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Biomedical subjects

M Takimoto

Publications and source records attributed to M Takimoto.

160 records · Page 9Linked to original sources
PubMed1976

Pharmacokinetic model for serum concentrations of ampicillin in the newborn infant.

The time course of ampicillin concentrations in the sera of three newborn infants during and upon termination of intravenous infusion at a constant rate can be described by a two-compartment pharmacokinetic model. The parameters of the model were determined by simultaneously fitting the serum concentration data obtained during and after the infusion by means of a nonlinear regression program with the aid of a digital computer. The half-life of ampicillin in the infants ranged from 2.1 to 2.9 hr; these values are more than twice those observed in adults with normal renal function.

Ampicillin↗
PubMedDate not supplied

Role of hydrogen peroxide in antitumor activity induction by sodium 5,6-benzylidene-L-ascorbate.

Role of hydrogen peroxide (H2O2) in the induction of antitumor activity against chemically-induced rat hepatocellular carcinoma by sodium 5,6-benzylidene-L-ascorbate (SBA) was investigated. ESR spectroscopy demonstrated that rat liver homogenate of cancerous tissue significantly enhanced the radical intensity of SBA more potently than that of precancerous or normal tissue. The peroxyoxalate chemiluminescence method demonstrated that SBA significantly enhanced the production of H2O2-derived chemiluminescence intensity in the liver homogenates, and the effect of SBA was greater in cancerous tissue than in precancerous or normal tissue. Addition of ascorbic acid, a degradation product of SBA, showed similar but slightly weaker stimulation effects. These data suggest that antitumor activity of SBA in vivo might, at least in part, be due to H2O2 production.

Animals↗