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Biomedical subjects

M Ueda

Publications and source records attributed to M Ueda.

At least 1,441 records · Page 80Linked to original sources
PubMed1980

[Alteration of biogenic amines, serotonin, histamine and polyamines, in cases of diarrhea induced by various cathartics (author's transl)].

Effects of various cathartics on charcoal transport, permeability of blood vessels and biogenic amines (serotonin (5-HT), histamine (His), polyamines) in the small intestine of mice were investigated. Diarrhea was induced in mice by oral administration of magnesium sulfate, mannitol, dioctyl sodium sulfosuccinate (DSS), castor oil and pilocarpine. In diarrhea following ingestion of magnesium sulfate and mannitol, vascular permeability in the intestinal membrane accompanied release of His from the small intestine, but such was not so when diarrhea was induced by DSS and castor oil. In diarrhea induced by various cathartics, 5-HT and His were apparently not related to intestinal motility. Thus, alteration in polyamine metabolism in the small intestine may exert an influence on transport of substances in cases of diarrhea in mice.

Animals↗
PubMed1980

The increase in permeability of postcapillary venules in lymph nodes subjected to the regional graft-versus-host reaction.

The changes in permeability of blood vessels in the draining lymph nodes of the footpads undergoing a regional graft-versus-host, host-versus-graft, or antisheep erythrocytes reaction were examined 30 minutes after intravenous injection of Pelikan Ink. Massive leakage of carbon particles was seen only in the postcapillary venules where endothelial cells became flattened. This was observed in lymph nodes 3 to 7 days after induction of the regional graft-versus-host reaction and occurred mainly through intercellular gaps in the endothelium. This transient increase in permeability of postcapillary venules was apparently independent of cellular emigration. No obvious increase in carbon permeability was observed in lymph nodes subjected to the regional host-versus-graft reaction, whereas the uptake of cellular and noncellular elements of the blood by endothelial cells of postcapillary venules was greatly increased. There was no increase in carbon permeability in antisheep erythrocyte-stimulated lymph nodes.

Animals↗
PubMed1980

[Comparative studies on the hemodynamic effects of dobutamine, dopamine, and isoproterenol in dogs in experimental shock (author's transl)].

Cardiovascular effects of dobutamine (DOB), isoproterenol (Iso), and dopamine (DA) were compared in Beagle dogs weighing 6.8 to 11.6 kg under experimental shock produced by ligation of the left coronary arteries and intravenous administration of hexamethonium-Br (10 mg/kg). Intravenous infusion of DOB (1 approximately 20 microgram/kg/min) dose-dependently improved the hemodynamic state of shock by increasing left ventricular dp/dt (LV dp/dt), cardiac output (CO), and blood pressure. These improvements were also observed with the infusion of DA (20 approximately 40 microgram/kg/min). However, the improvement with Iso (0.01 approximately 0.2 microgram/kg/min) was incomplete because of the marked fall of total peripheral resistance. Both DOB and DA increased the venous return, pressure in the inferior vanae cavae, and pressure difference between venous pressure and left ventricular end diastolic pressure. It was presumed that these effects were related to the stimulation of the alpha receptor in the venous system, in addition to the marked positive inotropic effects by DOB or DA. Iso increased significantly only the venous return. Although increases of coronary flow with DOB and DA are probably mainly due to an increase of myocardial oxygen consumption, the increase of coronary perfusion pressure also may contribute to the increase of coronary flow. As a result, myocardial oxygen balance was improved with DOB or DA. alpha stimulation in the venous system as well as beta 1 stimulation apparently contributes to improvement of the deteriorated hemodynamic state, in experimental shock, as induced in dogs.

Animals↗
PubMed1980

A case of Ménétrier's disease accompanied by severe hypogammaglobulinemia.

We describe a case of Ménétrier's disease accompanied by severe hypoproteinemia with marked decrease of gamma globulin. Roetogenograms and endoscopic findings of the upper gastrointestinal tract demonstrated enlarged gastric rugae and multiple small protuberances of the duodenal mucosa. Histological findings a gastric biopsy specimens showed mucosal thickening and hypertrophy. Plasminogen activator activities were increased in both gastric and jenunal mucosal biopsy specimens. Severe hypoproteinemia was proven by the Gordon test and by determination of protein content of gastric juice to be due to protein loss into the gastric lumen.

Adult↗
PubMed1979

Oncofoetal antigens of human trophoblast.

Rabbits immunized with human trophoblast cell membranes produced antibodies that were detected, by immunofluorescence, to react with normal human tissues, and, by complement-mediated cytotoxicity, with several transformed human cell lines. Absorption with trophoblast abolished all of these reactions, whereas multiple absorptions with lymphocytes, liver or kidney failed to remove reactivity with either trophoblast or certain transformed cells. To further identify the antigens responsible for these antibodies, rabbits were immunized with a chromatographed fraction of deoxycholate-solubilzed membranes prepared from KCl-extracted, ultracentrifuge-prepared trophoblast microvilli. The resultant IgG antibody reacted specifically with syncytiotrophoblastic membranes in sections of human placentae, in addition to recognizing the membranes of viable Chang liver, AV3, HEp-2, Sw/156 (kidney) and Sw/527 (breast) cells. That normal tissues, baboon or monkey placentae, and HeLa or Daudi cell lines did not react with this antibody, indicates the presence of species- and organ-specific antigens in human trophoblast, as well as the existence of trophoblast cross-reactive antigens on some transformed cells. The selective localization of these antigens at the interface of the materno-foetal graft suggests that they function biologically in the host-parasite relation of human pregnancy; their appearance on many transformed cells implies a similar function in the host-parasite relation of some human cancers.

Animals↗
PubMed1979

Three-dimensional display of ultrasonic images using a fly's-eye lens.

In order to form a three-dimensional image from a set of two-dimensional cross-sectional ultrasonic images, a simple method making use of a fly's-eye lens in proposed. The depth perception obtained from the reconstructed image using the fly's-eye lens is analysed and an optical configuration that maximizes the depth perception is devised. With this configuration, the synthesis of a three-dimensional image is performed by using a simple object. Results of the experiment show clearly the three-dimensional aspect of the reconstructed image.

Data Display↗
PubMed1979

Complement proteins and macrophages. 1. Quantitative estimation of factor B produced by mouse peritoneal macrophages.

Cobra venom factor was used for the detection of factor B synthesized by mouse peritoneal macrophages. This method was shown to be specific for factor B assay by neutralization by antimouse factor B antibody. The amount of factor B in the culture supernatant, assessed by this method, was found to be dependent on the medium used for cultivation of macrophages. The addition of 25% L cell-conditioned medium to minimal essential medium (LCM-MEM) enhanced the production of factor B and also of lysozyme. Kinetic analysis in LCM-MEM showed that factor B produced by 6 x 10(4) cells/cm2 increased up to 72 hr and reached a plateau at 96 hr. The amounts of factor B and lysozyme produced in LCM-MEM depended upon the number of macrophages. Production of factor B was completely inhibited by 1 microgram of cycloheximide per ml and was restored by its removal.

Animals↗
PubMed1979

Origin of small RNA in von Magnus particles of influenza virus.

A clone of recombinant virus obtained from the cross between WSN and Hong Kong strains of influenza virus gave rise to progeny containing predominantly von Magnus particles. In the electropherogram of virus RNA, the P3 gene was markedly diminished, and a new species of RNA (extra RNA) was present in addition to eight gene segments. The origin of the extra RNA was studied by two-dimensional gel electrophoresis of T1 RNase-generated oligonucleotides. Four out of five large oligonucleotide spots present in the extra RNA matched to those contained by the P3 gene. It was concluded that the extra RNA was derived from the P3 gene probably by deletion. The possible origin of the spot which was present in the extra RNA but not in eight gene segments including P3 was discussed.

Defective Viruses↗
PubMed1979

Vectorcardiogram of complete right bundle branch block with left axis deviation by the Frank and Kimura systems.

Vectorcardiogram (VCG) recorded by both the Frank and Kimura systems were examined in 45 patients with complete right bundle branch block (RBBB) and left axis deviation (LAD) to investigate the relationship seen on electrocardiogram (ECG) between RBBB with LAD and bilateral bundle. The sample included: 13 cases of type SI, SII, SIII, SaVF; 21 cases of type SI, SII, SIII, aVF; and 11 cases of types SI, SII, SIII. VCG recorded by the Frank system were classified into seven types according to the QRS loop pattern on the frontal plane and into three types according to the horizontal plane. The main findings were: (a) In the Frank system the QRS loop in the frontal plane showed a variety of patterns in RBBB with LAD. (b) On VCG of complete RBBB judged complicated by a left anterior hemiblock by the Frank system, the main portion of the QRS loop extended to the left superior or merely to the left in the frontal plane. The direction of rotation and position on the horizontal plane were not consistent. (c) The results of this study suggest the usefulness of the Kimura system as an auxiliary diagnostic technique.

Adult↗