Biomedical subjects

M V Squier

Publications and source records attributed to M V Squier.

39 records · Page 3Linked to original sources

PubMed1979

Hepatotoxicity in the treatment of acute lymphoblastic leukaemia.

Serial liver function tests and percutaneous liver biopsies were performed on 21 children receiving treatment for acute lymphoblastic leukaemia (ALL). The patients received continuing chemotherapy either with daily 6-mercaptopurine and weekly methotrexate or with five-day pulses of these drugs every three weeks. Liver function tests were transiently abnormal in the majority of children, but the abnormalities bore no relationship to the histology of the liver biopsy. Mild inflammatory and fatty changes were commonly seen, and early portal fibrosis was found in three out of 16 patients biopsied at between 108-130 weeks on treatment. There was no correlation between treatment regime and results of biopsy. Three patients showed possible progression of abnormalities on repeat biopsy. The risk of development of portal fibrosis appears low after 2-3 years of continuing chemotherapy, but examination of liver histology may be indicated if more prolonged therapy is contemplated.

Adolescent↗

PubMedDate not supplied

Immunocytochemical characterization of the macrophage and lymphocyte infiltrate in the brain in six cases of human encephalitis of varied aetiology.

Monoclonal antibodies that react with various macrophage and lymphocyte sub-populations have been applied to acetone-fixed cryostat sections of brains from six cases of human meningo-encephalitis (two cases of subacute sclerosing panencephalitis, two cases of allergic encephalitis, one case of suspected entero-virus meningo-encephalitis and one case of meningo-encephalitis of undetermined origin). The patterns of inflammatory cell response that these antibodies reveal is described and discussed in comparison with published descriptions of the corresponding cell types found in the brain in Japanese encephalitis, herpes simplex encephalitis and multiple sclerosis. In general, in the acute phases of inflammatory central nervous system diseases, T lymphocytes and macrophages predominate in the parenchyma, while the early phases of a B cell response take place in perivascular spaces.

Adolescent↗

PubMedDate not supplied

Isolated capillary proliferation in Leigh's syndrome.

An infant with hypotonia and recurrent apneic spells died with a diagnosis of pyruvate dehydrogenase deficiency and showed typical pathological changes of Leigh's syndrome at postmortem. Despite the prominence of symptoms suggesting dysfunction of brainstem respiratory centers during life, lesions were not found in the upper medulla. However, quantitative morphometric analysis demonstrated abnormal capillary hyperplasia in the region including and between the nucleus ambiguus and nucleus tractus solitarius. There was an average area of 8.0 +/- 2.5 x 10(6) mm2 occupied by capillaries per 0.75 mm2 field in the patient's brainstem, compared with 4.6 +/- 1.6 x 10(6) mm2 and 5.5 +/- 1.4 x 10(6) mm2 in two age-matched controls (p < 0.01). We speculate that capillary hyperplasia is a pathological marker of chronically impaired oxidative metabolism in the central nervous system in metabolic disease.

Brain↗