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Biomedical subjects

M Taniguchi

Publications and source records attributed to M Taniguchi.

879 records · Page 49Linked to original sources
PubMedDate not supplied

Interstitial pneumonitis after allogeneic bone marrow transplantation following total body irradiation.

The records of 40 patients who received allogeneic bone marrow transplantation (BMT) at Hyogo College of Medicine under the same conditioning regimen using cyclophosphamide and total body irradiation (TBI) from January 1984 to August 1989 were analyzed. The dose rate of TBI was 10 cGy per minute, and the total dose was 10 Gy (2.5 Gy daily for 4 days). Interstitial pneumonitis (IP) occurred in 13 of 40 patients, and was fatal in five patients. The probability of developing IP during the first year was 31%. We performed univariate analysis on the following factors but did not find any significant risk factors for IP: age and sex of patient, sex mismatch, ABO mismatch, grade of acute graft-versus-host disease, post immunosuppression regimen, and number of marrow cells transfused.

Acute Disease↗
PubMedDate not supplied

Osteosarcoma following radiotherapy: a case report.

The case of a patient with postirradiation osteosarcoma is presented. The 20-year-old female was diagnosed as having osteosarcoma by histological examination of an open biopsy specimen. She underwent surgery for pure dysgerminoma and received adjuvant postoperative radiotherapy, 40 Gy to the pelvis and 30 Gy to the para-aortic region, 11 years ago. This case satisfied the criteria for radiation-induced osteosarcoma proposed by Cahan et al. Radiation-induced osteosarcoma is rare, but the possibility of that must be borne in mind.

Adult↗
PubMedDate not supplied

High-dose-rate intraluminal brachytherapy for postoperative residual tumor of gallbladder carcinoma: a case report.

The case of a patient with gallbladder carcinoma who had a postoperative residual tumor treated with high-dose-rate intraluminal brachytherapy (HDRIBT) and external radiotherapy (ERT) is presented. HDRIBT (20 Gy/2 fr) was performed at one point 10 mm from the 60Co source on 27 and 34 days after simple cholecystectomy. ERT (30 Gy/15 fr) was also given two weeks after HDRIBT. Following radiotherapy, she has been alive and well without signs of recurrence for one year and ten months as of this writing. HDRIBT combined with ERT is recommended for the treatment of post-operative residual tumors of advanced gallbladder carcinomas.

Adenocarcinoma↗
PubMedDate not supplied

Aneurysmal bone cyst treated by high-energy, low-dose radiation therapy: a case report.

Aneurysmal bone cysts (ABC) are frequently treated surgically, but recurrence is not uncommon and surgery is hazardous when the lesion is large and adjacent to the growth plate. High-energy, low-dose radiation to an 8-year-old girl with ABC of the distal tibia was found to be successful, with no recurrence during the five-year follow up. No complications have ensued, and excellent function has been sustained. Further evaluation of this radiation treatment is important for similar situations in which surgical excision of ABC may involve high risk.

Bone Cysts↗
PubMedDate not supplied

Primary rectal cancer treated with high-dose-rate intraluminal brachytherapy following external radiotherapy.

An 80-year-old man with rectal cancer who had diabetes and angina was treated with high-dose-rate intraluminal brachytherapy (30 Gy) following external radiotherapy (30 Gy). After this treatment, anal pain and bleeding improved greatly, and he was able to evacuate the bowels. However, the endoscopic biopsy taken five months after treatment revealed active cancer cells.

Adenocarcinoma↗
PubMedDate not supplied

Total lymphoid irradiation and total body irradiation for allogeneic bone marrow transplantation in aplastic anemia.

Between April 1980 and June 1989, 15 patients with severe aplastic anemia (SAA) were treated at Hyogo College of Medicine with bone marrow transplantation (BMT) after preparation consisting of cyclophosphamide (CY) and total lymphoid irradiation (TLI) or total body irradiation (TBI) for the purpose of reducing the incidence of graft rejection. All patients had initial evidence of engraftment after the first transplantation except for one patient who died of heart failure due to CY on the third day after transplantation and could not be evaluated for engraftment. Rejection later occurred in four of these 14 patients, who then underwent successful regrafting. One of these patients, who was conditioned with CY alone at the first grafting, underwent successful regrafting after a conditioning regimen of CY and TBI. In the other three patients, irradiation was performed twice as the conditioning regimen. Thus, 14 of 15 patients underwent successful BMT and are alive with restored hematopoietic function. From the above results, the combination of TLI or TBI and CY was considered to be very useful as a conditioning regimen for BMT in patients with SAA.

Adolescent↗
PubMedDate not supplied

Radiation treatment of superficial spreading carcinoma of the esophagus.

Superficial spreading carcinoma of the esophagus is a relatively rare disease. A 78-year-old man with this lesion was treated with high-dose-rate intracavitary irradiation (6 Gy) following external irradiation (48 Gy). The irradiated length was very long: 21 cm for intracavitary irradiation, which covered almost the entire thoracic esophagus, and 24 cm for external irradiation, which covered the entire thoracic esophagus. After treatment, he was well and could eat solid foods until his death, without tumor, two years and five months after radiotherapy. Intracavitary irradiation with a long irradiation length following external irradiation with a long irradiation length is recommended for the treatment of superficial spreading carcinoma of the esophagus.

Aged↗
PubMedDate not supplied

Esophageal pseudodiverticulum following high-dose-rate intracavitary irradiation for esophageal cancer.

Ninety-two patients with esophageal carcinoma were treated with combination therapy of external irradiation and high-dose-rate intracavitary irradiation. Four of the 92 patients developed esophageal pseudodiverticulum after radiotherapy. Histologically, all four patients showed squamous cell carcinoma before radiotherapy and were locally controlled by the combination therapy. In three of the four cases, pseudodiverticulum was found over one year after radiotherapy. In two of these three cases, pseudodiverticulum correlated with balloon dilatation performed for benign stricture. The pseudodiverticulum of the other case was found at the end of radiotherapy and was thought to be a traction diverticulum. None of the four patients developed a fistula. As of this writing, one of them has been alive and well for 50 months since the initiation of radio-therapy. Two of the other three died due to metastasis 18 months and 27 months later. The last one died due to intercurrent disease 39 months later.

Aged↗
PubMedDate not supplied

Esophageal fistula: demonstration by CT.

While barium esophagography is useful in revealing fistulas between the esophagus and trachea or bronchus, it is not adequate to show those between esophagus and lung or mediastinum. In this study, a patient with esophago-pulmonary and esophago-mediastinal fistulas was evaluated by CT, which proved to be more effective in showing fistulas between the esophagus and lung or mediastinum.

Aged↗