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Biomedical subjects

M Thiery

Publications and source records attributed to M Thiery.

At least 325 records · Page 18Linked to original sources
PubMedDate not supplied

Development of a miniature, low-dose, frameless intrauterine levonorgestrel-releasing system for contraception and treatment: a review of initial clinical experience.

A low-dose levonorgestrel (LNG)-releasing intrauterine system (IUS) (FibroPlant) has been clinically developed since 1997 for endometrial suppression during hormone replacement therapy in peri- and postmenopausal women, for the treatment of menorrhagia in women with normal uteri or with uterine fibroids, for contraception, for the treatment of endometrial hyperplasia, and for alleviating primary and secondary dysmenorrhoea. Results of preliminary studies confirm the promising nature of this all-round drug delivery system. The low dose of LNG released accounts for the low hormonal side-effect rate and virtual absence of amenorrhoea in premenopausal women. The system has not yet been evaluated in tamoxifen users (to protect the endometrium), or in women with rectovaginal endometriosis. However, early indications suggest that the system will also be suitable for these indications. The frameless drug delivery support of this LNG-releasing IUS has been optimized to reduce the size of the foreign body and to maximize tolerance and continuation of use while simultaneously providing for the maximum duration of action.

Contraception↗
PubMedDate not supplied

[Histoenzymologic modifications of placental tissue in experimental fetal hypotrophy in the rat].

Chronic placental vascular insufficiency in the rat was achieved by ligature of the uterine and utero-placental arteries. The fetal and placental hypotrophy observed confirmed the previous observation. However, the placental enzymatic changes showed an increasing gradient of cellular hypoxy from decidua basalis to yolk sac placenta; this gradient is unfavourable to fetuses. The strong depletion of yolk sac enzyme activities demonstrates the reduction of fetomaternal exchanges which are usually predominant in this placental area. The other parts of rat placenta appear relatively less involved in fetal nutrition. Further studies are necessary to understand the changes observed in these activity stainings, such as: oxidoreductases II, acid phosphatase and 5-nucleotidase.

Aminopeptidases↗
PubMedDate not supplied

Fetal Doppler flow measurements in the early second trimester: a correlation with fetal outcome.

In 31 women with a singleton pregnancy, abdominal duplex doppler examinations were performed at W16-W17, W26 (+/- 2 weeks) and W34 (+/- 2 weeks) in order to study the flow velocity wave (FVW) indices in the early second trimester and their predictive value for fetal outcome. 24 women with a normal pregnancy outcome were considered as the reference group. In the early second trimester, end-diastolic block occurs frequently at the 150 Hz thump filter setting (15/24 in the fetal descending aorta, 19/24 in the umbilical artery). At the 50 Hz filter setting, end diastolic block appeared in 1/24 cases in the aorta and in 2/24 cases in the umbilical artery. The finding did not persist throughout pregnancy. The flow-velocity indices in the early second trimester in the small-for-dates were comparable to the normal group. We conclude that high peripheral resistance is a common finding in the fetal circulation in early pregnancy. It is not predictive of subsequent growth retardation.

Aorta↗
PubMedDate not supplied

Preterm labor: the role of amnionitis.

This prospective study represents an attempt to find a link between subclinical intra-amniotic infection and preterm singleton labor in 27 asymptomatic patients with intact membranes. Liquor amnii was obtained by transabdominal amniocentesis and cultured for anaerobic and aerobic bacteria and mycoplasmas. None of these cultures was positive. The value of gas-liquid chromatographic determination of volatile and non-volatile acids in liquor amnii could not be determined because amniotic infections did not occur in the population under study.

Amniocentesis↗
PubMedDate not supplied

Capping placenta. A new etiologic factor in midtrimester bleeding.

The results of an echographic study to determine the causal factors in 63 consecutive cases of second-trimester bleeding are presented. True second-trimester bleeding is uncommon (0.8% of pregnancies during the study period), but the impact on fetal outcome is serious because the condition is associated with late abortion, preterm intra-uterine demise, preterm birth, and neurologic sequelae. Various placental structural anomalies occurred in 8% of our cases, and another 8% showed marginal solution of the placenta. In 6% there was retro-amniotic bleeding, whereas placenta praevia was seen in only 3%. The prevailing placental localization (27%) found in patients with second-trimester hemorrhage was a peculiar one in that the placenta literally "capped" the lateral as well as the anterior and posterior walls of the uterine cavity, while the lower margin failed to reach the isthmic region. This type of placentation, which we call capping placenta, occurs in only 2.6% of normal pregnancies. The implication of the findings are discussed.

Congenital Abnormalities↗