Biomedical subjects
M Valentin
Publications and source records attributed to M Valentin.
Modification of human serum albumin binding of methotrexate by folinic acid and certain drugs used in cancer chemotherapy.
The binding of methotrexate (MTX) and citrovorum factor (CF) to human serum albumin (HSA) was investigated. The affinity constant for MTX was 820 M-1, with 2 binding sites, and for CF 2340 M-1, with 1.5 binding sites. MTX and CF, which are used together in high dose therapy, compete for HSA binding. Competition for HSA binding between MTX and adriamycin, bleomycin and cyclophosphamide, drugs often used in association with MTX in cancer chemotherapy, was also demonstrated. The clinical importance of such competition depends on the drug/protein concentration ratio which is extremely variable.
[Accumulation 125I-fibrinogen test in diagnosis of venous thrombosis of limbs. Comparison with rtg phlebography (author's transl)].
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[The precursors of ergonomics].
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[Post-traumatic stiffness and ankylosis of the elbow. History].
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[Stiff-man syndrome].
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The unheard voices of women: spiritual interventions in maternal-child health.
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Medical determination (and preservation) of decision-making capacity.
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Alterations in ecdysone content during the post-embryonic development of Chironomus thummi: correlations with chromosomal puffing.
The ecdysone titer of larvae and pupae of Chironomus thummi was determined by radioimmune assay (RIA) and revealed a concentration of about 150 ng/g fresh weigth in late third instar larvae and a peak of more than 450 ng/g fresh weight just preceding pupation. The ecdysone titer curve shows a high degree of correlation with previously observed puffing activity at the ecdysone sensitive chromosomal site IIIdl. Further, beta-ecdysone is the only endogenous ecdysone detected by high pressure liquid chromatography during larval-pupal development. It was also observed that developmentally arrested Chironomus contain less ecdysone than "normal" larvae.
[Professor Roger Rullière (1926-1998)].
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[Dean Jean-Pierre Kerneis (1918-1999)].
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[3 forgotten precursors of Industrial Medicine: Antoine Portal (1742-1832), Amédée Lefèvre (1798-1869), and Maximilien de Beauharnais, Duke of Leuchtemberg (1817-1852)].
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