Search PubMed⌕ Search

Biomedical subjects

M Unger

Publications and source records attributed to M Unger.

At least 73 records · Page 4Linked to original sources
PubMed1984

Organochlorine compounds in human breast fat from deceased with and without breast cancer and in a biopsy material from newly diagnosed patients undergoing breast surgery.

Epidemiological studies have related the incidence of mammary cancer to the dietary intake of fat and/or meat. Since organochlorine compounds (e.g., polychlorinated biphenyls (PCB) and DDT (and its metabolite DDE] are accumulated in the adipose tissue it was tempting to suggest a relationship between levels of PCB and "DDT" (i.e., DDT + DDE) in breast fat tissue and the occurrence of mammary cancer. To elucidate this theory, the organochlorine levels of 14 breast fat tissue samples from breast cancer patients and similar samples from 18 deceased mammary cancer patients were compared to that of 21 similar samples from noncancer patients and finally to adipose tissue samples from 35 non-cancer autopsy specimens. No significant differences were traced. Thus it seems that the accumulation of PCB and DDT measured in breast fat tissue do not relate to the occurrence of mammary cancer.

Adipose Tissue↗
PubMed1984

One hundred neodymium-YAG laser ablations of obstructing tracheal neoplasms.

Forty patients with obstructing, nonresectable tracheal neoplasms underwent 100 ablations with the neodymium-yttrium-aluminum garnet (YAG) laser. The laser allows bloodless resection and vaporization of tumors. Unlike the carbon dioxide laser, the neodymium-YAG laser can be used with the flexible bronchoscope and has an excellent effect on coagulation. Thirty-four patients had primary lung malignancies (epidermoid in 24); 4 had metastatic malignancies; and 2 had benign lesions. Results have been excellent in 22, fair in 10, and poor in 8. No patient has died or had a deleterious result. Complications have occurred in only 1 of 89 ablations done with the flexible bronchoscope. We believe that the neodymium-YAG laser is effective in opening major tracheal or bronchial obstructions and offers substantial symptomatic improvement in patients who are short of breath. Although this treatment is only palliative, the results have been excellent in more than half of the patients.

Aged↗
PubMed1984

Introduction to laser surgery.

Since the first operational laser was produced in 1960, the types and applications of lasers in many fields of medicine have increased dramatically. Many surgical techniques, especially with the CO2, argon, and Nd:YAG lasers, are described and illustrated in the articles in this issue. Current studies involving dye lasers and hematoporphyrin derivative (HPD) are discussed and evaluated.

Bronchoscopy↗
PubMed1984

Safety considerations and safety protocol for laser surgery.

The critical importance of laser safety depends on a precise knowledge of the physics of each type of laser and on the tissue effects each type produces in the constantly changing environment during surgery. The considerations involved in using the most common lasers--safety guidelines, general protocol, and specific measures--are outlined.

Anesthetics↗
PubMed1984

Bronchoscopic utilization of the Nd:YAG laser for obstructing lesions of the trachea and bronchi.

The combination of recent technological developments in earlier detection of lung cancer, together with the simultaneous introduction of new palliative therapeutic tools, including the Nd:YAG laser, offers new hope in the treatment of lung carcinomas. Endobronchial usage of the Nd:YAG laser has provided a new technique to treat otherwise untreatable, obstructive malignant tumors, as well as the means to avoid the need for more extensive surgical procedures for benign lesions. It is important to quantify and translate this information to advanced science for optimal development and use.

Bronchial Diseases↗
PubMed1983

Epithelial cell types and their evolution in the rat mammary gland determined by immunological markers.

We have used immunological reagents for characterizing epithelial cell types in the adult rat mammary gland. Some were sera against purified proteins; others were monoclonal antibodies to mammary cells. On the basis of marker distribution we have identified 10 different cell types. We have established the developmental connection between these types by adopting the principle that cells displaying the same markers are directly related to each other. The results concur with those previously obtained by studying the growth response of mammary cells to the hormonal changes of the estrus cycle.

Animals↗
PubMed1983

[Legal bases and institutions for non-industrial vocational rehabilitation].

Responsibility in the field of non-industrial vocational rehabilitation is divided between the public law social security institutions, and the rehabilitation facilities which, formally, come under private law. The legal bases governing the relationship among financially responsible social security institution - rehabilitee - rehabilitation facility have as yet not been determined by normative legislation. This fact gives rise to difficulties in dealing with the legal issues involved. Rehabilitation services are delivered by facilities for vocational training or re-training, as well as workshops for the disabled. Since the 20th pension adjustment act has come into effect, the most important financially responsible social security institution has been the Federal Employment Institute.

Adult↗
PubMed1981

Generation of fibroblast-like cells from cloned epithelial mammary cells in vitro: a possible new cell type.

We have isolated clonal cell lines from a nitrosomethylurea-induced mammary tumor in Wistar--Furth rats. The epithelial-like cells of these lines give rise to fibroblast-like cells. A study of several markers showed that the epithelial-like cells are similar to epithelial mammary cells. The fibroblastic cells, however, were similar to stromal cells, except for the production of collagen IV. The events occurring in these cultures are identical to those observed in previously isolated mammary cultures [Bennett, D. C., Peachey, L. A., Durbin, H. & Rudland, P. S. (1976) Cell 15, 283--298], suggesting their generality. The fibroblast-like cells generated in culture may be a hitherto unrecognized type of mammary cell.

Animals↗
PubMed1980

Protein A as an immunoadsorbent in radioimmunoassay: usefulness in a rapid assay for urinary luteinizing hormone.

A staphylococcal cell wall protein, designated protein A, is known specifically and rapidly to bind to immunoglobulin G. We have utilized this protein as an immunoadsorbent to separate antigen-antibody complexes from free antigen in a rapid 6-hour radioimmunoassay for urinary human luteinizing hormone (hLH). We have further documented the efficacy of this system and the optimal conditions for this assay. The ability of this assay to provide rapid and reliable measurements of hLH in timed urinary specimens provides a useful tool for determination of the preovulatory LH surge and prediction of the time of ovulation in women.

Antigen-Antibody Complex↗