The public stake in medical research.
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Drug Industry↗
Biomedical subjects
M Tishler
Publications and source records attributed to M Tishler.
Drug research--whence and whither.
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Pharmaceutical Preparations↗
Drug discovery-background and foreground.
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Chemical Phenomena↗
Pulmonary changes in angioimmunoblastic lymphadenopathy as demonstrated by computerized tomography.
A case of angioimmunoblastic lymphadenopathy with pulmonary involvement is presented. The radiographic and computerized tomographic findings included multiple opacities, predominantly basal, of variable size. Associated pleural opacification was verified on both the chest roentgenogram and the computerized tomographic (CT) examination. The entity may mimic many more common clinical disease states and final diagnosis can only be established histologically.
Aged↗
Abdominal fat tissue aspirate in amyloidosis of familial Mediterranean fever.
Abdominal fat tissue aspirates from 20 patients with biopsy-proved amyloidosis were investigated by polarized microscopy after staining with Congo-red. Positive results were obtained in 4 of 5 patients with primary amyloidosis (AL) and in none of 15 with amyloidosis (AA) of Familial Mediterranean Fever (FMF). We suggest that although this technique is simple, safe and effective in other forms of amyloidosis, it cannot be used as a diagnostic tool in FMF patients suffering from amyloidosis.
Abdomen↗
Federal support of research in the health sciences.
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Government↗
Primary Sjögren's syndrome and primary biliary cirrhosis: differences and similarities in the autoantibody profile.
Sera from 61 patients with primary biliary cirrhosis (PBC) and 23 patients with primary Sjögren's syndrome (pSS) were tested for the presence of autoantibodies to 15 different antigens (PDH, RNP, SS-A, SS-B, Sm, Scl-70, H2AH2B, Jo-1, collagen-type I, GBM, GM <--> 1, Sulf, GD1b, MPO, PR3). Patients with pSS had significantly (p < 0.01) higher frequencies of antibodies to SS-A, SS-B and RNP (78%, 52%, 22% vs 29%, 20%, 5%, respectively) when compared to patients with PBC. On the other hand, patients with PBC had significantly (p < 0.01) higher frequencies of antibodies to PDH, Sm, Jo-1, collagen and MPO (80%, 34%, 26%, 52%, 67% vs 13%, 9%, 13%, 13%, 9%, respectively) as compared with patients with pSS. For all the other autoantibodies, no significant differences were found between PBS and pSS patients. These data on the similarities in autoimmunity between two diseases with different clinical presentations shed more light on the mosaic of autoimmunity.
Adult↗
Epileptic seizures as a neurological complication of Reiter's syndrome.
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Adult↗
Jaccoud's arthropathy and psoriatic arthritis.
A patient with long-standing psoriatic arthritis developed an arthropathy of the hands characterized by subluxations of the metacarpophalangeal joints without erosive changes. This is to the best of our knowledge the first reported case describing Jaccoud's arthropathy associated with psoriatic arthritis.
Arthritis, Psoriatic↗
Sleep disturbances, fibromyalgia and primary Sjögren's syndrome.
OBJECTIVE: To investigate the association and prevalence of sleep disturbances and fibromyalgia (FM) in a group of patients with primary Sjögren's syndrome (pSS). METHODS: Sixty-five patients with pSS were investigated. A 10-point Mini Sleep Questionnaire (MSQ) was completed focusing on sleep complaints. The same questionnaire was also used in three control groups: Group A-67 patients with rheumatoid arthritis. Group B-53 patients with rheumatoid arthritis (RA) and sicca symptoms; Group C-31 patients with osteoarthritis. All patients with pSS were also studied fro the presence of FM. RESULTS: Moderate or severe sleep disturbances were reported by 49 out of 65 pSS patients (75%). This frequency was significantly higher than that reported by patients in the three control groups (p < 0.001). FM was present in 36 out of 65 pSS patients (55%) and was associated with sleep disturbances. FM or sleep disturbances were not associated with any clinical or laboratory parameters. CONCLUSION: Our results suggest that sleep abnormalities and FM in pSS patients are frequent and their etiology might involve other mechanisms besides joint pain or sicca symptomatology.
Aged↗