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Biomedical subjects

M Trojani

Publications and source records attributed to M Trojani.

At least 91 records · Page 5Linked to original sources
PubMed1981

The prognostic significance of specific histologic features of carcinoma of the colon and rectum.

The prognostic significance of several histologic features of the primary tumors and regional lymph nodes was analyzed in 82 consecutive patients with carcinoma of the colon and rectum. Three criteria were shown to have a statistically significant favorable impact on prognosis: Dukes' A or B stage, the absence of mucinous components and the presence of lymphoplasmocytic infiltration in or around the tumor. Based upon the number of these criteria present, we were able to separate the patients into three distinct prognostic groups. We suggest that such a grouping is simple and should be considered in the design and analysis of future adjuvant trials done for carcinoma of the colon and rectum.

Adult↗
PubMed1981

[Contribution of drill-biopsies to pre-treatment investigation of breast adenocarcinomas (author's transl)].

The sensitivity of drill-biopsies (Rousseau's technique) was studied before using them routinely in pre-treatment investigation of breast adenocarcinomas. Results of histological examination, and estrogen (ER) and progesterone (PR) receptors levels obtained preoperatively by this technique, were compared with those from the corresponding mastectomy or tumourectomy specimens in 85 cases. Cytological examination of the various specimens, performed on prints, was used to compare their cellular density. Measurement of receptors included the determination of cytosolic and nuclear sites, and was performed by the single point dextran charcoal method. The limits of positivity established for ER and PR were 10 and 15 fM/mg protein respectively. The results showed sensitivity of 91.8 p. cent for pathology examinations; furthermore, the Scarff-Bloom-Richardson histoprognosis grading could be performed satisfactorily on drill-biopsy specimens. No significant difference was observed between the percentage of positivity for ER and PR from surgical and drill-biopsy specimens. Good correlation existed between values obtained from drill-biopsy and from surgery both for ER (r = 0.86, p less than 10(-5)) and PR (r = 0.86, p less than 10(-5)).

Adenocarcinoma↗
PubMedDate not supplied

Distinctive clinical features between lymphoblastic and immunoblastic non-Hodgkin's malignant lymphomas (Kiel's classification) in a series of 141 patients.

Out of a series of 427 NHML based on the Kiel classification and without previous treatment, 186 were of high grade malignancy and among them were 83 lymphoblastic (LB) and 58 immunoblastic (IB) lymphomas which were included in this study. The LB and IB, which represent the majority of high grade NHML, were compared regarding their clinical features and courses. Eight main criteria were significantly different between these two groups: age of patient, immunological history, mediastinal and pleural involvement, primary or secondary involvement of the bone marrow, secondary leukaemia, secondary meningeal involvement, and involvement of the facial region. Some of these differences (mediastinum and meningeal involvement) are related to subtypes within LB. The differences between these two groups suggest that different treatment programs may be warranted.

Adult↗
PubMedDate not supplied

[Histology and prognosis of cutaneous malignant melanomas. Study of 50 cases].

50 cases of malignant melanoma of the skin followed up for more than 5 years are analysed according to histological criteria established at the Sydney conference. Two groups of 25 patients, one in which the course was favourable and the other in which it was not, are compared. Positive conclusions in terms of the prognosis may be drawn.

Adult↗
PubMedDate not supplied

[Course of follicular lymphomas in a series of 281 patients].

From 1963 to 1988, 281 patients suffering follicular lymphomas and without previous treatment were treated in the same institution. One hundred and thirty three had a localized disease (72 stages I, 61 stages II) ans 148 an extended disease (83 stages III and 85 stages IV). In the absence of dramatic therapeutic improvement quite all patients were treated in a homogeneous manner with radical radiotherapy for localized disease and palliative chemotherapy for extended ones. Median follow-up is 9 years. Ten year overall survival is 38% and relapse free survival 29.5%. Multivariate analysis show two main prognosis factors: age (+ or - 60 years) and tumoral mass (as shown by stage or number of involved area). Survival depends also on complete remission. Age and tumoral mass allows us to define three prognosis groups: favorable, intermediate, unfavorable. These groups justify different therapeutic approach and different proposals for prospective therapeutic trials.

Age Factors↗
PubMedDate not supplied

[The request for surgical biopsy in mammography. Apropos of 140 verified cases].

The authors present a series of 140 patients who underwent surgical biopsy guided by an isolated anomaly on mammography without any clinical sign. 27 cases presented an opacity with a long axis less than 10 mm, 59 cases presented isolated areas of micro-calcification and 54 cases presented images of focal distorsion of the glandular architecture. By means of pre- and intra-operative radiographic guidance, the histological analysis of serial sections of these abnormalities was possible in every case, resulting in the diagnosis of 54 cases of benign dysplasia, 31 transitional lesion, including 16 in situ carcinomas and 55 carcinomas, including 34 invasive cancers. The advantage and limitations of this diagnostic approach are analysed. The discovery of a large number of sub-clinical carcinomas, the favourable implications for preservation of the breast and the survival justify the indications for surgical biopsy on the discovery of an isolated mammographic abnormality.

Biopsy↗
PubMedDate not supplied

[Primary choriocarcinoma of the stomach. Immunohistochemistry study of a case and review of the literature].

A rare tumor, primary choriocarcinoma of the stomach occurred in a 68 year-old man. Histologic examination of the tumor revealed two components, choriocarcinoma and adenocarcinoma. The liver metastasis displayed only choriocarcinoma, the lymph nodes metastasis only adenocarcinoma. The diagnosis was confirmed by demonstration of beta HcG in serum and urines by radioimmunoassay and within syncytiotrophoblast cells by immunoperoxidase staining. A review of the literature is done. The pathogenesis is discussed with hypothesis that this tumor represents a form of retro-differentiation of a preexisting carcinoma. However, this diagnosis will only be certain when a metastasis of a non gestational, non gonadal choriocarcinoma will be eliminated.

Aged↗