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Biomedical subjects

M Ueki

Publications and source records attributed to M Ueki.

At least 235 records · Page 13Linked to original sources
PubMed1984

[A statistical study of management based on prognostic factors after surgical treatment for cervical carcinoma].

In order to improve the therapeutic results after surgical treatment for cervical carcinoma, 236 patients treated from 1969 to 1976, who could be followed up for five years, were analyzed retrospectively. Various prognostic factors were studied by principal component analysis (quantification method III), and criteria of risk of recurrence were established. Using the discriminant function obtained, another series of 246 patients treated surgically experienced from 1977 to 1982, whose clinical stages were Ib or more, were divided into three groups according to the risk of recurrence and were managed accordingly. The patients in groups II and III, in whom recurrence was possible, received continuous adjuvant chemotherapy with Tegafur (400-600mg/day). The results obtained were as follows. In the principal component analysis, coefficients for the clinical stage, invasion into the parametrium, location of carcinoma and invasion into the uterine body were high on the X1-axis, considered to represent the tumor volume. On the X2-axis, considered to represent the tumor biological characteristics, coefficients of the histological type, CPL classification and lymph node metastasis were high. The risk of recurrence was calculated by the following discriminant function; Z = 0.810X1 + 0.710X2. The values obtained were Z less than 0.053 in group I, 0.053 less than or equal to Z less than 0.376 in group II and Z greater than or equal to 0.376 in group III. Using the equation, 246 cases from 1972 to 1982 were prospectively divided into three groups.(ABSTRACT TRUNCATED AT 250 WORDS)

Adenocarcinoma↗
PubMed1983

The importance of determining stable glycosylated hemoglobin in diabetics: confusions are caused by the nomenclature of glycohemoglobin as HbA1C or HbA1 in its evaluation.

Specimens of HbA1C from human hemolysate contain more than six minor components which cannot be separated by conventional methods. These components have differing characteristic properties and their levels fluctuate depending on the time the blood is drawn and the method of sample preparation used. HbA1C exhibits unreasonable fluctuation and unexpectedly high levels and is therefore not an accurate indicator of long-term blood glucose control. The six components of HbA1C were resolved by our new chromatographic technique using IEX-530, and designated by their eluting position and properties; HbF6, L-GHb7, St-GHb8, L-GHb9, Fr10, and Fr11. HbF6 was alkaline resistant. L-GHb7 and L-GHg9 were easily removed by treatment with saline or semicarbazide and increased after incubation with glucose. The level of L-GHb7 in the blood showed rapid and varied fluctuation on OGTT in both diabetics and control subjects. More than 2% HbF6 and L-GHb7 was present in 13.3% of the control group (n = 57) and in 51.4% of the IDDM group (n = 45). St-GHb8, which was a major component of HbA1C, was not affected by pretreatment with saline, semicarbazide or glucose in vitro. The level of St-GHb8 in the blood showed little change on OGTT. HbA1C, hitherto referred to as one stable component, is an incorrect term used to denote the index of long-term blood glucose control. It is important and warranted to use the level of stable glycohemoglobin (St-GHb8) in future determinations following proper analytical methods.

Blood Glucose↗
PubMed1983

Effective bromocriptine treatment of a pituitary macroadenoma during pregnancy.

A 32-year-old woman with 5 years of oligomenorrhea and 2 years of amenorrhea became pregnant after ovulation induced by clomiphene citrate, human menopausal gonadotropin, and human chorionic gonadotropin. Although there were no neurologic or ophthalmologic symptoms before pregnancy, ptosis and diplopia developed progressively from 14 weeks' gestation. Physical, radiologic, and laboratory examinations revealed hyperprolactinemia with pituitary macroadenoma. In an attempt to delay surgery, 7.5 mg bromocriptine was administered daily. The serum prolactin level was lowered and clinical symptoms improved with bromocriptine treatment. The pregnancy continued uneventfully and normal twins were born at 39 weeks' gestation. Two weeks after delivery, a transsphenoidal hypophysectomy was performed.

Adenoma, Chromophobe↗
PubMed1982

[Clinical diagnosis of well differentiated cervical adenocarcinoma with plentiful mucous secretion].

Six cases of cervical adenocarcinoma with plentiful mucous secretion were recently experienced. They were clearly distinguishable from the majority of adenocarcinoma without plentiful mucous secretion from the standpoint of clinical and colposcopic findings. As common features deduced from clinical and colposcopic findings, it could be pointed out that portio vaginalis become swollen as a whole showed resiliency as of a rubber ball, and that erosion widespread over nearly entire surface of portio vaginalis is accompanied with a plentiful mucus. On the surface of erosion was found neither localization of ulcer, nor necrosis and nor bleeding trend even in cases under progressing. Colposcopic findings were distinguished with features of papillea-, net-and transformation zone-like, and mixed type. On the other hand, all the cases were evaluated cytologically to be positive with difficulty. And they were histologically well differentiated adenocarcinoma with plentiful mucus. The distinctive feature in the clinical and colposcopic findings identified for the cases of well differentiated adenocarcinoma with a plentiful mucus was evaluated to be useful means to assist the diagnosis of cervical adenocarcinoma.

Adenocarcinoma, Mucinous↗
PubMed1982

[A preliminary report of computerized ultrasonography in obstetrics and gynecology: a new technique of C-mode (author's transl)].

UNLABELLED: In order to obtain a three-dimensional ultrasonogram as a first step for a general visualizing diagnosis, a new computerized ultrasonography was tried with patients from our obstetric and gynecological department, with the following results: 1. Time required: Collection of data for the three-dimensional part measuring 17 X 17 X 8.5cm took 17 seconds (Scanning time), and formation of the 32-image longitudinal sections and coronal sections (C-mode) took 46 seconds and 1 minute 54 seconds, respectively. Formation of the 64-image longitudinal sections and coronal sections (C-mode) took 1 minute 20 seconds and 3 minutes 20 seconds, respectively. 2. Images: The recorded and reproduced images were identical to the originals macroscopically and even as indicated on the line printer. The coronal images (C-mode) and the longitudinal images could well stand practical use. 3. Reproduction of images: All data were stored on magnetic tape which could be processed as needed. 4. CLINICAL RESULTS: (a) In obstetric patients, the images enabled us to confirm the location and expansion of the placenta and fetus more clearly. (b) In gynecological patients, it proved to be easy to get a whole view permitting better comprehension of the tumor shape, its internal components and its relation with the surrounding organs in a three-dimensional way.

Adult↗
PubMed1980

[Diagnostic colposcopy of adenocarcinoma of the cervix uteri (author's transl)].

Although frequency rate of adenocarcinoma of the cervix is about 5% or over in cervical carcinoma, colposcopical studies of this lesion have never been reported systematically. We observed the colposcopic findings of 52 cervical adenocarcinoma cases. Resemblances in the findings between colposcopy of the lesion and hysteroscopy of corpus carcinoma were examined in order to confirm diagnosis. And the points differentiating the lesion from other lesion with similar findings were noted. In early cases, papillary findings (Cad), transformation-like findings (Tad), mixed findings, granulation-like findings (Gr), columnar epithelium (C) and atypical vessels (aV) were observed. The lesion tended to bleed and secrete mucus. Glomerulus and tendrilous vessels were seen in the papillaries, and roo-like, wastethread-like, tendrilous and corkscrew-like vessels outside the papillaries. In advanced cases, the lesions tended to necrotic mass and the surface collapsed. White epithelium, mosaic and punctation were not observed in the pure adenocarcinoma cases but were observed in some adeno-squamous carcinoma cases. These surface and capillary characteristics resembled the hysteroscopic findings of corpus carcinoma. The papillary findings resembled some squamous carcinoma findings, papilloma and columnar epithelium. We differentiated the lesion by color, luster, degree of alteration after application of acetic acid, shape of papillaries, nature of bleedings, secretion of mucus, formation of necrotic mass, surface degeneration and vessel types.

Adenocarcinoma↗