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Biomedical subjects

M Takamiya

Publications and source records attributed to M Takamiya.

At least 163 records · Page 9Linked to original sources
PubMed1986

Coronary arterial lesions of Kawasaki disease: cardiac catheterization findings of 1100 cases.

In our institute, 1100 patients with a history of Kawasaki disease have been catheterized for selective coronary arteriography. Their age at examination ranged from four months to 13 years. Coronary artery lesions (CAL) were found in 262 patients. As far as the type of the CAL was concerned, occlusion was noted in 20 (7.6%), segmental stenosis in 15 (5.7%), localized stenosis in 62 (23.7%), aneurysm in 93 (35.5%), and dilatation in 72 patients (27.5%). In terms of the total number of lesions, there were 23 occlusions, 19 segmental stenoses, 109 localized stenoses, 449 aneurysms and 307 dilatations. The 262 patients with CAL were analyzed according to the interval from the onset to the time of selective coronary arteriography. The incidence of both occlusion and segmental stenosis was lowest in the group who were catheterized shortly after the onset of disease, whereas the prevalence of aneurysm was highest in this group. But the prevalence of dilatation was highest in the group of patients who were catheterized late. A total of 12 patients had to undergo femoral arterial thrombectomy for arterial thrombosis following the catheterization, but no other major complication was experienced.

Biopsy↗
PubMed1986

Hemolytic, lethal and edema-forming activities of the skin secretion from the oriental catfish (Plotosus lineatus).

The crude extract from the skin secretion of the oriental catfish, Plotosus lineatus, contained at least one hemolysin, two lethal factors and two edema-forming factors; the lethal and edema-forming factors seem to be identical. The molecular weights of the hemolysin and the lethal factors (edema-forming factors) were estimated to be 180,000 and 12,000, respectively. Peculiar secretory cells, which resembled the venom glandular cells of the dorsal and pectoral stings, were observed in the epidermis.

Animals↗
PubMed1986

Semiquantitative grading of severity of mitral regurgitation by real-time two-dimensional Doppler flow imaging technique.

An attempt was made to determine whether mitral regurgitation could be detected and its severity evaluated semiquantitatively by newly developed real-time two-dimensional Doppler flow imaging in 109 patients who underwent left ventriculography. In the Doppler flow imaging technique, Doppler signals due to blood flow in the cardiac chambers are processed using a high speed autocorrelation technique, so that the direction, velocity and turbulence of the intracardiac blood flow are displayed in the color-coded mode on the monochrome B-mode echocardiogram in real time. Mitral regurgitant flow was imaged as a jet spurting out from the mitral valve orifice into the left atrial cavity. It was noted that the regurgitant jet in the left atrial cavity had a variety of orientations and dynamic features when studied by the present technique. The sensitivity of the technique in the detection of mitral regurgitation was 86% as compared with that of left ventriculography. Mitral regurgitation in the false negative cases was mostly mild. On the basis of the farthest distance reached by the regurgitant flow signal from the mitral valve orifice, the severity of regurgitation was graded on a four point scale and these results were compared with those of angiography. A significant correlation (r = 0.87) was found between Doppler imaging and angiography in the evaluation of the severity of mitral regurgitation. A similar result was obtained for the evaluation based on the area covered by the regurgitant signals in the left atrial cavity. Thus, noninvasive semiquantitative evaluation by real-time two-dimensional Doppler flow imaging appears to be a promising clinical technique.

Adolescent↗
PubMed1985

False lumens in type III aortic dissections: progress CT study.

The fate of false lumens in 13 patients having Type III aortic dissections was studied using computed tomography (CT). Contrast media filled false lumens with or without thrombosis were observed in ten patients; the false lumens of three patients were entirely thrombosed at initial examination. Follow-up CT studies showed shrinkage or disappearance of the false lumens with thrombosis in four patients, progression of thrombosis in two patients, and enlargement of the false lumen in one patient who subsequently required surgical repair. No change was observed in the remaining six patients during our observation period. CT study provides useful information for evaluating the efficacy of medical treatment and the timing of surgical intervention during follow-up evaluation of medically treated Type III aortic dissections.

Adult↗
PubMed1985

Myocardial perfusion assessed by digital subtraction angiography.

Perfusion of each myocardial portion in ischemic heart disease was assessed by digital subtraction angiography (DSA). There were 45 cases of ischemic heart disease and five normal controls. The contrast medium was 40 ml 76% Urografin which was injected into the central vein at a rate of 16 ml/sec using a 5F thin-wall catheter. A myocardial image was extracted, and a time-density curve for the corresponding portion was obtained. In the normal controls, the density was maximum in systole with a gradual decrease in diastole. In all myocardial infarction cases, the wave pattern disappeared. In the group whose infarcted areas were small (26 of the 45 cases), 22 (85% of of the 26 cases) exhibited slowly increasing pattern. In the group whose infarcted areas were large (19 of the 45 cases) 15 cases (79%) had plateau type pattern. Observations of the perfusion of the myocardium using DSA facilitated quantitative diagnoses of the infarcted areas and forecasts of myocardial viability.

Adult↗
PubMed1984

Clinical efficacy, extrapyramidal symptoms and serum levels: influence of administration schedules and concomitant drugs on serum bromperidol concentrations.

Bromperidol (4 or 12 mg per day) was administered to 18 newly admitted schizophrenics and 29 chronic schizophrenic inpatients once or four times a day and the two dose schedules were compared. The bromperidol levels in the four-times-a-day group were significantly higher than those in the once-a-day group and the daily variation in the serum level of the agent was markedly wider in the latter than in the former patients. The incidence and severity of extrapyramidal symptoms were not significantly different between the two. A clear relationship was not present between the serum levels and the development of extrapyramidal symptoms. The bromperidol serum values were not correlated with the therapeutic response but, at more than 5 ng per ml, there might be a positive correlation between the bromperidol levels and clinical efficacy in the newly admitted schizophrenics. As for concomitant medication, levomepromazine may raise the bromperidol serum level. An anti-parkinson drug failed to depress the bromperidol level.

Adult↗
PubMed1984

[Digital subtraction angiography of the cerebral vessels by intraarterial injection].

Three hundred and fifty-seven digital subtraction angiography (DSA) were performed in 184 neurosurgical patients by intraarterial injection. Examinations consisted of 192 carotid angiography, 110 vertebral angiography, 23 aortography, 11 spinal angiography and 21 other angiography. In all examinations, visualization of the vessels was excellent and the complications were never experienced. High contrast sensitivity of DSA resulted in better visualization of tumor stains, phlebogram, and arteries in cerebral arteriovenous malformations with large shunt blood flow than conventional angiography. Selective catheterization into each cerebral arteries was not necessarily demanded for good opacification of the vessels because of high sensitivity. High contrast sensitivity also permitted low concentration of contrast material, small dose of contrast material, and slow injection rate. Low concentration of contrast material reduced pain and heat during injection especially in the external carotid and vertebral angiography. Using slow injection, recoiling of catheter into the aorta was reduced, so that injection from the innominate and subclavian arteries for visualization of origin of the cerebral arteries were always successful. Full study of cerebral arteries by Seldinger's method, if necessary, was easily achieved using DSA even in patient with high age or with severe atherosclerosis. Bolus injection of small dose of contrast material as well as serial imaging was helpful in evaluating hemodynamics in the lesion. Real time display of DSA reduced the time required for angiography and was very convenient for artificial embolization. Besides these advantages, DSA became comparable to conventional angiography in special resolution by use of intraarterial injection and could be a preoperative genuine examination as well as a screening method.

Adolescent↗
PubMed1984

[Evaluation of right ventricular wall contractility in ischemic heart disease by cardiac computed tomography].

One hundred and eight cases with ischemic heart disease except for acute myocardial infarction were examined by cardiac computed tomography with ECG-gated scanning. The right ventricular (RV) wall contractility was evaluated by the long-axial and short-axial CT images in terms of (a) contraction rate of the RV area, (b) shortening rate of the RV free wall and (c) changes in the thickness of the RV free wall in cardiac cycle. These parameters were compared to the findings of coronary angiography and left ventriculography. 1. There was no difference of the contraction rate of the RV area between the cases with severe (90-100%) right coronary (RCA) stenosis and those with mild (0-75%) stenosis, while the contraction rate of the RV area was markedly decreased in the former combined with the impaired contraction of the ventricular septum. Consequently, it was assumed that RV function is hardly damaged by RCA lesion alone, and that the contraction rate of the RV area is not a suitable parameter for the assessment of the severity of RCA stenosis. 2. The shortening rate of the RV free wall in the long-axial image in cases with severe RCA stenosis was significantly decreased (14.5 +/- 4.6%) compared with that of mild stenosis (27.8 +/- 5.0%). The changes in the thickness of the RV free wall were also impaired in severe RCA stenosis. Same tendency was observed in the short-axial image, while the correlation between RCA stenosis and impaired contraction of the RV free wall was much more evident in the long-axis image than in the short-axis image. As the result, reduced RV contraction due to RCA ischemia seems to exist not only in acute myocardial infarction but also in chronic stage of the ischemic heart. 3. CT method is suitable for the evaluation of RV ischemia due to RCA lesion because the contractility of the RV free wall can be assessed independently of ventricular septal contraction. In cases with reduction of the free wall shortening rate under 20% combined with poor change in the thickness of the RV free wall, severe stenosis of the RCA should be suspected.

Angiography↗