE may not be a distinct clinical entity.

Adrenal Cortex Hormones↗
PubMed1997

[Clinical interest of a new simple system for isolating Mycobacterium tuberculosis].

BACKGROUND: A new system, Mycobacteria Growth Indicator Tube (MGIT), was used for the recovery of M. tuberculosis from clinical specimens, which was compared with conventional methods of microbiological methods. The MGIT system consists of tubes containing liquid medium and a fluorescent oxygen consumption sensor to detect bacterial growth. METHODS: A total of 197 clinical specimens from 162 patients with clinical suspicion of tuberculosis were processed in parallel and seeded in the new system, the radiometric system BACTEC and Löwenstein. RESULTS: The validity criteria for the new system were: sensitivity, 95.4%; specificity, 100%; negative predictive value, 89.3%, and positive predictive value, 100%. The greatest clinical agreement occurred with MGIT and BACTEC. The mean time up to diagnosis of M. tuberculosis recovered from patients was 11 days (range: 7-13 days). No significant differences were found regarding contamination of respiratory samples in the three systems. CONCLUSION: Given the simplicity of utilization of the new system-which does not require radioactive compounds- and the results, the MGIT system appears as an easy-to-use new method, which yields results in a short time, with a good sensitivity in detecting Mycobacterium tuberculosis from clinical specimens from suspected patients with tuberculosis.

Bacteriological Techniques↗
PubMed1997

Comparative evaluation of the mycobacteria growth indicator tube with the BACTEC 460 TB system and Löwenstein-Jensen medium for isolation of mycobacteria from clinical specimens.

SETTING: The utilization of new simples and rapid methods of diagnosis is currently of great interest for tuberculosis control. OBJECTIVE: The Mycobacteria Growth Indicator Tube (MGIT) was evaluated and compared with the BACTEC 460 TB system and Löwenstein-Jensen (LJ) medium for isolation capacity and detection time of mycobacteria. DESIGN: In total 337 specimens from various body sites of 276 patients were tested for the presence of mycobacteria. Specimens were decontaminated using the standard Na OH-NALC method, then processed in MGIT broth, in BACTEC vial, and on LJ medium for comparative study. Ziehl Neelsen staining was used as a reference. RESULTS: MGIT had 95.4% sensitivity, 100% specificity, 100% positive predictive value, and 89.3% negative predictive value. The clinical concordance between MGIT and LJ medium was 0.87 and between MGIT and BACTEC, 0.96. The mean time to detection for Mycobacterium tuberculosis was 11 days (range 7-31 days) with MGIT. For M. avium and other atypical mycobacteria, the mean time to detection were 3 and 8 days, respectively. CONCLUSION: The Mycobacteria Growth Indicator Tube appears to be a rapid, easy-to-use system with a high accuracy for detecting mycobacteria directly from clinical specimens.

Bacteriological Techniques↗
PubMed1996

[Disseminated histoplasmosis and AIDS. Report of 4 cases].

Disseminated histoplasmosis is frequent in patients with HIV infection from endemic zones of Africa and South America. It is infrequent in Europe. Four cases diagnosed as disseminated histoplasmosis among a total of 1,100 AIDS cases reported from 1984 to 1994 were reviewed. Four males with a mean age of 40 years were reviewed. Two were from Argentina, one from Gambia with HIV-2 infection and the remaining case was a Spanish man who had made numerous travels to endemic zones. Prolonged fever without an apparent focci in the previous weeks was the clinical manifestation at the onset in all the cases. Diagnosis was performed by bone marrow aspirate (1 case), histologic study of the cutaneous lesions (1 case) and on autopsy with the diagnosis not being suspected during life (2 cases). Tracheal ulcers and hyperferritinemia are the main peculiarities of the two cases presented. Antifungal treatment with amphotericin B and secondary prophylaxis with itraconazole were effective in one of the cases. It is important to take histoplasmosis into account in the differential diagnosis of prolonged fever in patients with HIV infection from endemic zones.

Acquired Immunodeficiency Syndrome↗
PubMed1996

[Lymphoma of the marginal zone of the spleen. A case study].

Lymphomas of the marginal spleen zone are an entity recently considered as separate by the International Lymphoma Study Group. There are B-cell non Hodgkin's lymphomas (NHL) of low grade malignancy with a characteristic phenotype that allows to differentiate from mantle lymphomas and other B-cell lymphoproliferative syndromes. The case of a 69-year-old female patient admitted for abdominal pain due to large splenomegaly is reported. Pancytopenia and the presence of atypical large-sized lymphocytes with extensive cytoplasm and a rounded nucleus with indentations, reticulated appearing chromatin and one or several nucleoli were of note in the hemogram. Microscopic examination of the bone marrow demonstrated moderate-degree lymphocytary infiltration with grade I reticulin fibrosis. Laparotomy with splenectomy was performed. White pulp invasion with multifocal infiltration of the red pulp by lymphocytes of the same characteristics as those observed in the peripheral blood and bone marrow were observed on microscopic bone marrow examination. Immunophenotypic study of these lymphocytes was positive for CD19, CD20 and CD22 while being negative for CD5, CD10, CD23, CD25, CD11c and FMC7, the phenotype belonging to the lymphocytes of marginal spleen zone. Following splenectomy the patient recovered hemoperipheral counts and did not undergo additional treatment. The patient died due to septic shock of respiratory origin 4 months later. The clinical, morphologic and immunophenotypic features of marginal spleen zone lymphomas are reported with emphasis on the differences with other B-cell non Hodgkin's lymphomas of low malignancy.

Aged↗
PubMed1996

Visual function with monofocal versus multifocal IOLs.

PURPOSE: To assess visual outcome in four groups: one multifocal intraocular lens (IOL), one monofocal IOL, and two phakic, one older and one younger. SETTING: Department of Ophthalmology, National Health Service, Puerta de Hierro University Clinic, Madrid, Spain. METHODS: This prospective study comprised 70 aphakic eyes, 42 with a multifocal and 28 with a monofocal IOL, and 42 phakic eyes, 21 older than 60 years and 21 younger than 60 years. The phakic groups served as a double control. Main outcome measures were corrected and uncorrected distance and near visual acuities, contrast and glare sensitivity, and clinical and subjective complications. RESULTS: There were no significant differences between the monofocal and multifocal IOL groups in uncorrected or corrected distance visual acuity. Near visual acuity in the multifocal group, with and without distance correction, was significantly better than in the monofocal group. Near vision with addition was similar between the two IOL groups. There were no significant differences between the monofocal and multifocal IOL groups in contrast sensitivity at the 96 and 50% thresholds. Between-group differences of less than one Regan line were found at the 25 and 11% thresholds. The phakic groups had better contrast sensitivity. The older phakic group's results were closer to those of the IOL groups. There were no significant complications. CONCLUSION: Distance acuity and contrast sensitivity were similar in the monofocal and multifocal IOL groups; however, the multifocal group had significantly better near acuity. The younger phakic group had significantly better contrast sensitivity than the other groups.

Adult↗
PubMed1995

[Pseudotumorous hyperplasia of the caudate lobe of the liver in a patient with Alagille syndrome].

The Alagille's syndrome consists in hypoplasia of the intrahepatic biliary ducts associated to congenital abnormalities of different organs. It is usually diagnosed in infancy due to cholestasis with good prognosis. The case of a 31-year old women who presented prominent chin, micrognathia, flattening of the nasal bone, infundibular stenosis of the pulmonary artery and cholestasis is reported. Ultrasonography demonstrated a lesion in the space of the hepatic caudate lobe with punction showing sinusoidal dilatation and infiltration of some portal spaces by lymphocytes, eosinophils and neutrophils. Samples of liver tissue obtained during laparotomy showed an absence of intrahepatic biliary ducts in the right and left lobes and preservation of those of the caudate lobe, which was also increased in size with a pseudotumoral appearance. The patients was asymptomatic with slight anicteric cholestasis at 16 months of diagnosis. The rarity of these forms of Alagille's syndrome with areas free of hypoplasia of the intrahepatic biliary ducts are of note.

Adult↗
PubMed1995

[Granulocytic sarcoma: a study of 5 cases].

Granulocytic sarcoma (GS) is a solid tumor of extramedullary localization constituted by immature precursors from the granulocytic series. GS may be diagnosed in different malignant blood diseases involving the granulocytic series, acute non lymphoblastic leukemia (ANLL) being the most frequent, followed by myelodysplastic syndromes (MDS) and chronic myeloproliferative syndromes, specially chronic myeloid leukemia (CML) in blastic crisis. Although the diagnosis of GS is suspected with conventional cytologic and anatomopathologic studies, histochemical staining and immunohistochemical techniques are often required for definitive diagnosis. Five cases (4 males, 1 female; age range 22-77 years) diagnosed with GS in one center over a period of nine years (1984-1993) are described. The GS were located in the lymph nodes, the jaw, paravertebral region, gallbladder and retroperitoneum, respectively. Two patients had refractory anemia with excess of blasts (RAEB). Three patients had ANLL; in one GS constituted the form of relapse, in another GS presented at the time of diagnosis and in the remaining patient GS preceded the diagnosis of ANLL. All the patients died from 2 to 8 months after diagnosis of GS with no response to treatment being observed. Immunohistochemical study of the tumor was performed in 4 patients, being positive for lysozyme and the monocytic MAC-387 monoclonal antibody. Immunocytochemical study of the tumor blasts was carried out with positivity for CD15 being observed. Although uncommon, GS should be suspected in patients with ANLL or MDS with tumors of any localization and at any time during its evolution. Immunocytochemical and immunohistochemical studies are of great value to differentiate GS from other tumors, particularly anaplastic non Hodgkin's lymphomas.

Adult↗
PubMed1995

[Primary extralymphatic non-Hodgkin's lymphomas: the response to treatment and prognostic factors in 73 patients].

BACKGROUND: The aim of the present study was to determine the prognostic factors for treatment response, relapse-free survival (RFS) and overall survival (OS) in a series of 73 patients with primary extranodal lymphomas (PEL). METHODS: All the patients diagnosed with PEL in one center from January 1984 to December 1993 were studied. The Working Formulation was used for histologic classification and the stage was determined according to the Ann Arbor classification modified by Mushoff. Age, sex, localization of the lymphoma, the presence of B symptoms, the existence of bulky disease, human immunodeficiency virus (HIV) infection, the main hematological and biochemical parameters, the histologic grade of malignancy, the immunologic phenotype and stage were reported. Univariate and multivariate analyses of prognostic factors for complete response (CR), RFS and OS were carried out. RESULTS: The most frequent localization of PEL was the gastrointestinal tract (43 cases). Fourteen cases had HIV infection. CR was obtained in 37 out of the 55 patients (67%) of whom 8 (21%) had relapsed. Serum LDH level was the main prognostic factor for CR attainment (p = 0.01). The variables which negatively affected RFS were the presence of HIV infection (p = 0.02), advanced age (p = 0.018) and the existence of B symptoms (p = 0.02). OS was shorter in patients with high LDH levels (p = 0.004) and more aggressive histologic subtype (p = 0.0002). CONCLUSIONS: The prognostic factors observed in the patients with primary extranodal lymphomas are the same as those found in nodal non Hodgkin's lymphomas. The stage is not a factor of bad prognosis if chemotherapy is included in the treatment.

Adult↗
PubMed1994

Uterine papillary serous adenocarcinoma. A 10-case study of p53 and c-erbB-2 expression and DNA content.

BACKGROUND: Uterine papillary serous adenocarcinoma (UPSA) is a highly aggressive neoplasm with a great tendency for dissemination. p53 and c-erbB-2 immunoreactivity and DNA ploidy are considered to be indicators of prognosis for endometrial carcinomas. METHODS: Ten cases of patients with UPSA are reported. An attempt to relate pathologic findings with immunohistochemical stains for p53- and c-erbB-2-associated proteins, ploidy, and survival was made. RESULTS: Three patients were classified as having Stage I; three, Stage II; two, Stage III; and two, Stage IV. Myometrial invasion was present with nine tumors and involved over 50% of the myometrial thickness in five. Uterine lymph vessel invasion was detected in seven cases. Peritoneal spread occurred in six patients. Overexpression of p53 was observed in six tumors, immunoreactivity for c-erbB-2 in four, and aneuploidy in seven. However, only peritoneal spread correlated significantly with survival (P < 0.005). CONCLUSIONS: UPSA is a tumor with a high metastatic potential that exhibits immunoreactivity for p53 and c-erbB-2 and aneuploidy more often than that reported for conventional endometrioid adenocarcinomas.

Adult↗