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Biomedical subjects

M Toussaint

Publications and source records attributed to M Toussaint.

At least 91 records · Page 5Linked to original sources
PubMed1982

[Congenital cardiopathies in adults. 179 cases].

Congenital heart disease in the adult represents less than 25 p. 100 of all congenital heart diseases; 179 out of 800 cases in the authors' experience. Atrial septal defect (ASD) is by far the most common (44 cases) especially in adults over 40 years of age. Practically all large ASD develop complications and systematic repair is recommended in all age groups except in forms with severe pulmonary hypertension and high pulmonary arteriolar resistance. Ventricular septal defect (VSD) is almost as common. They are usually small and only rarely present after 40 years of age, suggesting that spontaneous closure may occur even after 20 years of age. Coarctation of the aorta should be operated on before adulthood as persistant hypertension becomes more common in patients operated later. Eisenmenger's syndrome, the inevitable conclusion of VSD with severe hypertension not operated during childhood, or of some large ASDs in adults is often well tolerated and may survive until an advanced age. Survival of Fallot's tetralogy is very rare after 20 years without surgery; complete repair should therefore be performed early despite its drawbacks. Thus, unoperated congenital heart diseases should no longer be observed in adults excepting minor forms which do not justify the operative risks, and complicated forms for which no surgical cure is yet available.

Adult↗
PubMed1981

[Ultrastructural alterations of the alveolar walls capillaries by injection of histamine (author's transl)].

Histamine chlorhydrate was intravenously injected to Guinea pigs (7 microgram/kg). Alterations of the alveolar walls capillaries were by electronic microscopy studied 1.5, 12 and 15 minutes after injection. It was observed a rapid dilator effect associated with an opening of the endothelial cells tight junctions, an increasing in the size and turnover of pinocytic vesicles, an enlargement and a loss of homogeneity of the basal membrane and an edema of type I pneumocytes. In the last group of animals, lesions reversibility is characterized by a beginning of closing of endothelial cells junctions and of edema resorption. These morphological findings point out the local effect of histamine on the pulmonary capillary microcirculation and show the decrease of resistance and the increase of permeability of the capillaries.

Animals↗
PubMed1979

A double-blind study of erbium169 synoviorthesis in rheumatoid digital joints. Results after one year.

A double-blind study was made on the effectivenss of erbium169 synoviorthesis in the digital joints of 7 patients with erosive, seropositive rheumatoid arthritis. The study involved 70 joints observed over a 12-month period: 20 pairs of metacarpophalangeal joints (MCP) and 15 pairs of proximal interphalangeal joints (PIP) were injected with erbium169 in one joint and saline in the other one. All joints had radiological lesions corresponding to State I and II of the Steinbroker classification. Six months after synoviorthesis, good and excellent results were observed in 71% of the articulations treated with erbium169 and in only 40% of those injected with saline (placebo) (p less than 0.01). Good and excellent results were noted in 79% of the joints treated with the isotope after one year, compared with only 50% injected with the placebo (p less than 0.05). The beneficial effect of erbium169 synoviorthesis on the pain and inflammatory phenomena of rheumatoid digital joints is therefore proven. Occasionally the isotope causes a slight decrease in the range of movement of the treated joint.

Arthritis, Rheumatoid↗
PubMed1977

[Interventricular communication, aneurysm of the membranous septum and acquired atrioventricular block].

Over a ten year period of a man 40 had a progressively increasing atrioventricular conduction defect, resulting from a ventricular septal defect with eventual cardlac failure due to persistant bradycardia. Intracavitary recordings showed the block to be situated distally, below the bundle of His. Cineaarteriography, and subsequent operation, showed an aneurysm of the membranous septum lying above a fibrous-edged ventricular septal defect. The aetiology of the block is discussed in the light of these defects; Haemodynamic trauma to the conduction pathways exposed in the inferior edge of the septal defect seems to be the most likely cause.

Adult↗
PubMed1977

[Hypoplasia of the right ventricle with inter-atrial communication and without any other abnormality. Apropos of a case treated surgically by closure of the inter-atrial communication].

A case is reported of hypoplasie of the right ventricle with a wide atrial septal defect in a child of 10. The presence of cyanosis with right atrial and left ventricular preponderance led us to suspect tricuspid atresia, but this was excluded by catheterisation and angiocardiography. There was definitely and atrial septal defect with a two-directional shunt, but the tricuspid valve could be negotiated, and the right-sided opacity provided the essential diagnostic criterion, namely hypoplasia of the sinus portion of the right ventricle with a normal infundibulum. 17 other published cases of hypoplasia of the right ventricle with atrial septal defect are reviewed. The current indications for surgery are discussed in the light of the nature of the disordered physiology. Simple closure of the atrial septal defect, which was carried out successfully in 3 cases, appears to be of great value in the larger child, when there is a wide defect.

Angiocardiography↗
PubMed1976

[Toxic reactions to gold salts with severe enterocolitis in a patient with rheumatoid arthritis].

A case of severe enterocolitis which occurred on initiation of chrysotherapy for rheumatoid arthritis is reported. The patient, a male aged 50 years, suffered from dramatic diarrhea for several weeks. Biopsy specimens from the stomach, ileum and colon revealed signs of inflammation. Later, general toxicodermia, mouth ulcers, blood eosinophilia and asymptomatic proteinuria were observed. After several months all the side effects disappeared. The toxicodermia was the most persistent.

Arthritis, Rheumatoid↗