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Biomedical subjects

M Tonato

Publications and source records attributed to M Tonato.

131 records · Page 8Linked to original sources
PubMedDate not supplied

Metastatic spindle cell carcinoma: a complete response induced by cisplatin and 5-fluorouracil.

A patient with biopsy-proven spindle cell carcinoma, of unknown primary site, metastatic to the neck and to the lung, was treated with chemotherapy consisting of cisplatin (20 mg/m2/day) on days 1-5 and 5-fluorouracil (1000 mg/m2/day) on days 1-5. The regimen was repeated every 28 days. The patient had a complete response confirmed by computerized tomography. The patient is in a disease-free status 12 months after diagnosis. Toxicity was mild. To our knowledge, this case represents the first chemotherapy induced complete response documented in this rare entity.

Adult↗
PubMedDate not supplied

Italian clinical experience from the major co-operative groups in small cell lung cancer.

The clinical experience of Italian co-operative groups started in the early 1980s with the first randomised studies on alternating non-cross resistant combination chemotherapy carried out by the Italian Oncology Group for Clinical Research (G.O.I.R.C.) and by the Umbria Lung Cancer Study Group. Later, most of the investigators moved their interest to exploring the clinical relevance of increased dose intensity in the treatment of small cell lung cancer (SCLC). Several trials have been completed and published from Padova, Perugia, Genova and the Oncology Co-operative Group South Italy (G.O.C.S.I.). At the same time, another issue which arose in clinical research of SCLC was the late intensification of treatment after induction chemotherapy. Two ongoing phase II trials were designed at the Milan National Cancer Institute and at the Department of Medical Oncology, in Perugia and Rome. Finally, G.O.C.S.I. and a large Italian co-operative group are evaluating the integration of different modalities of treatment, mainly exploring the role of surgery in the management of limited SCLC.

Antineoplastic Combined Chemotherapy Protocols↗
PubMedDate not supplied

A double-blind study comparing two single-dose regimens of ketorolac with diclofenac in pain due to cancer.

STUDY OBJECTIVE: To compare the analgesic efficacy and safety of two single doses of ketorolac with diclofenac in acute cancer pain. DESIGN: Double-blind, randomized, clinical study. SETTING: Hospital-based clinical research center. SUBJECTS: One hundred eighty patients suffering acute, moderate, or severe cancer pain. INTERVENTIONS: A single intramuscular injection of ketorolac 10 or 30 mg or diclofenac 75 mg. MEASUREMENTS AND MAIN RESULTS: Pain intensity was assessed 30 minutes and 1, 2, 3, 4, 5, and 6 hours after injection or until rescue drug administration. In approximately 70% of patients all treatments provided prompt sustained pain relief throughout the 6-hour observation period. There were no statistically significant differences in any of the analyzed efficacy measures among the three groups. CONCLUSION: Intramuscular ketorolac 10 mg is adequate to relieve cancer pain, and is equivalent to ketorolac 30 mg and to diclofenac 75 mg.

Aged↗