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Biomedical subjects

M U Schuhmann

Publications and source records attributed to M U Schuhmann.

24 records · Page 2Linked to original sources

Brain-stem auditory evoked potential monitoring in experimental diffuse brain injury.

The time course of brain-stem auditory evoked potential (BAEP) changes was investigated using an impact-acceleration trauma model in 23 spontaneously breathing rats. Intracranial pressure (ICP), arterial blood pressure and respiratory rate were monitored. The experiments were terminated at four hours after trauma. No significant changes in intracranial pressure (ICP) occurred following the impact. After a short increase, blood pressure returned to baseline values within 5 min. Transient apnea was not followed by prolonged respiratory depression. Diffuse closed head injury (CHI) did not result in general, unidirectional changes of peak latencies or amplitudes of auditory evoked responses. Most BAEP changes developed slowly reaching a maximum at 1 to 4 hours after the injury. In the absence of ICP changes, this pattern reflects secondary ischemia in sensitive brain-stem areas rather than direct traumatic lesions or hypoxia due to respiratory depression.

Animals↗

Traumatic brain injury in the developing rat pup: studies of ICP, PVI and neurological response.

Diffuse brain swelling is a common complication in young victims of a seven head injury but, there is a lack of data on relevant models of injury. We produced diffuse brain injury in 21 day old Lewis rat pups (N = 33) by modifying a recently established weight-drop-model. The trauma threshold, neurological response, histological changes, intracranial pressure (ICP), and arterial blood pressure (ABP) were determined. In addition, the pressure-volume-index (PVI) was measured 15 min before, 2 min, and 1 h after brain injury. In the 1 m/100 g group 4 of 5 rats died, whereas in the 0.5 m/100 g only 4 of 28 died. The PVI increased at 2 min after traumatic brain injury (TBI) but ICP was unchanged, except for a minor increase immediately after injury. Histological studies revealed diffuse neuronal death, predominantly involving the cortex and hippocampus. The results of the present study indicate that determination of ICP in the developing rat pup during and after diffuse brain injury is possible. A 0.5 m/100 g weight-drop-trauma results in a morphologically severe injury but with low mortality. The increase in PVI can be attributed to a decrease of cerebral perfusion pressure (CPP) after injury. However, the absence of a further increase of ICP after injury in the developing rat indicates that this may not be a primary consequence of injury in paediatric patients.

Age Factors↗

CSF dynamics in a rodent model of closed head injury.

Using ICP measurements and the bolus injection technique dynamic parameters of the cerebrospinal fluid system as there are pressure-volume-index (PVI) and resistance to CSF outflow (Rout) were investigated in a new model of diffuse closed head injury (CHI) in the rat. It was found that in the absence of brain oedema and ICP alterations an increase in PVI and Rout was present in the early (4h) period following head injury. This may be indicative for a reduction in cerebral blood flow and cerebral blood volume, both shown previously to occur after CHI. Furthermore an early impairment of CSF absorption mechanisms is evident. To answer the question, whether bolus injection techniques are advisable for clinical routine and whether results might have a predictive value, further investigations covering longer observation intervals and in the presence of secondary insults to the brain are necessary.

Animals↗

Direct magnification technique for cerebral angiography in the rat.

RATIONALE AND OBJECTIVES: The authors evaluated the performance of direct magnification radiography (DIMA) with digital image processing for cerebral angiography in the rat. METHODS: A microfocal x-ray unit with a focal spot of 5 microns was used for cerebral angiography in 10 rats. The animals were examined form x 4 up to x 20 magnification after injection of 0.2 mL x-ray contrast medium into the common carotid artery. RESULTS: Direct magnification radiography technology provides high resolution images and enables the visualization of very small vessels with high quality. It allows the peripheral branches of the middle cerebral artery or the ophthalmic artery to be visualized. Superimposition and noise effects can be excluded with digital subtraction and image processing. CONCLUSIONS: The experiments show that DIMA radiography is a suitable technique for cerebral angiography in the rat.

Animals↗

[Determination of core body temperature. A comparison of esophageal, bladder, and rectal temperature during postoperative rewarming].

OBJECTIVE: The data of 60 postoperatively sedated and ventilated patients were studied for analysis of oesophageal, bladder, and rectal temperatures. The purpose of the investigation was to clarify whether changes of oesophageal temperature are adequately reflected by bladder and rectal temperatures and whether the rate of rewarming has an influence on the accuracy of the latter two sites. METHODS: For temperature recording, a Hi-Lo Temp esophageal stethoscope (Mallinckrodt Medical), a Foley FC400-18 catheter temperature sensor (Respiratory Support Products, Mallinckrodt Medical), and a rectal temperature probe N401 (YSI) were used. Each probe and matching recording unit was calibrated over a range of 30-40 degrees C against a reference quartz thermometer (Hewlett packard Model 2801 A) in a thermostated water bath before the investigation. Five measuring points distributed over the whole period of rewarming were evaluated. Patients were assigned to groups with slow and fast rewarming, respectively. Agreement between the methods of measurement was assessed as described by Bland and Altman. Furthermore, differences between the oesophageal and bladder or rectal temperature were checked at each measuring point for statistical significance using the t-test. RESULTS: In regard to oesophageal temperature, the bladder and rectal temperatures had biases of -0.01 degree C and -0.03 degree C, respectively. Limits of agreement (+/- s) were +/-0.68 degree C and +/-0.82 degree C, respectively. The bias of the bladder temperature was independent of the rate of rewarming (Fig. 3). The bias of the rectal temperature, however, differed in regard to the rewarming rate, being +0.06 degree C in the group with slow rewarming and -0.13 degree C in the group with fast rewarming (Tables 1 and 2, Fig. 1 and 2). These differences were significant for the measuring points 4 and 5 (Fig. 4). CONCLUSIONS: Bladder and rectal temperatures can accurately indicate the oesophageal temperature with a very small bias in postoperatively sedated and ventilated patients. Since the rate of rewarming influences the accuracy of rectal temperature readings, monitoring of bladder temperature seems to be more favourable in the postoperative period.

Body Temperature↗

Cerebellopontine angle lipoma: a rare differential diagnosis.

Intracranial lipomas in an infratentorial and extra-axial location are extremely rare. The presented case of an extensive lipoma of the cerebellopontine angle (CPA) represents 0.05% of all CPA tumors operated on in our department from 1978 to 1996. The lipoma constitutes an important differential diagnosis because the clinical management differs significantly from other CPA lesions. The clinical presentation and management of the presented case are analyzed in comparison to all previously described cases of CPA lipomas. The etiology and the radiological features of CPA lipomas are reviewed and discussed. CPA lipomas are maldevelopmental lesions that may cause slowly progressive symptoms. Neuroradiology enables a reliable preoperative diagnosis. Attempts of complete lipoma resection usually result in severe neurological deficits. Therefore, we recommend a conservative approach in managing these patients. Limited surgery is indicated if the patient has an associated vascular compression syndrome or suffers from disabling vertigo.

Case Reports↗