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Biomedical subjects

M Vall

Publications and source records attributed to M Vall.

5 recordsLinked to original sources
PubMed1989

Prevalence of antibodies to hepatitis C virus in Spanish patients with hepatocellular carcinoma and hepatic cirrhosis.

The prevalence of antibodies against hepatitis C virus (HCV) was investigated in 96 patients with hepatocellular carcinoma, 106 patients with liver cirrhosis without evidence of cancer, and 177 controls without liver disease. 75% of patients with hepatocellular carcinoma had HCV antibodies (anti-HCV), a significantly higher proportion than that observed in patients with cirrhosis (55.6%), or controls (7.3%). The prevalence of anti-HCV was significantly higher in patients with alcoholic cirrhosis and hepatocellular carcinoma (76%) than in patients with alcoholic cirrhosis alone (38.7%) whereas in patients with cryptogenic cirrhosis there was no significant difference between those with and without primary liver cell cancer (81.4% and 77.5%, respectively). These results indicate that HCV infection may have a role in the pathogenesis of hepatocellular carcinoma, even in patients with chronic liver disease apparently related to other agents such as alcohol, and that this recently identified hepatitis virus may be found in a large proportion of patients with cryptogenic cirrhosis.

Aged↗
PubMed1986

[Bladder hemangiomas].

Three further cases of bladder hemangioma are reported. Two were adults, with a previous history of hematuria, diagnosed by endoscopy and treated by external radiotherapy. The other case was an 8 year old child, diagnosed by radiologic, CT scan and endoscopic examinations and confirmed by histology, for whom an attitude of expectant prudence was adopted.

Adult↗
PubMed1982

Comparative changes with age of the fasting response in circulating ketone bodies, glucose and insulin and oral glucose tolerance test in the rat.

1. Body weight loss in 48 hr fasted rats decreased with age. 2. Blood glucose and plasma RIA-insulin levels correlated negatively and positively respectively with body weight in fed rats. Fasting produced a greater fall in blood glucose and a smaller decrease in RIA-insulin in young than in old rats. 3. Blood ketone bodies correlated negatively with body weight after 48 hr fasting. 4. In oral glucose tolerance tests, blood glucose rose more in adult and old rats than in prepuberals when both fed and fasted. RIA-insulin levels rose more in prepuberals than in older rats when fed but not when fasted. 5. Changes in body composition and reduced insulin sensitivity with age are discussed.

Aging↗
PubMed1980

Changes in plasma glucose, insulin and glucagon levels, glucose tolerance tests and insulin sensitivity with age in the rat.

Glucose and insulin relationships with aging were studied in fed rats. Levels of basal circulating glucose did not change while those of RIA-insulin increased and RIA-glucagon decreased lineary with animal weight. The oral glucose tolerance test revealed a greater increase in blood glucoe in adult and old rats than in prepuberals, while the rise in plasma insulin was faster and greater in the oldest group. After intravenous glucose load, plasma insulin increase was greater in adult than in prepuberal and old rats, and in the latter grup values remained elevated for a longer period. The hypoglycemic response to i.v. insulin was greatest in the prepuberals with no difference between adult and old rats. In prepuberals, the augmented insulin sensitivity was counteracted by retarded insulinotropic glucose action and an enhanced basal glucagon level, while in the old animals normoglycemia was maintained due to an augmented secretory response of B cells, counteracted by reduced sensitivity to endogenous insulin.

Aging↗