Serum gamma-globulin and lymphoid tissue in the germfree rats.
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Biomedical subjects
Publications and source records attributed to M Ukai.
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The effects of alpha-neo-endorphin on mouse behavior were investigated by using a multi-dimensional behavioral analyser (Animex II) which classifies animal's movements into nine degrees. The intracerebral injection of alpha-neo-endorphin (30 micrograms) significantly decreased the 1/1, 1/2 and 1/4 sizes of movement (linear locomotion and rearing) within 15 min after injection. None of the effects were significantly affected by naloxone even at high doses. The results suggest that a behaviorally active site within the alpha-neo-endorphin sequence is capable of quite potent but nonopiate effects.
The effect of beta-neo-endorphin on mouse behaviors were examined using multi-dimensional behavioral analyser. The intracerebral injection of beta-neo-endorphin (30 micrograms) decreased the ambulation. However, the decrease in the ambulation was not antagonized by pretreatment with 2 and 4 mg/kg doses of naloxone. These results suggest that the decrease in the ambulation induced by beta-neo-endorphin is not mediated by opioid receptors in the brain.