Biomedical subjects
Publications and source records attributed to M V Severov.
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Hypersensitivity of a delayed type to leukocyte hepatitis virus (LHV) was established in patients with virus hepatitis. The results of the skin tests with the LHV antigen were positive in 15 out of 20 patients with active chronic hepatitis, in 17 out of 20 convalescents and in 3 out of 20 patients in the acute stage of virus hepatitis, and negative in 4 normal subjects and in 12 out of 14 patients with chronic hepatitis in the stage of stabilization. The results of the skin tests with the antigen of donor leukocytes were negative in 130 patients with hepatitis and normal subjects. In the leukocyte migration inhibition test, 1/4 of the patients with chronic hepatitis were found to be sensitized to the LHV antigen, in the absence of sensitization by this test to the HB antigen and the antigen in the plasma of hepatitis patient.
9 cases (males) of primary sclerosing cholangitis (PSC) were studied clinico-morphologically. In puncture liver biopsies, sclerosis of walls of big ducts and portal tracts was found in 2 cases only; cell infiltration was minimal. Lobular hepatitis with intralobular fibrosis and moderate sclerosis of portal stroma was found in 3 patients, monolobular inactive liver cirrhosis in 4 patients. In all cases mild intralobular cholestasis was found which was followed with a considerable increase of copper and manganese in the liver and serum. The accumulation of a large amount of collagen of different types was observed around bile ducts which ultrastructurally was seen as fibrillar structures and homogeneous substance similar to the basal membrane. The elements of the epithelium destruction were found in foci of the duct basal membrane alteration, in the absence of cell infiltration. Progressing fibrosis of both portal tracts without inflammation and individual segments of the bile ducts and the intralobular stroma is at the basis of PSC.