Biomedical subjects

M Thelen

Publications and source records attributed to M Thelen.

At least 451 records · Page 25Linked to original sources

PubMed1975

[Catheter embolisation of the splenic artery as treatment for acute bleeding from varices (author's transl)].

Embolisation of the splenic artery with fibrin foam, in order to stop acute bleeding from varices, was carried out in two patients. This was performed immediately after diagnostic arterial indirect demonstration of the portal vein; by this method it is possible to achieve at least a temporary cessation of bleeding from oesophageal or gastric varices. The procedure is indicated in desparate situations, if intubation has been unsuccessful or has had to be discontinued, when endoscopic sclerosis is contra-indicated or when an emergency shunt cannot be carried out because of poor liver function or the general condition of the patient. Permanent results cannot be expected and recurrence of bleeding cannot be avoided. The use of splenic embolisation depends on stopping the acute bleeding in order to obtain an interval during which liver function can be improved so that a decompressing shunt operation becomes possible subsequently.

Acute Disease↗

PubMed1975

[The diagnosis of carcinoma of the breast in relation to growth rate (author's transl)].

The doubling time (DT) was estimated quantitatively for 16 carcinomas of the breast according to the method described by Collins and co-workers in 1956. This is based on the concept of constant and exponential growth. Observation interval for these mammographically confirmed tumors was between 83 and 1,034 days. The DT was calculated to vary from 45 to 260 days; in order to reach a diameter of 1 cm. after 30 divisions would require a period of 3.7 to 21.4 years. Mammography frequently demonstrates small, clinically occult, tumours. Axillary lymph node metastases are relatively rare from small tumours; growth rate of 70% of breast carcinomas in such that an annual clinical and radiological check-up will prove to be the best means of reducing mortality from carcinoma of the breast. The risk inherent in the radiation resulting from annual mammography is acceptable in women over 35 years. This leaves the problem of rapidly growing carcinomas which would escape early diagnosis by early examinations. Half-yearly examinations of women in high risk groups (1. Previous mastectomy for carcinoma, 2. Biopsy-proven mastopathy with atypical proliferation) comprising about 30% of carcinomas with a short doubling time would appear to be reasonable.

Adenocarcinoma↗

PubMed1975

[Laevo-cardiography for estimating the function of the left ventricle. II Mitral insufficiency].

1. The normal left ventricle is characterised by the relationship between end-diastolic volume and ejection fraction. (Reduction in the lateral projectional area by 50--60% during systole, as compared with the end-diastolic projectional area.)--2. The functionally sufficient left ventricle in the presence of haemodynamically significant mitral insufficiency shows and increasing end-diastolic measurement with increasing volume.--3. End-diastolic projectional area, up to 85 cm.2, and end-diastolic filling pressure, up to 20 mHg are associated, apart from odd exceptions, with normal contraction indeces, i.e. a normal ejection fraction. --4. Within these magnitudes of area and pressure, there is a demonstrable relationship between area/pressure quotient and contracture index. --5. Insufficiency of muscular contraction of the left ventricle in mitral insufficiency is characterised, with reduced normal or enlarged, end-diastolic areas and normal, or increased, end-diastolic filling pressure by an abnormal relationship between ejection fraction and end-diastolic volume (contraction index less than 50%). --6. In mitral insufficiency which is haemodynamically significant, some of the residual blood may be used as a supplement for ventricular filling.

Angiocardiography↗

PubMed1975

[Coronary fistula into the sinus coronarius. Hemodynamics, clinical aspects, therapy].

Coronary artery fistulas are rare, inborn anomalies which will be diagnosed more often as the diagnostic method of coronary arteriography is increasing. This report concerns a preoperatively diagnosed coronary arteriovenous fistula of the right coronary artery to the sinus coronarius; Frequency, pathological physiology, clinical symptoms, differential diagnosis, prognosis and treatment are discussed. The importance of using selective coronary arteriography to outline the anatomy of these malformations is stressed. Surgical treatment is the only effective way of therapy and should be performed after diagnosis, even if in an early stage of the disease the ECG does not show any changes in spite of a large fistula.

Adult↗

PubMed1974