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Biomedical subjects

M Tsuru

Publications and source records attributed to M Tsuru.

At least 55 records · Page 3Linked to original sources
PubMed1984

Effect of influenza vaccine on warfarin anticoagulation.

Recent studies have indicated that viral infections, influenza vaccination, or drugs that increase interferon synthesis all decrease hepatic drug metabolism. We report a case in which influenza vaccination was temporally related to an increased anticoagulant effect of warfarin. A prospective study evaluating the effect of influenza vaccination on the prothrombin time of eight patients anticoagulated over the long term showed that there was prolongation of prothrombin time of 40%. In a second study, the effect of influenza vaccination on warfarin t1/2 was determined in healthy subjects. No significant effect on warfarin metabolism was observed after vaccination. We conclude that influenza vaccination is associated with increased anticoagulant response in some patients receiving anticoagulants over a long term. This effect appears to be related to some step in the coagulation pathway and not to decreased warfarin metabolism and a subsequent rise in serum concentration.

Adult↗
PubMed1984

[Case of acoustic neurinoma with intratumoral hemorrhage extending to cerebellar hemisphere].

A case of acoustic neurinoma which developed intratumoral hemorrhage extending to the right cerebellar hemisphere, is reported. A 54-year-old man was diagnosed as cerebello-pontine angle tumor, possibly acoustic neurinoma, from typical clinical course, neurological signs and findings of skull X-P and CT scan at the first visit to our out-patient clinic on July 28, 1981. On August 6, 1981, he was transferred to our in-patient ward in emergency because of sudden onset of headache and impairment of consciousness. At emergency admission, he was found to be comatous and CT scan revealed round-shaped high density in the right cerebellar hemisphere, continuing from the right cerebello-pontine angle tumor with enlarged lateral ventricles, which indicated occurrence of intratumoral hemorrhage. At emergency operation, hematoma in the right cerebellar hemisphere was evacuated and the tumor in the right cerebello-pontine angle was partially resected. Microscopically, the tumor was composed of compact, finely fibrillated cells of Antoni A tissues, and loose patterns of Antoni B tissue, being diagnosed as schwannoma, and also abnormal vascular proliferations were identified just adjacent to foci of hemorrhage noted within tumor tissues. The pattern of abnormal vascular proliferations within this tumor were almost identical with telangiectasia. The authors concluded that intratumoral hemorrhage in this case occurred most likely due to disruption of histologically verified abnormal vascular proliferations.

Cerebellopontine Angle↗
PubMed1984

[A case of amaurosis fugax with anomalous origin of the ophthalmic artery and atheromatous stenosis of the external carotid artery].

Amaurosis fugax associated with anomalous origin of the ophthalmic artery without occlusion of internal carotid artery is very rare. We are reporting such a case of amaurosis fugax with anomalous origin of the ophthalmic artery and atheromatous stenosis of the external carotid artery. A 49-year-old-man was referred to our neurosurgical clinic because of transient monocular blindness. The patient was diagnosed as carotid TIA and was treated within aspirin and dipyridamole. In spite of this treatment, he experienced further transient dimness of vision in the right eye, several times during a period of one month. On admission, general, physical and neurological examinations disclosed no abnormality except for a bruit over the right carotid artery. Platelet adhesiveness and aggregation were slightly elevated. Right common carotid angiogram showed marked stenosis of the origin of the external carotid artery and small "sail-like" plaque in the internal carotid sinus. The angiogram also demonstrated that the right ophthalmic artery was originated from the middle meningeal artery through the superior orbital fissure. Since choroid crescent was observed, all the branches of the ophthalmic artery including the central retinal artery were filled by the external carotid system. The right ophthalmic artery was never visualized by the selective internal carotid angiography. Subsequently right carotid endarterectomy was performed without complication. One year later he remains asymptomatic.(ABSTRACT TRUNCATED AT 250 WORDS)

Blindness↗
PubMed1984

[Transcallosal approach to para-ventricular tumors].

Our experience with the transcallosal approach to para-ventricular tumors is reviewed and our operative technique is described. A group of 7 patients with a variety of tumors affecting the lateral ventricle, 3rd ventricle and basal ganglia have been treated using an anterior transcallosal approach. Using a posterior transcallosal approach, we operated upon 2 patients with thalamic tumors. The anterior part of the body of the corpus callosum is divided in the anterior transcallosal approach and the posterior part of the body of the corpus callosum is divided with preservation of the splenium in the posterior transcallosal approach. The division amounting to approximately 2-3 cm is sufficient exposure. With the exception of tumors affecting the basal ganglia, thalamus and anterior 3rd ventricle, complete excision of each lesion was effected. There were no operative deaths. The complications in this group of patients were primarily related to the nature and location of the primary tumor, but four complications were directly related to the transcallosal approach. Venous infarctions occurred in 2 patients and subdural fluid collections occurred in 2 patients. Therefore, planning of the flap placement and the extent of brain retraction must be based on preoperative angiographic assessment of parasagittal venous tributaries. We performed some detailed studies of the interhemispheric transfer of somesthetic and perceptual motor tasks, as well as psychometric testing post-operatively in 2 patients. No significant clinical deficit subsequent to dividing the anterior part of the body of the corpus callosum could be demonstrated. The results and clinical material indicate that transcallosal approach is a safe, feasible alternative in the management of the tumors in these regions.

Adult↗
PubMed1984

[Direct spinal cord and root injury caused by acupuncture--report of 2 cases].

Two cases of the direct spinal cord and root injury caused by acupuncture were presented with a review of eight cases reported previously. Case 1 was 56 years old female who had been developed progressive lumbar pain, which occasionally radiating to the right lateral femoral region, since she had been treated with acupuncture for lumbago 13 months before. Examination revealed the mild sensory impairment on the right lateral femoral area and straight-leg-raising was limited on the both sides. Plain films and myelogram showed the needle between L4/L5 vertebrae and the tip of it stuck in the lumbar root. She recovered after the needle had been removed. Case 2 was 17 years old male who had initially noticed numbness over his left foot after acupuncture for easy fatiguability, which had been progressed stepwise over 2 years, and then examination revealed Brown-Séquard syndrome. Radiological examination showed the needle stuck in the spinal cord between C1/C2 vertebrae and metrizamide CT myelogram disclosed the posterior end of it was in the subarachnoid space. Operative finding revealed a small cavity around the needle in the spinal cord. The needle was removed uneventfully. There was a good recovery of weakness but not of sensation. Although the direct spinal cord and root injury as a complication of acupuncture seems uncommon, our cases show one of a serious complication of acupuncture.

Acupuncture Therapy↗
PubMed1984

[Effect of PS-K on experimental neurogenic tumors in rats induced by ethylnitrosourea].

The effect of PS-K as immunomodulator was studied in Fischer rats bearing neurogenic tumors induced transplacentally by ENU. 114 rats were divided into control and PS-K treated groups. all rats were subjected to an autopsy at death and all of central nervous system were examined macroscopically. Final neurogenic tumor incidence in PS-K treated groups was significantly lower than that in the control group, but distribution of these neurogenic tumors and number of neurogenic tumors in a rat remained unchanged between the control and the each PS-K treated groups. Survival time of PS-K treated groups did not increase than the control group. From these experiments, it might be that induction of neurogenic tumors may be suppressed by administration of PS-K.

Adjuvants, Immunologic↗
PubMed1984

[Efficacy of nidus embolization of large arterio-venous malformation prior to surgical excision].

Although it is undoubted that surgical excision is the ideal treatment for arterio-venous malformation, its large nidus and deep localization make it difficult in some instances. To make surgical procedure easier, efficacy of nidus embolization or of obstruction of feeding arteries by detachable balloon technique is reported. A case presented here is such a case with large arterio-venous malformation which was successfully removed surgically following artificial nidus embolization with silastic spheres. On May 12th, 1983, a 27-year-old housewife was admitted to our department with chief complaints of episodes of alexia, apraxia, and aphasia lasting for a few minutes during 4 years prior to admission. Neurological examination on admission showed no abnormalities. Left internal carotid angiogram taken on admission showed a large arterio-venous malformation in the left parieto-temporo-occipital region fed by three branches of the left middle cerebral artery and two branches of the left posterior cerebral artery (Fig. 2a, 3a). To enable successful excision without neurological deficits, nidus embolization with silastic spheres was performed on June 2, 1983. Forty silastic spheres of 1.5 mm in diameter were injected via a catheter introduced in the left internal carotid artery and a second injection of 48 silastic spheres of 2.0 mm in diameter was performed after confirmation of no stray of silastic spheres in the arteries unrelated to the nidus. Embolization procedure was interrupted after the second injection, because of stray of silastic sphere into the posterior internal frontal artery of the left anterior cerebral artery.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1984

[Effect of dopamine on local cortical blood flow and somatosensory evoked potential in acute stage of cerebral ischemia--basic study].

UNLABELLED: Effect of intravenous injection of dopamine on local cortical blood flow (CBF) and somatosensory evoked potential (SEP) was evaluated using canine cerebral ischemia, which was produced by occlusion of unilateral middle cerebral artery. CBF was monitored with H2 clearance method and SEP was recorded by stimulating ischias nerve of contralateral side and P1 to N1 peak to peak amplitude, V1, out of components of SEP was used as a parameter expressing brain function. Systemic arterial pressure was also measured. Protocol in this study is shown in Fig. 1. RESULTS: 1) As to change of systemic arterial pressure during administration of dopamine (Fig. 2) Systolic systemic arterial pressure was significantly increased at doses of dopamine of 25 and 65 gamma compared to the value obtained before initiation of dopamine injection. There was nearly no increase in mean systemic arterial pressure at doses of 5 and 10 gamma and mean systemic arterial pressure increased by 5 to 15 mmHg at doses of 20, 30 and 25 gamma, without significant increase compared to the value before start of dopamine administration. Pulse rate became significantly wider at doses of 10, 20, 30, 25 and 65 gamma. 2) As to increase of local cortical blood flow (CBF) during dopamine injection (Fig. 3, 5) CBF increased at doses of dopamine of 5, 10, 20, 30, 25 and 65 gamma compared to the one before dopamine injection. However, degree of increase of blood flow was not significant. 3) As to recovery of somatosensory evoked potential (SEP) during administration of dopamine (Fig. 4, 6) SEP was recovered at doses of dopamine of 5, 10, 20, 30, 25 and 65 gamma. Degree of recovery of SEP was significant at doses of 5, 20, 30 and 25 gamma.(ABSTRACT TRUNCATED AT 250 WORDS)

Acute Disease↗
PubMed1984

[The diagnosis and pathogenetic study of syringomyelia].

Thirteen cases of syringomyelia which was confirmed by metrizamide CT myelography (MCTM) were reported. Nine cases were associated with Chiari malformation, and four were idiopathic type. Delayed CTM which were performed in several hours after the metrizamide myelography disclosed not only the existence of the syrinx but its shape and location. From the investigation of their clinical findings together with the appearance of their syrinx on CT scan, the following results were obtained. The syrinx was not always situated centrally within the cord, but had laterality at some spinal level in nine out of thirteen cases. The main laterality of the syrinx seemed to be located in the posterior horn. In the cases which had unilateral dissociated sensory disturbance, the laterality of sensory disturbance corresponded with the side of syrinx. These results suggested the possibility that the intrathecal injected contrast materials entered into the syrinx via the dorsolateral sulcus of the cord rather than via IV ventricle in some cases.

Adolescent↗
PubMed1983

High resolution computed tomography in the diagnosis of cervical disc disease.

In this study, the authors evaluate the importance of computed tomography (CT) in 15 patients who underwent surgical treatment for cervical disc disease. In nine operated on by an anterior approach, all CT examinations were interpreted as positive for disc herniation and correlated precisely with surgical observations. CT demonstrated protrusion of the disc, centrally in four and posterolaterally in five in all of whom disc material was found posterior to the vertebral body. Of six who underwent laminectomy, either thickening or calcification of the ligamentum flavum was demonstrated by CT and confirmed at surgery in five. Vacuum phenomenon in the intervertebral space and hypertrophy of the intervertebral joint were not infrequently associated. CT can exactly delineate cervical disc lesions and associated pathological changes.

Cervical Vertebrae↗
PubMed1983

Effect of cholestyramine and colestipol on the absorption of phenytoin.

The hypocholesterolemic cation resins, cholestyramine and colestipol, have variable effects on the absorption parameters of a number of lipophillic, anion drugs. Because of the unpredictable nature of this interaction, we have assessed in human volunteers the effect of these resins on the rate and total absorption of phenytoin. Our results indicate that these resins do not affect the absorption parameters of phenytoin and that special care does not have to be exercised when these agents are co-administered.

Adolescent↗
PubMed1983

Computed tomographic findings of vacuum phenomenon in cervical intervertebral disks.

A gaseous collection in the intervertebral space, or the vacuum phenomenon, was observed on computed tomograms in as many as 30% of the patients with cervical disk disease. The condition most frequently occurred at the level of C5-6. The gas tended to accumulate more often at the marginal region of the intervertebral disks, the level at which marked degeneration was seen; thus, it may be related to cracks within not only the nucleus pulposus, but also in the annulus fibrosus.

Aged↗