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Biomedical subjects

M Takeuchi

Publications and source records attributed to M Takeuchi.

At least 739 records · Page 41Linked to original sources
PubMed1989

Effects of lower body negative pressure and volume loading on transmitral flow velocity pattern by pulsed Doppler echocardiography.

The transmitral flow (TMF) profile was studied in 18 patients with ischemic heart disease and in 4 patients with chest pain syndrome in order to clarify the dependency of preload alteration on the pattern of TMF. Pulsed Doppler echocardiography with simultaneous measurement of right-sided cardiac catheterization and M-mode echocardiography during lower body negative pressures (LBNP 0, -10 mmHg, -20 mmHg) and Dextran infusions (Dex 100 ml, 200 ml) were used in the study. After LBNP, peak velocities in rapid filling (peak R) (cm/sec) decreased (control; 68.3 +/- 13.9, LBNP-10 mmHg; 59.8 +/- 15.2, p less than 0.01, LBNP-20 mmHg; 55.2 +/- 11.0, p less than 0.01) and the integrals in the first half phase in rapid filling (IR1) (cm) also decreased (control; 4.0 +/- 0.8, LBNP-10 mmHg; 3.4 +/- 0.9, LBNP-20 mmHg; 3.2 +/- 0.9, p less than 0.05). During Dextran infusion, peak R (cm/sec) increased (control; 53.5 +/- 7.5, Dex 100 ml; 57.8 +/- 10.0, p less than 0.05, Dex 200 ml; 60.4 +/- 10.6, p less than 0.01) as did IR1 (cm) (control; 3.2 +/- 1.1, Dex 100 ml; 3.8 +/- 1.0, p less than 0.01, Dex 200 ml; 4.2 +/- 1.3, p less than 0.01). In conclusion, changes in preload may alter the peak velocity and the first half integral in left ventricular rapid filling depending on the pattern of transmitral flow velocity.

Adult↗
PubMed1989

The mechanism of inhibition of alveolar macrophages on autologous blood natural killer cell activity.

We investigated the mechanism of suppressive effect of alveolar macrophages (AM) on autologous blood NK cell activity in healthy nonsmokers (NS) and smokers (S). A 50 percent additional concentration of AM both in NS and S inhibited NK cell activity significantly (p less than 0.05). The degree of inhibition was not different in NS and S. Effects of prostaglandins (PG) and oxygen radicals were studied separately on the NK cell activity in the presence of AM. Indomethacin, catalase, or thiourea did not reverse inhibition of NK cell activity, but superoxide dismutase (SOD) prevented this phenomenon. These results suggest that the inhibition of NK cell activity by AM may be caused by O2 release rather than PG, H2O2, and OH.

Adult↗
PubMed1989

Role of right ventricular asynergy and tricuspid regurgitation in hemodynamic alterations during acute inferior myocardial infarction.

To elucidate the role of right ventricular asynergy and tricuspid regurgitation (TR) in hemodynamic alterations occurring during right ventricular infarction, left and right ventriculography with pressure measurements were performed in 22 patients with acute inferior myocardial infarction. Twelve patients with a proximal right coronary artery (RCA) occlusion (Group I) had elevated right atrial pressure (16 +/- 4 vs 8 +/- 5 mmHg, p less than 0.01), low cardiac output (2.5 +/- 0.7 vs 3.5 +/- 0.6 l/min/m2, p less than 0.05) and a greater degree of TR, compared with 10 patients with a distal RCA occlusion (Group II). Inferoposterior wall asynergy of the right and left ventricles was similar in Groups I and II. In Group I, there was an additional asynergy of the anterolateral free wall of the right ventricle. Cardiac output in those patients was not related to the left ventricular ejection fraction (EF) but to the right ventricular EF. A greater degree of TR was found in association with a lower right ventricular EF. The decrease in cardiac output was closely related to the extent of TR. These results indicate that right ventricular asynergy and TR due to proximal RCA occlusion may play important roles as causes of hemodynamic alterations seen during the acute phase of inferior myocardial infarction.

Aged↗
PubMed1989

Noninvasive assessment of left ventricular diastolic filling in coronary artery disease by Doppler dipyridamole-stress testing.

To evaluate left ventricular diastolic function during dipyridamole-provoked myocardial ischemia, transmitral flow was studied in 73 patients with coronary artery disease and 8 normal subjects using pulsed Doppler echocardiography. Coronary vasodilating agents like dipyridamole can provoke myocardial ischemia in patients with coronary artery disease. The peak flow velocity of left ventricular rapid filling (R), that of atrial contraction (A) and the ratio of A to R (A/R) in each cardiac cycle were measured. The rapid filling phase was divided into two subphases at the point of R. The integral of the two subphases and atrial contraction were computed and designated IR1, IR2 and IA. The time intervals of the two subphases of rapid filling were designated TR1 and TR2. Of the 73 patients with coronary artery disease, 41 patients developed ischemia (positive responder = PR) and 32 patients did not (negative responder = NR) after dipyridamole infusion. In PR, A/R increased (p less than 0.05), IR2 decreased (p less than 0.01) and TR2 shortened (p less than 0.01) significantly. In NR and normal subjects, these indices remained unchanged. We observed mitral regurgitation (MR) in 13 PR patients during acute myocardial ischemia. A/R increased in patients without MR but A/R remained unchanged in patients with MR. These results suggest that in acute myocardial ischemia, changes in Doppler indices (A/R, IR2 and TR2) reflect a left ventricular diastolic abnormality, and that the masking of the diastolic abnormality was ascribed to the presence of MR.

Blood Flow Velocity↗
PubMed1989

Quaternary ammonium glucuronide of croconazole in rabbits.

1. A water-soluble croconazole glucuronide was isolated from the urine of rabbits dosed intravenously with croconazole, using XAD-2 column chromatography, reversed-phase RP-8 column chromatography and h.p.l.c. 2. beta-Glucuronidase hydrolysis liberated unchanged croconazole from the glucuronide. 3. Secondary ion mass spectra, i.r. and n.m.r. spectroscopic studies, including two-dimensional n.m.r. techniques (ROESY and HETCOR), showed the metabolite to be a quaternary ammonium glucuronide of croconazole: i.e. a chemical bond exists between a nitrogen, having sp2 type orbital, in the imidazole ring of croconazole and the anomeric carbon of glucuronic acid. 4. The urinary excretion of the glucuronide amounted to 2.8 +/- 0.7% of dose (mean +/- SD, n = 4) in rabbits.

Animals↗
PubMed1989

[Mainz pouch using the appendix as the efferent limb].

Mainz pouch procedure requires intussuscepted ileum only at the efferent limb because ureters are tunneled into the colon wall in stead of the intussuscepted ileum as done in the Kock pouch procedure. We modified the Mainz pouch procedure using the tunneled appendix as the efferent limb in which intussuscepted ileum was no longer required. Four patients, three with bladder cancer and one with prostatic cancer, underwent this procedure. After total cystectomy and pelvic lymph-adenectomy the pedicled ileocecal segment was isolated. The appendix with the intact vascular supply was separated from the ileocecal segment. After the pouch was constructed, both the ureters and the appendix were tunneled into it. The pouch was then drained by a 24 Fr nephrostomy catheter. The ureters were splinted. The pouch was closed in one layer with locked running sutures. Three patients had ureteral strictures, 2 of which were corrected by percutaneous dilatation. The third one required persistent nephrostomy drainage. The appendix of all 4 cases functioned well as the efferent limb, preventing urinary leakage and allowing easy catheterization. Three of the 4 patients satisfied with this type of urinary diversion. The modified Mainz pouch procedure may be very useful because it does not require any staples to fix the intussuscepted ileum nor a long intestinal segment. Patients whose appendix can not be utilized may be candidates for the original Mainz pouch procedure.

Aged↗
PubMed1989

Fosfonochlorin, a new antibiotic with spheroplast forming activity.

A new antibiotic, fosfonochlorin, was found in the culture filtrate of four strains of fungi freshly isolated from soil samples. These strains were identified as Fusarium avenaceum, Fusarium oxysporum, Fusarium tricinctum and Talaromyces flavus. Fosfonochlorin was a low molecular weight antibiotic (MW 158), soluble in water and methanol, but insoluble in acetone, ethyl acetate and chloroform. It was named after its possession of phosphorus and chlorine atoms, each one molar in its structure. The structure was determined as chloroacetylphosphonic acid mainly by the 1H NMR and mass spectrometric analyses. It was moderately active against some species of Gram-negative bacteria and its synergistic effect with glucose-6-phosphate was observed on Staphylococcus aureus and Escherichia coli. Spheroplast formation of the susceptible organisms with this antibiotic suggested that it might inhibit their cell wall synthesis.

Anti-Bacterial Agents↗
PubMed1989

Preparation of 3-amino-3-deoxy derivatives of trehalose and sucrose and their activities.

The 3-keto derivatives of trehalose and sucrose respectively were prepared by a one-step enzymatic route using D-glucoside 3-dehydrogenase from Flavobacterium saccharophilum. Reductive amination of 3-ketotrehalose with ammonium acetate and sodium cyanoborohydride gave three compounds, 3-amino-3-deoxy-alpha-D-allopyranosyl alpha-D-glucopyranoside, 3-amino-3-deoxy-alpha-D-glucopyranosyl alpha-D-glucopyranoside (3-trehalosamine) and 3-amino-3-deoxy-alpha-D-mannopyranosyl alpha-D-glucopyranoside. From the reductive amination of 3-ketosucrose, 3-amino-3-deoxy-alpha-D-allopyranosyl beta-D-fructofuranoside and 3-amino-3-deoxy-alpha-D-glucopyranosyl beta-D-fructofuranoside were obtained. The antibiotic and glycohydrolase inhibitory activities of these 3-amino-3-deoxy derivatives were determined.

Amination↗
PubMed1989

[Acoustic investigation of various palatal rugae].

We use some palatal plates with some Kinds of palatal rugae; ready made, patterned, individually copied and omitted, and studied the influence of the pronunciation acoustically concerning the Formant Frequency.

Dental Impression Technique↗
PubMed1989

[Importance of posterior discrepancy in the development of skeletal Class III malocclusion].

The purpose of this communication is to explain regarding with relationship between the development of skeletal Class III malocclusion and the tooth-to-denture base discrepancy especially those in the posterior part of dentition (posterior discrepancy). Four cases which had skeletal Class III malocclusion and had experienced unsuccessful orthodontic correction were presented to evaluate the causative factors of skeletal Class III malocclusion. The observation of serial cephalograms led us to the conclusion that the continuous forward displacement of the mandible was associated with superversion of maxillary and/or mandibular molars caused by the "squeezing out" effect of poterior discrepancy. Moreover, superversion of molar provides a less steep maxillary occlusal plane in the denture frame. Accordingly, a vertical expression of the posterior discrepancy may provide one of the best explanation for development of skeletal Class III malocclusion.

Humans↗
PubMed1989

[Influence of preload alteration on the transmitral flow velocity in patients with old myocardial infarction: effects of nitroglycerin and lower body negative pressure].

We studied the influence of preload alteration on the pattern of transmitral flow as obtained by pulsed Doppler echocardiography. In protocol I, 14 patients with old myocardial infarction (OMI) were observed by simultaneous measurements of transmitral flow by PDE and left ventricular end-diastolic dimension (LVDd) using M-mode echocardiography during the control period and after sublingual nitroglycerin. In protocol II, eight patients with OMI were similarly observed during stepwise lower body negative pressure (LBNP: 0, -10 and -20 mmHg). The rapid filling phase was categorized in two subphases at peak R as the first half and second half phases. The integrals of each half phase and the atrial systolic phases (IR1, IR2 and IA) were measured by planimetry. After the administration of nitroglycerin, LVDd decreased significantly; whereas the mean arterial pressure decreased and heart rate increased significantly. The peak R and IR1 decreased significantly, but the peak A, IR2 and IA remained unchanged. During LBNP, LVDd decreased stepwise; whereas there was no change in the mean arterial pressure or heart rate. The changes in the peak R and IR1 paralleled the preload reduction during LBNP. The peak A, IR2, and IA remained unchanged. In conclusion, the first and second half volumes during the LV rapid filling phase can be influenced by various factors. The patterns of the transmitral flow velocity, the maximal velocity and first half volume in the LV rapid filling phase may be influenced by preload alteration.

Adult↗
PubMed1989

[A case of recurrent Epstein-Barr virus meningitis].

A 17-year-old male was admitted to our hospital complaining of fever, headache and nausea. On physical examinations cervical and inguinal lymphadenopathy and hepatosplenomegaly were noted. Neurological examination revealed meningeal signs. Blood examination showed slightly increased lymphocytes and atypical lymphocytes (1-4%), increased ESR, CRP (2+), slightly elevated EBV VCA IgG (X20), and normal EBV VCA IgM (less than X 10). Initial pressure of CSF was 195mmH2O, cells 46/3mm3, protein 50mg/dl. Slowing of back ground activity of EEG such as theta and delta wave was noted. CT scan revealed normal. During the course EBV VCA IgG elevated to X160, EBV VCA IgM elevated to X20. Slight respiratory disturbance, photophobia, and dysosmia were noted. One month later, clinical symptoms and laboratory data improved, the patient was discharged. Forty days after the discharge, headache was excerbated and increased CSF protein (100mg/dl) and pleocytosis (33/3mm3) were noted. The patient was readmitted to the hospital. After 2 weeks in the hospital, symptoms were diminished and laboratory findings revealed normal. During 2 years before the third admission he was asymptomatic and could enjoy the college life. At age 19, he was admitted to our hospital complaining of fever, headache and nausea. Neurologically slight meningeal irritation was noted. Blood examination revealed 1% atypical lymphocytes. EBV VCA IgG was elevated (X320) and EBNA was X80. CSF protein was slightly increased (52mg/dl). During the clinical course CSF protein was elevated to 105mg/dl and cell count to 502/3mm3 (N: L = 27: 409, with 66 atypical lymphocytes). Persistent hiccup was noted. After 50 days CSF findings were improved and he was discharged.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1989

[A case of coronary artery fistula with angina pectoris].

A case of coronary artery fistula with myocardial ischemia is reported. A 57-year-old-man was admitted to our hospital complaining of anterior chest pain on exertion. Submaximal Treadmill exercise showed the depression of ST segment in leads II, III, aVF, V5 and V6. 75% stenosis of right coronary artery (segment 2) and congenital coronary artery fistula originating from both the right and left coronary arteries were demonstrated by the coronary arteriography. One abnormal artery was originated from proximal portion of the right coronary artery (segment 1) and entered the pulmonary artery trunk. Another one was originated from proximal portion of the left coronary artery and terminated in angiomatous plexus which then communicated with the pulmonary artery trunk. We speculate that myocardial ischemia resulted from decreased right coronary blood flow due to coronary steal and proximal organic stenosis of right coronary artery. Recently, the reviews of coronary artery fistula are increasing, but coronary artery fistula with myocardial ischemia is relatively rare. This case was followed with medical therapy, because antianginal agents were effective. Operative coronary ligation may be necessary, if he has angina or high output heart failure during follow-up.

Angina Pectoris↗
PubMed1989

[Treatment of acute lymphocytic leukemia in adult].

Since April, 1978 to October, 1988, 66 acute lymphocytic leukemia (ALL) patients aged 15 to 79 (21 L1, 43 L2, 2 L3/6 Ph1+) were treated with 3 different therapeutic protocols. The drugs used for induction were VCR (VDS) + Pred, followed by DNR + VCR (VDS) + 6MP + Pred and VCR (VDS) + L-asp + Pred in protocol I, Ad + VCR + Pred in protocol II and DNR + VCR + Pred in protocol III. Complete remission (CR) was attained in 72.7% of 66 patients. The CR rate of each group as followings; 71.4% in protocol I and 75.0% in protocol II and III, respectively. The median duration of remission was 10.2 months + and the probability of being in continuous CR at 3 years was 21.9%. For the 48 patients in remission the median survival was 17.8 months and the probability of being alive at 3 years was 24.3%. The intensified induction and consolidation therapy is expected in the cure oriented treatment of adult ALL.

Adolescent↗
PubMed1989

[Morphological study on open bite patients].

The purpose of the present study is to investigate the morphological features of open bite patients who have also disharmony of anteroposterior relations between maxilla and mandible. Lateral head films of 40 adult females with open bite were used. The samples were classified into three groups by ANB angle. Three groups were as follows. 1. Type I open bite (12 subjects, 1 degree less than or equal to ANB less than or equal to 4.5 degrees). 2. Type II open bite (13 subjects, ANB less than 4.5 degrees). 3. Type III open bite (15 subjects, ANB less than 1 degree) The normal samples was the longitudinal data of females in our department. Skeletal and dental variables were calculated and compared norm versus type I open bite, type I open bite versus type II open bite and type I open bite versus type III open bite, respectively. The following results were obtained. 1. Disharmony of the vertical dimensions in type I open bite was mainly due to long anterior lower facial height which was accompanied by large gonial angle as compared with norm. 2. There were no difference in anteroposterior position of the maxilla and nasal floor in all three open bite groups. 3. There were no difference in anterior and posterior facial height between type I and type II open bite. However, type II open bite showed the backward rotation of the mandible accompanied by over eruption of upper first molars. 4. Type III open bite showed longer anterior lower facial height which was caused by excessive mandibular growth than type I open bite. 5. Upper incisors showed labial inclination as compared with norm in all three open bite groups. However, lower incisors showed labial inclination in type II open bite and lingual inclination in type III open bite as compared with type I open bite. As a result, the inter-incisal angle was small in type II open bite and large in type III open bite as compared with type I open bite. These results suggested that the dentoalveolar factors were large in type II open bite and the skeletal factors were large in type III open bite as compared with type I open bite.

Cephalometry↗
PubMed1989

[Observation on calcification of necrotic tissue in pressure side of periodontal membrane incident to experimental tooth movement].

In an orthodontic point of view, it is said that necrotic tissues cause a standstill of tooth movement until they disappear and that term of the standstill is related to the size of the necrotic tissues. Although remodeling processes of a periodontal membrane in compressed area were reported as series of phenomena like degeneration, coagulative necrosis, calcification and histiolysis, there is no direct evidence that the necrotic tissue is really calcified. The purpose of this study is to clarify histologically whether the necrotic tissues in the periodontal membrane are calcified or not and to know when appearance and disappearance of the calcification occur during an experimental tooth movement. Twenty eight rats were used for this study. For the experimental tooth movement, the orthodontic elastics were inserted into the interproximal space between the maxillary right 1st and 2nd molars during 1, 2, 3, 5, 7 and 14 days respectively (Waldo's method). The periodontal tissues were observed on undecalcified sections by vital staining in which oxytetracycline (3 mg/kg), alizarin red (8 mg/kg) and calcein (0.8 mg/kg) were applied as well as by contact micro radiography (CMR). Findings were as follows: 1) After 2 days of tooth movement, a part of the periodontal membrane in compressed area showed fluorescence by vital staining and was radiopaque by CMR. This means that the necrotic tissues are really calcified at least after 2 days of experimental tooth movement. 2) After 7-14 days no calcified tissue could be found in the periodontal membrane. The calcified tissues may disappear under processes of resorption in this area.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗