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M Talbot

Publications and source records attributed to M Talbot.

49 records · Page 3Linked to original sources
PubMed1984

[Value of immunohistochemistry in the study of medullary cancer of the thyroid. Implications of the results for the concept of the APUD system and of apudomas].

Immunohistochemical studies in medullary thyroid carcinoma demonstrate the presence of C cells secreting calcitonin but also of other cells secreting other peptides or proteins. These different cells exist in the tumor as well as in metastases. These results and other reported in the literature suggest a common ultimobranchial and endodermal origin for these cells.

APUD Cells↗
PubMed1984

[Immunohistochemical and ultrastructural studies of thyroid cancer].

The results of immunohistochemical and ultrastructural studies have improved our understanding and provide a better method of classifying thyroid carcinoma. These techniques have also enabled identification of tumours with composite cell populations. These tumours pose clinical, diagnostic and therapeutic problems, and pose fundamental questions such as the relationship between vesicular and C cells. In addition, these techniques are the only available method of determining in situ within the tumour tissue the exact location of different antigens. This information may contribute to the study of the function of the molecules in question and of their accessibility to antibodies in vitro or in vivo.

Fluorescent Antibody Technique↗
PubMed1983

[Collagen gel culture of human thyroid cancers].

When seeded on collagen gel surface, human thyroid cells from normal tissue or carcinoma form a monolayer. When the isolated cells are embedded inside the collagen gel, they reorganize into three-dimensional structures. The cells isolated from normal tissue, adenoma, or well-differentiated follicular carcinoma show the typical arrangement of follicular thyroid cells: the apical poles, characterized by microvilli, are oriented towards the follicular lumen; intercellular junctions are present. In contrast, in the papillary and moderately-differentiated follicular carcinomas, the cells are hardly ever associated, and ultrastructural nuclear anomalies are often observed.

Adenoma↗
PubMed1981

[Demonstration in a thyroid cancer of vesicular structures similar to ultimobranchial-type vesicles described in mice].

An immunohistochemical and electron microscopy study has allowed us to find in a human thyroid cancer, follicle differentiation associating in a characteristic architectural pattern C cells, ciliated cells and follicular cells. Ultrastructural features were similar to those described in the normal adult Mouse thyroid by Wetzel and Wollman [1] and interpreted by them as a second type of thyroid follicle of ultimobranchial origin. The discovery of these structures within metastatic lymph nodes excludes normal thyroid follicle contamination. The presence of these neoplastic structures lead us to make the hypothesis of a stem cell of ultimobranchial and endodermal origin common to all the cells described.

Animals↗
PubMed1980

Nasopharyngeal carcinoma in Alaskan Eskimos Indians, and Aleuts: a review of cases and study of Epstein-Barr virus, HLA, and environmental risk factors.

The records of thirty-one patients with nasopharyngeal carcinoma (NPC) diagnosed from 1966 through 1976 among the Alaskan native population (Eskimo, Aleut, Indian) were reviewed. There were 25 males and six females, which results in relatively high incidence rates per 100,000 of 13.5 for males and 3.7 for females. Clinical and pathologic features were similar to those found among southern Chinese NPC patients. Five-year survival rate was 48%. Antibodies to Epstein-Barr virus were higher in NPC patients than in patients with other tumors or matched controls. On histocompatibility testing Sin-2 was not detected, nor was there significantly increased frequency of A2. Instead, BW40 and a second locus blank occurred more often among NPC patients than among other groups. In response to a questionnaire, NPC patients more often reported use of salt fish in the childhood diet, smoking of cigarettes, and exposure to noxious inhalants than did controls, but the differences were not statistically significant.

Adult↗
PubMed1967

Edouard Seguin.

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Education of Persons with Intellectual Disabilitie↗