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Biomedical subjects

M Vanden Bossche

Publications and source records attributed to M Vanden Bossche.

11 recordsLinked to original sources
PubMed1999

[Cancer of the prostate: what treatment for what stage?].

The treatment of locally advanced prostatic cancer is the most controversial subject in urological oncology. Localized disease is best treated by radical prostatectomy or radiotherapy. Metastatic cancer is treated by surgical or medical castration. Second line therapeutics will be overviewed. Each treatment decision is based upon the pathological stage and differentiation of the tumour, the life expectancy and comorbidity of the patient.

Antineoplastic Agents, Hormonal↗
PubMed1999

[Infectious pathologies of the prostate].

Prostatitis represents an heterogenic disease: we describe acute bacterial prostatitis, chronic bacterial prostatitis, chronic abacterial prostatitis and prostatodynia. Acute bacterial prostatitis is treated easily as an acute infection since chronic prostatitis needs a long and difficult treatment. In both cases, fluoroquinolones are the antibiotics of choice. Prostatodynia is treated by alpha-blockers. Granulomatous prostatitis is evocated in terms of differential diagnosis.

Acute Disease↗
PubMed1993

Hyperthermia and thermotherapy of benign prostatic hyperplasia: a critical review.

The indications, risks and benefits of surgical treatment of benign prostatic hyperplasia (BPH) have recently been scrutinized, and interest in the development of less invasive alternative nonsurgical approaches has emerged. Among the nonsurgical alternatives, thermal treatments have been clinically introduced for a few years but are still under evaluation. Microwaves and radiofrequency waves are generated by various devices applied by the transrectal or transurethral approach, with different treatment and temperature schedules. Results achieved with the various devices did not show large significant differences. Improvement is mainly observed by a decrease in irritative symptoms rather than by modifications of obstructive parameters. The placebo effect must not be underestimated in all these new alternative methods. Fifty percent of patients in retention and unfit for anesthesia voided satisfactorily after thermal treatment. Pathological studies of operative specimens after transurethral thermotherapy showed coagulative necrosis with destruction of smooth muscle and glandular components. The destruction of alpha-receptors or sensory nerves in the prostate stroma is a possible explanation for the reduction of irritative symptoms. No significant histological lesions were found however after transrectal hyperthermia. Various factors such as differences in tissue thermosensitivity, tissular architecture and thermoregulation related to variation in the prostate blood supply may all play a part in the final heating effect and determine the clinical response for a given patient. Better understanding of these various factors may improve patient selection. Although thermal treatment of BPH cannot be seen as a substitution for surgery, it may represent an alternative option in selected patients essentially to alleviate irritative symptoms.(ABSTRACT TRUNCATED AT 250 WORDS)

Electromagnetic Phenomena↗
PubMed1991

[The effects of mepartricin on the symptomatology of prostatic hypertrophy--double-blind controlled trial].

Seventy one patients were treated with mepartricin or placebo in three urological centres for a mean duration of 102 days (extremes: 60 and 142 days). An analysis of the results was carried out for 34 patients in the placebo group and 36 patients in the mepartricin group. The results indicate a significant improvement in both the placebo group and the mepartricin group. The irritative and obstructive symptoms are improved in the active treatment group with a response rate of the order of 70%, compared to approx. 45% in the placebo group. An improvement of the values on the flow meter, though not statistically significant, is observed following treatment with mepartricin, compared to the placebo group. There were no significant differences in the evolution of the prostate gland volume, determined by ultrasound in the placebo group and the active treatment group. Side-effects were minor and only one patient reported epigastric pain.

Aged↗
PubMed1990

Transrectal ultrasound in the diagnosis and staging of prostatic carcinoma.

In this retrospective study we try to evaluate the benefit of transrectal ultrasonography of the prostate in the diagnostic, the screening and the preoperative staging of prostatic carcinoma. Five hundred and sixty-six patients with histologically proved prostatic carcinoma were evaluated. For the diagnosis, our specificity was 80%. The specificity of preoperative staging was 85% concerning the extraprostatic extension of the tumor. The screening seems to be of poor interest.

Humans↗
PubMed1990

Shock wave monotherapy of staghorn calculi.

From June 1987 to October 1988, 52 staghorn calculi were treated without anesthesia by shock wave lithotripsy with the second-generation lithotriptor, Lithostar Siemens. 36 calculi were evaluated. Multiple sessions (n = 1-6) were necessary according to the size of the stone. The mean hospital stay for complete treatment was 7 days. Double-J stenting was used in 45% of the patients with calculi of less than 40 mm and in 81% of the patients with calculi of greater than 40 mm. After 3 months, 50% of the patients with calculi of less than 40 mm were free of stones, as were 43% of the patients with calculi greater than 40 mm. After 9 months, the stone-free rate rose to 75%. At 3 months, the success rate (stone free or residual fragments of less than 4 mm) is 87.5% and rose to 92% at 9 months. Two severe complications were observed: one patient with acute infected hydronephrosis with sepsis and one with perirenal hematoma. Shock wave lithotripsy monotherapy of staghorn calculi is possible in multiple treatment sessions. Double-J stenting is mandatory in most of the cases but, even in this condition, anesthesia is not necessary.

Humans↗
PubMed1990

Shockwave treatment of ureteric stones in situ with second-generation lithotriptor.

During a 17-month period we treated in situ 334 patients with ureteric stones with a second-generation electromagnetic lithotriptor. Anxiety and discomfort were relieved with diazepam and pethidine chloride only. Ureteral stenting was used in 8.1% of upper, 36.4% of mid- and 5.7% of lower ureteric stones. The retreatment rate was 15%, but no patient had more than 3 sessions. The success rate of the treatment at 3 months was 88% for upper, 65% for mid- and 83% for lower ureteric stones. Open surgery had to be performed in 5 cases and ureteroscopies in 6 cases.

Diazepam↗
PubMed1989

[Reliability of endorectal echography of the prostate in the screening and staging of prostatic cancer].

1433 transrectal ultrasonographies were performed for prostatic disease. In 453 cases, histopathologic correlation was obtained and compared to digital rectal examination and transrectal ultrasonography done after the clinical examination. The sensitivity of digital rectal examination was 91% and the specificity was 85%. The sensitivity and the specificity of ultrasonography were respectively 95 and 81%. 4 prostatic cancers, not suspected by digital rectal examination, were diagnosed by ultrasound (0,9%). The total number of subclinical cancer was 9 (2%). Interest of ultrasound compared to digital rectal examination concerns less than 1% of the total number of controlled patients. The staging of local extension of prostatic cancer is better by ultrasound than by the digital rectal examination. On 9 cases of clinical unsuspected extracapsular invasion, 6 were diagnosed by ultrasound.

Humans↗