Biomedical subjects

M Uyama

Publications and source records attributed to M Uyama.

At least 145 records · Page 8Linked to original sources

PubMed1989

[Pathologic response of the weak damaged retinal pigment epithelium (RPE)--affected by sodium iodate (NaIO3)].

We examined the cellular responses of the retinal pigment epithelium (RPE) damaged by sodium iodate. RPE was damaged by intravenous administration of sodium iodate, 10mg per kg body weight, in rats. This dose of the agent damaged RPE weakly. Twenty-four hours after the administration of sodium iodate, polystyrene particles were injected into the subretinal space trans-sclerally. Rats were sacrificed at 6 hours to 4 days after injection of particles. Twenty four hours after injection of sodium iodate, RPE were weakly damaged. The cell organelles were swollen and ruptured, but cell structures were not destroyed. Then particles were injected into the subretinal space, RPE did not phagocytize the particles until 24 hours after the injection of particles. After 48 hours, RPE showed proliferation. After 4 days, RPE formed thick multilayers in the subretinal space and transformed to spindle shapes, and RPE underwent metaplasia to fibroblast-like cells. However proliferation of RPE was not marked. RPE cells weakly damaged by sodium iodate showed delay in phagocytosis of the particles and decrease in proliferation and metaplasia to fibroblast-like cells.

Animals↗

PubMed1989

[Pathologic response of the regenerated retinal pigment epithelium (RPE)--affected by sodium iodate (NaIO3)].

Phagocytosis, proliferation and metaplasia to fibroblast-like cells in the regenerated retinal pigment epithelial cell (RPE) were examined after damage caused by administration of sodium iodate. The solution of sodium iodate (40 mg/kg) was given in a single intravenous injection in rats. Three days after injection, RPE showed marked necrotic damage, but in 2 weeks flat regenerated RPE with short microvilli and no basal infolding were seen on Bruch's membrane. Polystyrene particles were then injected into the subretinal space. The rats were sacrificed 6 hours to 4 days after injection of the particles. The regenerated RPE showed phagocytosis within 6 hours. After 48 hours, they showed multilayer proliferation. After 4 days RPE transformed to spindle-shaped fibroblast-like cells. However proliferation and metaplasia of RPE markedly decreased. The results showed significant decrease in the function of regenerated RPE-cells as a result of their damage.

Animals↗

PubMed1989

[Experimental retinal branch vein occlusion].

Experimental retinal branch vein occlusion was produced in monkeys (macaca irus) by dye laser photocoagulation (yellow wavelength 577nm The 920 ARGON/DYE Laser System, Coherent Radiation). The Clinical process was observed based on ophthalmoscopic and fluorescein angiographic alterations which occur during the natural history of experimental branch vein occlusion. Immediately after occlusion, venous dilatation, retinal edema and punctate hemorrhage, were recognized by ophthalmoscopy, and leakage of dye from postcapillary venules, followed later by additional leakage from large veins were observed frequently by fluorescein angiography. Circulatory disturbances remained over 3-4 days, and the retinal branch vein occlusion were persisted. Ten days later, a non-perfusion area was observed by fluorescein angiography. More than 1 year later, these nonperfusion area remained.

Animals↗

PubMed1988

Serum lipid levels in elementary and junior high school children and their relationship to relative weight.

Serum lipid levels were measured in 2,626 schoolchildren ages 7 to 15 years in three elementary schools and one junior high school in a suburban area of Osaka during 1984-1985. The mean cholesterol levels increased with age in boys ages 7 to 10 years (from 156 to 177 mg/dl) and then decreased at age 13, after which the levels again increased slightly until age 15. Girls showed a similar tendency with a peak at age 10 and a minimum at age 12. Cholesterol levels were significantly lower in junior high school boys (a mean of 154-161 mg/dl for ages 13-15 years) than in girls of the same age or in boys and girls ages 10 to 12 years in the upper grades of elementary school. Cholesterol and triglyceride levels tended to be lower or the high-density lipoprotein cholesterol levels higher in elementary schools where boys and girls engaged in physical exercise than in schools where the children were not strongly encouraged to exercise. About 50% of the hypertriglyceridemic children were obese.

Adolescent↗

PubMed1988