Search PubMed⌕ Search

Biomedical subjects

M Tautz

Publications and source records attributed to M Tautz.

At least 19 recordsLinked to original sources
PubMed1987

Radiopharmacokinetics and radiation dose from 99mTc-HM-PAO (preliminary report).

Whole body retention measurements were performed in volunteers after i.v. injection of 99mTc-HM-PAO (Ceretec). The organ accumulation was measured in mice and data were transferred to standard man according to ICRP. Absorbed dose calculations were made with these data by using the concept of absorbed fractions (MIRD method). In man, the whole body retention and the retention in the brain could be calculated by direct measurement, absorbed doses to the other organs could only be derived from animal data. The absorbed dose to the brain derived from human data (10.3 microGy/MBq) is greater by a factor of 2 than that derived from animal data. The highest absorbed dose was received by the thyroid (24.4 microGy/MBq), the absorbed dose to the ovaries, testes and whole body ranged from 2.8 to 4.2 microGy/MBq.

Animals↗
PubMed1987

Radiopharmacokinetics and radiation absorbed dose calculations from 131I-meta-iodobenzylguanidine (131I-MIBG).

In connection with clinical 131I-MIBG studies of patients with suspected pheochromocytoma and adrenomedullary hyperplasia quantitative biokinetic data have been collected in order to improve the present estimations of absorbed dose to various organs and tissues. Whole-body profiles as a function of time were measured with a whole-body counter. The retention in the total body and in the thyroid gland could be derived from the measured whole-body profiles by summing up the corresponding values. The retention of 131I-MIBG could not be exactly measured for further organs from the whole-body profiles in man. For this reason animal studies were performed with mice. The biokinetic animal data were transferred to man in form of the cumulative activity for the various organs. The mean absorbed dose for selected organs per injected activity unit was calculated using the concept of absorbed fractions (MIRD method) taking into account the radioactivity within the remaining body. Except for both the adrenal medulla and the thyroid gland the absorbed doses for all the other selected organs are in a range from 0.108 mGy MBq-1 for the testes to 0.176 mGy MBq-1 for the lungs. The absorbed dose to the thyroid gland amounts to the considerable value of 5.69 mGy MBq-1 although the thyroid gland was blocked. The greatest absorbed dose was estimated for the normal adrenal medulla with 18.67 mGy MBq-1.

3-Iodobenzylguanidine↗
PubMed1984

Radiation dose and risk of patients through nuclear medical procedures in the GDR. A comparison of 1978 and 1981.

For the years 1978 and 1981 we compared the radiation dose for the patients examined by in vivo methods after administration of radiopharmaceuticals (27 procedures). The somatic effective dose equivalent, the effective collective dose, the somatic radiation risk, and the number of induced malignancies were calculated according to ICRP publication No. 26. All the procedures give rise to a radiation-induced somatic risk from the 4th up the 7th order. In recent years we have seen an increase of the application of 99mTc compounds and a decrease in the use of 131I-sodium iodide. A comparison of the results for the two years shows the expected reduction of radiation dose and risk.

Germany, East↗