[Somatostatin and biliary lithogenesis].
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Biomedical subjects
Publications and source records attributed to M Trías.
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The success of laparoscopic cholecystectomy has expanded the scope of laparoscopic procedures and resection of retroperitoneal organs and selected cystic intraadominal masses have been performed by minimally invasive surgical techniques. We report the case of a 45-year-old that presented a retroperitoneal cystic lymphangioma that was successfully excised by a laparoscopic approach. Laparoscopic surgical techniques should be considered for treatment of selected cystic lesions of intrabdominal or retroperitioneal origin.
Laparoscopic cholecystectomy is the treatment of choice for gallstones. A formal contraindication is gallbladder cancer. However, in a great number of cases, this is a previously unsuspected intraoperative finding, and sometimes its first appearance is in acute cholecystitis. We present the case of 67-year-old woman, which presented an unsuspected carcinoma of the gallbladder that developed abdominal wall implants at the umbilical and left hypocondrium site. The success of LC favors the observation of cases similar to that described in this article. Surgeons who operate using laparoscopic techniques should bear this possibility in mind and practice an extemporaneous biopsy at the slightest suspicion of malignancy, and, if it is confirmed, the operation should be continued as an open one.
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Radioimmunoscintigraphy (RIS) of colorectal carcinoma with a 111In-labelled anti-TAG-72 monoclonal antibody (CYT-103) has been performed in 24 patients with five primary lesions and 10 suspicious of recurrence (in one of these patients two RIS were made). Histopathological confirmation of the disease and surgical liver examination were carried out in all primary tumours and in 12 possible recurrences. In the remaining eight patients a final diagnosis was established according to the clinical course and other diagnostic procedures. Planar and tomographic scans were obtained at 48 and 72 h postinjection in all patients. All primary tumours were detected by RIS. In the group with recurrences confirmed pathologically the results were nine true positive, two true negative and one false positive in a patient affected only with liver disease. The nine true positive studies corresponded to four positive by computed tomography (CT), four negative by CT and one nonconclusive by CT. Surgical liver examination results were 15 true negative and two false negative. No correlation was found between serum levels of carcinoembryonic antigen or TAG-72 and the detection of the lesions. In 10 patients human anti-mouse antibody (HAMA) levels were studied. In conclusion, RIS with an anti-TAG-72 monoclonal antibody is a useful technique for the study and localization of colorectal tumours, mainly in cases of recurrence, being also indicated in patients with normal TAG-72 serum levels.
The staging of anal canal carcinoma is essential to establish the surgical procedure, either a local excision or abdominoperineal resection. In addition to the conventional studies we have used the anorectal endosonography in seven patients with carcinoma of the anal canal. The preoperative staging was done according to the UICC classification. The endosonography gave significant information of the anal anatomy to assess an accurate diagnosis in six patients, two of them had tumors invading the vagina. In one case, the ultrasound image was underestimated. Overall accuracy of the endosonographic assessment was 85.7 percent. Anorectal endosonography correctly assesses the anatomy layers of the anal canal and offers a good tumor's staging.
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The findings of three surveys and three studies used by Profamilia to evaluate and improve their voluntary female sterilization program are presented. The surveys measured sociodemographic characteristics of users, factors behind the sterilization decision, and user satisfaction with the operation in the short run and over time. The studies explored methodologies for more accurate cost-effectiveness analysis. Results of the projects were used by Profamilia management to identify areas of program strengths and weaknesses and to implement operational changes.
After the spread of laparoscopic cholecystectomy, minimally invasive surgery has been applied to other organs such as the pancreas. Diagnostic laparoscopy is a very useful tool which provides information in conjunction with other instruments such as ultrasonography and computed tomography in the study of pancreatic cancer. Laparoscopic ultrasonography improves the sensibility and specificity of laparoscopy alone in predicting resectability. Although experimental cases of pancreatic resection have been described, the majority of patients require palliative treatment. Surgical bypass has a high morbidity rate and nonoperative biliary decompression has become an established treatment for relieving jaundice. However, these techniques are associated with a high rate of recurrent obstruction. Laparoscopic cholecystojejunostomy gives the advantage of definitive bypass with shorter hospital stay, and a gastrojejunostomy can also be performed when duodenal obstruction occurs. Relief of pain is possible with a thoracoscopic splanchnicectomy, which offers good results. Internal drainage for pseudocysts is another new application of laparoscopic surgery which gives excellent results.