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Biomedical subjects

M Thiery

Publications and source records attributed to M Thiery.

At least 181 records · Page 10Linked to original sources
PubMed1981

Extra-amniotic prostaglandin E2 gel vs. amniotomy for elective induction of labour.

A randomized study was performed to compare three methods of labour induction in 143 clinically normal women (43 nulliparas) at term: amniotomy with or without intravenous oxytocin, extra-amniotic prostaglandin (PG) E2 gel, and extra-amniotic PGE2 gel plus an indwelling catheter. The three methods appeared to be comparable in effect and all of them were perinatally safe. Thus, if preference is given to keeping the ovular sac intact during the early phase of induced labour, extra-amniotic PGE2 in viscous gel, either with or without an indwelling catheter,. can replace the classical induction technique.

Amnion↗
PubMed1980

Randomized trial of two beta-mimetic drugs (ritodrine and fenoterol) in acute intra-partum tocolysis.

The uterine inhibitory effect and potential maternal and fetal side effects of two beta-mimetic compounds, ritodrine hydrochloride and fenoterol hydrobromide, were compared in a randomized trial. The drugs were administered by intravenous infusion to 24 healthy term nulliparous women during effective first-stage labour; each of them received fenoterol (1, 2, or 4 microgram/min) or ritodrine (100, 200, or 400 microgram/min). There was no difference between the drugs in the intensity of the uterine inhibition. However, for a similar inhibitory effect, the duration of tocolysis was longer after ritodrine. During the intrapartum and neonatal periods, neither compound induced any change in the fetal parameters investigated, and their effects on maternal parameters were comparable.

Blood Pressure↗
PubMed1980

Fetal heart rate pattern before, during and after amniotomy.

This prospective study concerned the immediate possible effects of low amniotomy on the fetal heart rate pattern of 32 normal term subjects. Artificial membrane rupture was performed early in labour in 16 gravidas and to induce labor in the others. In only 1 fetus was no specific alteration of the heart rate pattern recorded. The type and incidence of fetal heart rate pattern alterations observed during and within 1 h after low amniotomy were comparable in laboring and induced gravidas. The most frequently observed patterns were short-lived FHR acceleration and increased band-width. Short-lived bradycardia was recorded in only 4 patients after amniotomy. The majority of the alterations observed were not indicative of fetal distress as a direct result of artificial membrane rupture.

Female↗
PubMed1980

Termination of pregnancy by intramuscular administration of 15 (S)-15-methyl-prostaglandin in F2 alpha.

The use of 15 (S)-15-methyl-prostaglandin F2 alpha for second-trimester termination of pregnancy, induction of labor in the presence of a dead or severely malformed fetus, and the management of molar pregnancy was investigated in 212 women. The dosage regime was 250 microgram of the prostaglandin analogue every 1 to 3 hours. Cumulative expulsion rates amounted to 94 and 97% after 24 to 36 hours, respectively. Gastrointestinal side effects occurred in 48% of the patients, and both the number and intensity of the episodes were significantly reduced by antiemetic and antidiarrheal drugs. No serious complications occurred.

Abortion, Induced↗
PubMed1980

Cardiotoxicity of ritodrine: assessment based on serum creatine kinase activity.

Thirty-three gravidas undergoing chronic tocolysis with ritodrine were assessed with respect to potential drug-induced cardiotoxic effects. The immunological and electrophoretic determination of serum creatine kinase activity gave no indication of such effects. The results of this study confirm the significant increase reported for the serum activity of the MB, BB, and MM creatine kinase isoenzymes during the post-partum period. In most cases no difference was found between the isoenzyme distribution pattern characterizing acute myocardial infarction and normal labor, and therefore the measurement of serum creatine kinase activity during labor has no value for the diagnosis of acute myocardial infarction.

Creatine Kinase↗