Biomedical subjects
Publications and source records attributed to M Toyoda.
We report a case of signet ring adenocarcinoma arising in the ileal part of an ileocystoplastic bladder. Postmortem examination revealed multiple polypoid tumors in the ileal mucosa of the ileocystoplasty invading slightly into the bladder wall. Metastatic lesions were found in the liver, lungs, myocardium, right kidney, pancreas, vertebrae, left epididymis and lymph nodes.
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A 65-year-old man had a tumor with a small ulcer on the foreskin of his penis. A local excision was performed. Histological examination of the specimen revealed superficial basal cell epithelioma. Basal cell epithelioma is a common tumor of the skin, but is rarely found on the penis. Only 11 cases have been reported in the European and American literature. Basal cell epitheliomas were formerly called basal cell carcinomas and were treated as true carcinomas. However, recently they have been treated as benign tumors because of their good prognosis and rare metastasis.
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With the improvement of recovery ratio of trophoblastic disease by means of primary chemotherapy, undetermined cases of trophoblastic diseases, whose morphological examination has not been conducted, have increased. The respective sickly constitutions of these cases are extremely complicated, and we have deviced a new close classification of these cases from clinical standpoint. For the purpose, we have chosen out the following items.: A. Major subdivision 1. Types of antecident pregnancy. 2. Duration between the antecident pregnancy and the commencement of chemotherapy. 3. Urinary hCG secretion pattern following molar pregnancy. 4. Following treatment of hydatidiform mole. B. Minor subdivision 1. Urinary hCG titer at the commencement of chemotherapy. 2. BBT pattern. 3. Chest x-ray findings. 4. PAG. 5. Clinical signs. 6. Development of focuses (clinical). 7. Necessary reasons for chemotherapy. These items are expressed respectively by figures. This close classification method is based on the combinations of these figures. The authors believe, this method will enable the easy classification of early chemotherapy examples and will present a strong key for the analysis of enormous cases.
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An isotachophoretic method was developed for the determination of EDTA in foods imported by Japan. Skimmed samples of dressings, mayonnaise, or margarine were chromatographed on an anion exchange column, and interfering organic acids were eluted with water and 0.01N HCl. EDTA was eluted with 0.2N HCl and reacted with ferric chloride to form a stable EDTA--Fe complex. Electrophoresis was carried out with dilute HCl containing 0.05% Triton and beta-alanine (pH 3.5) as the leading electrolyte and 0.01M caproic acid as terminating electrolyte. Since uncoupled EDTA showed more than one zone, it was reacted with ferric chloride to form EDTA-Fe complex which showed only a single zone on an isotachopherogram. More than 90% of EDTA spiked at 100 or 1000 ppm level as disodium salt was recovered from the above mentioned three types of food. Detection limit was 10 ppm as disodium EDTA.
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Tertiary-butylhydroquinone (TBHQ) is extracted from foods with ethyl acetate, the solvent is evaporated, the residue is dissolved in n-hexane-ethyl acetate (99 + 1), and the TBHQ is selectively transferred into an aqueous layer (2% sodium chloride) as a separation from food interferences. Finally, TBHQ is reextracted with n-hexane-ethyl acetate (1 + 1), concentrated, and determined by flame ionization gas-liquid chrmoatography. Dried fish, frozen shrimp, vegetable oils, and edible fats were analyzed by the method. More than 85% was recovered when the samples were fortified with 100 ppm TBHQ. Detection limit was 1.0 ppm TBHQ.
Borate was directly chelate-extracted from foods with 5% 2-ethyl-1,3-hexanediol (EHD) in n-hexane-n-butyl acetate mixture (8 + 2), from which borate was selectively transferred into 1% NaOH, since EHD-chelated boron did not react with curcumin to develop color. Finally, an aliquot of the alkaline solution was acidified with HCl and reacted with curcumin in a rotary evaporator. Color development was increased by heating for 8 min at 80 degrees C under reduced pressure of 16 mm Hg. Frozen shrimp and prawns (peeled and with shells) and salted jelly fish were analyzed by the proposed method. Results were compared with the contemporary official method of Japan based on curcumin reaction on an incinerated sample. Over 90% of the boric acid was recovered by the proposed method when samples were fortified with 20 ppm boric acid. Recoveries were superior to those of the official method especially for shrimp and prawns with shells and salted jelly fish. Detection limit of boric acid is 1 ppm. Moreover, the method requires only about 1 hr for analysis of one sample, making it suitable for routine analysis.
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