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Biomedical subjects

M Thakur

Publications and source records attributed to M Thakur.

43 records · Page 3Linked to original sources
PubMed1979

Desferoxamine mesylate (Desferal): a contrast-enhancing agent for gallium-37 imaging.

Desferal (desferoxamine mesylate) was investigated as a contrast-enhancing agent for tumor and abscess imaging with 67Ga-citrate. Tumor studies were performed in mice with Cloudman S-91 melanoma. Abscess studies were performed with a subcutaneous abscess model in rabbits. When Desferal is administered 16 to 18 hours after injection of 67Ga, rapid blood clearance of 67 Ga occurs with only slight (tumor) or no (abscess) loss of activity from the lesion. Retention in other organs is variable. Tumor-to-blood ratios are improved eightfold in tumor and fourfold in abscess in studies performed with single Desferal injections of 150 mg/kg. Blood and total body clearance studies in rabbits reveal that maximum Desferal effect is achieved in the 17 to 50 mg/kg dose range and that only minimal improvement occurs at higher doses.

Abscess↗
PubMedDate not supplied

Mu opiate isoreceptors: differentiation with kappa agonists.

In vivo pharmacological data support the concept of mu (mu) isoreceptors in the rat CNS. The mu 1 receptor mediates analgesia and regulation of cholinergic neurons. Naloxazone may be a specific antagonist of this receptor type. In contrast, the mu 2 receptor is responsible for respiratory depression and regulation of nigrostriatal dopaminergic neurons. In this case, the kappa agonists EKC and MR-2034 appear to be specific mu 2 antagonists.

Acetylcholine↗
PubMedDate not supplied

Cost containment in small hospitals: targeting strategies beyond this decade.

This study identifies the contributors to cost containment in small size, full-service hospitals (100-199 beds). A conceptual model has proposed and tested on data from 316 executives representing both for-profit and not-for-profit hospitals. The data suggest that the for-profit sector is more effective in managing its costs than its not-for-profit counterpart. However, the findings raise the issue of whether cost management leads to cost containment. The assumption of this study is that cost containment is a strategic concern, while cost management is operational.

Cost Control↗