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Biomedical subjects

M Takada

Publications and source records attributed to M Takada.

At least 757 records · Page 42Linked to original sources
PubMed1977

Effects of cadmium on the active transport of sodium by the abdominal skin of a bullfrog (Rana catesbeiana).

Effects of Cd on the active transport of Na in SO4-Ringer's solution on the abdominal skin of a bullfrog (Rana catesbeiana) were investigated. The short circuit current (SCC), potential difference (PD), and Na flux were determined. The skin resistance (Rm), the electromotive force of active Na transport (Ena), and the resistance to the active Na current (Rna) were calculated from the measured data. The application of Cd to the epidermal side at 2 mM was more effective in increasing SCC than that to the dermal side at the same concentration. The time course of changes in SCC induced by Cd were classified into three types: (I) a simple increase in SCC during Cd application, (II) an early decrease followed by an increase in SCC, and (III) a decrease in SCC except for a small increase in the initial short period. Type I response was observed in the majority of cases (about two-thirds). Types II and III were observed in 7 and 32 percent of 28 cases, respectively. The Cd-induced changes in SCC were analyzed on the basis of changes in ENa and RNa. In Type I, the increase in SCC was due to a remarkable decrease in RNa without an appreciable change in ENa (since SCC = ENa/RNa). In Types II and III, the changes in SCC in the early and the later stages could be explained by the differences in the extents to which ENa and RNa decreased. The experimental and calculated ratios of PDcd to PDcontrol in these stages were in good agreement with each other.

Abdominal Muscles↗
PubMed1977

Studies on aculeacin. I. Isolation and characterization of aculeacin A.

Aculeacin A, a new antifungal antibiotic was isolated from the mycelial cake of Aspergillus aculeatus M-4214. The antibiotic is a white amorphous powder soluble in lower alcohols and hardly soluble in other organic solvents or water. Aculeacin A gave palmitic acid and five ninhydrin-positive products including theonine, hydroxyproline upon acid hydrolysis. The antibiotic showed a potent activity against molds and yeasts, but exhibited no antibacterial activity. Aculeacin A has relatively low toxicity in mice.

Amino Acids↗
PubMed1976

Adjuvant immunotherapy in bronchogenic carcinoma.

Ten patients with locally far advanced bronchogenic carcinoma were treated with autologous tumor vaccine after a radical surgical resection. Three of 10 patients treated with tumor vaccine are alive (median survival of 26 months) whereas all nine patients in the control group are dead (median survival of 6.5 months). Active immunotherapy adjunct to radical surgery appeared to improve cellular immunity of the treated patients in the postoperative period, and the migration inhibition test indicated sensitization of treated patients against their tumor.

Antigens, Neoplasm↗
PubMed1975

Inhibition of PHA-induced lymphocyte stimulation by factors in maternal serum during late pregnancy.

Immunosuppressive effect of pregnant serum obtained in the second and third trimesters was demonstrated in the PHA-induced homologous lymphocyte stimulation system, where 3H-thymidine incorporation into DNA was measured. Such an inhibitory factor was not present in the first trimester serum. The immunosuppressive principle detected in the second trimester serum was characterized by a potent inhibitory activity even at an increased concentration of PHA up to 75 micrograms, whereas the inhibitory activity found in the third trimester serum at optimum PHA concentration (15 micrograms) was not detectable when the PHA concentration was raised to 75 micrograms. Thus, the second and third trimester sera must contain different immunosuppressive principles.

Female↗
PubMed1975

Inhibitor of PHA-induced lymphocyte blastformation generated from maternal lymphocytes during early pregnancy.

The supernatant of phytohemagglutinin (PHA)-stimulated lymphocyte culture derived from pregnant women in the first two trimesters inhibited DNA synthesis of normal human lymphocytes after PHA induction. This soluble factor was heat-labile and the same factor could not be found in the supernatant generated from lymphocytes of pregnant women in 3rd trimester as well as from those of the non-pregnant. In contrast, the heatstable factor in the supernatant generated from lymphocytes of non-pregnant women in all trimesters contained an stimulating factor on the DNA synthesis of normal human lymphocytes after PHA induction. An endogenous alternation in lymphocyte competence or an alternation in subpopulation of lymphocytes was suggested at the early stage of pregnancy.

Female↗