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Biomedical subjects

M Tost

Publications and source records attributed to M Tost.

17 recordsLinked to original sources

[Diagnosis and therapy of chronic canaliculitis].

The chronic lacrimal canaliculitis is often overlooked and unsatisfactory treated. The purpose of this long-term study (1978-1991) is to call attention to special bacteriological signs and to give recommendations for proper treatment. 54 patients (39 females and 15 males) in age from 29 to 85 years (average age of 60 years) with a chronic lacrimal canaliculitis were evaluated. "Sulfur granules" were obtained from 32 patients and 54 specimens were collected from 44 patients and processed immediately for aerobic and anaerobic cultivation as well as microscopic investigation. Altogether 100 bacteria could be isolated: 56 anaerobes, 38 aerobes as well as 6 microaerophilic and capnophilic strains, respectively. Members of the genus Actinomyces were the most often isolated anaerobes. They could be detected in specimens of 15 patients by culture and in materials of 4 patients only by microscopic study. 42 from 50 patients were permanently cured by immediate treatment according to our operative procedure despite the splitted canaliculus. The most common cause of chronic lacrimal canaliculitis is a mixed infection. Despite the characteristic clinical symptoms the laboratory evaluation should be done to provide the diagnosis. The surgical procedure leads to a permanent functional healing in a high degree.

Adult

[The antiphlogistic effect of the ginkgolide BN 52 021 in the chemically burned rabbit eye].

BN 52 021, a specific antagonist of PAF receptors, was tested in the early-phase treatment of chemically burned eyes in 30 rabbits. The local application of BN 52 021 eyedrops-1% (water-soluble preparation, 5 times daily, in comparison with the other eye as a control) led to a visible anti-inflammatory effect (microscopically and macroscopically) of the chemically burned anterior eye segment. There was only a moderate increase of the concentration of PGF2 alpha after the chemical burn. The use of specific PAF antagonists seems to have a real chance for treatment of inflammatory reactions of the anterior eye segment. A combination with other mediator antagonists should be tested in further experiments.

Animals

[Normogenesis of the cornea and its modification by cyclophosphamide in the animal experiment].

Animal experiments serving as models have hitherto been indispensable in order to explain pathogenetic processes in the development of malformations. The results presented here are contribution to studies on the normogenesis of the cornea in defined animal material (albino mice of Agnes Bluhm Jena-Halle stock). A single application of cyclophosphamide during embryogenesis caused inhibition malformations. Of these, different degrees of corneal hypoplasia and Peters' malformation are discussed in detail.

Abnormalities, Drug-Induced

[Peter's anomaly in animal experiments].

Histopathological examinations were performed in 193 embryos of mice; Peters's anomaly was found in 2 cases. The authors discuss various theories of formation of this developmental defect and oppose them their own formulation.

Abnormalities, Drug-Induced

[Measurement of the power of artificial intraocular lenses].

Fifty five anterior chamber artificial lenses of the Hellgrebe model 2(35) and Fiodorov's (20) were verified from the angle of the power quoted by the producer. The measurement of the length of the frontal power were performed by means of a measurer 70 (Carl Zeiss, Jena, GDR) and by a specially designed plastic cuvette suitable for sterilization. The mean deviation amounted -1.42 dptr. for the Hellgrebe's 2 lens and 0.23 dptr. for Fiodorov's lens. The Hellgrebe type 2 lenses do not answer the international quality norms of tolerance +/- 0.25 dptr.

Anterior Chamber

[Prognosis of basal cell carcinoma of the eyelids in relation to histologic differentiation and thoroughness of resection].

As life expectancy increases the diagnosis and treatment of basal cell carcinoma of the lids is assuming ever greater importance. While there is still some debate as to whether conservative or surgical treatment is preferable, the emphasis in conservative treatment varies. Our own view is based on an analysis of 531 surgically treated patients. For histologic differentiation we used the data of Lever (1958). Considering that our recidivity rate was only 6.2%, we recommend primary surgical treatment. After localization of the tumor the inner canthus in particular should be kept under observation for recurrences. Histologic differentiation showed the sclerodermiform basal cell carcinoma to be especially dangerous.

Adult

[Enzymatic studies in lenses of different breeds of mice (author's transl)].

Leucinaminopeptidase (LAP), lactatedehydrogenase (LDH) and glucose-6-phosphatdehydrogenase (GPDH) were analysed in the lenses of two different breeds of mice. Compared to the lenses of a control stock (Agnes Blum, Jena), in the healthy seeming, heterozygous mice the same activities of LAP, LDH, and GPDH were found. But in the breed with evident microphthalmos and cataract LDH was increased. Possible connections are discused.

Animals

Leukotriene antagonist S 872419 A for early-phase treatment of chemical burn in the rabbit eye.

S 872419 A, a specific receptor antagonist of peptide leukotrienes, was tested in the early-phase treatment of chemically burned eye (0.25 mol/l sodium hydroxide) of the rabbit. The drug was topically applied 5 times a day in a 1% solution, controls were the untreated opposite eye. Gross and microscopic investigations indicated that S 872419 A inhibits the inflammatory response of the chemically burned anterior eye segment. The parameters of healing considered (epithelial regeneration, corneal clouding and swelling, infiltration with polymorphonuclear leukocytes) suggest inhibition of lipoxygenase-mediated reactions in the tissue. PGF2 alpha levels were the same in aqueous humour of treated and untreated eyes. Further experiments with S 872419 A and other nonsteroidal drugs should improve the anti-inflammatory therapy of the chemically burned eye.

Animals