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Biomedical subjects

M Takác

Publications and source records attributed to M Takác.

At least 19 recordsLinked to original sources
PubMed1992

Levels of cardiovascular risk factors in type 2 diabetes mellitus are dependent on the stage of proteinuria.

Levels of cardiovascular risk factors were determined in 75 patients with Type 2 diabetes mellitus. The patients were divided into three groups according to their urinary protein excretion (UPE): (a) normal proteinuria (less than or equal to 70 mg d-1); (b) microproteinuria (70-500 mg d-1); and (c) macroproteinuria (greater than 500 mg d-1). A significant stepwise increase in mean systolic blood pressure, LDL-cholesterol and fibrinogen levels was observed from the first to the third investigated group of patients. Mean apoprotein B levels were significantly increased in the group with macroproteinuria compared to the other two groups. Significant linear correlations were found between UPE and LDL-cholesterol, total cholesterol, apoprotein B, creatinine, systolic blood pressure and diabetes duration. In summary, it is concluded that the levels of some cardiovascular risk factors increase with the stage of proteinuria in Type 2 diabetes mellitus.

Aged↗
PubMed1992

Microinjection of cloned proviral Rous sarcoma virus DNAs into Xenopus laevis one cell embryos.

Plasmid pATV8 carrying Rous sarcoma virus (RSV) DNA with one long terminal repeat (LTR) or plasmid pAPrC carrying complete RSV proviral DNA was injected into fertilized eggs of Xenopus laevis. The fate of the exogenous DNAs was followed during embryogenesis. In both cases a new form of DNA, comigrating with endogenous DNA, began to appear shortly after the injection. This new form represented a linear dimer of the injected plasmid that had formed by ligation of linear monomers of the plasmid DNAs. All forms of the exogenous pATV8 DNA disappeared gradually during neurulation. No traces of virus-specific RNA were ever found in any of the following stages. The intensity of replication of plasmid pAPrC DNA in fertilized eggs was greater than that of pATV8 DNA and, in contrast to pATV8, a small amount of pAPrC persisted through the neurula till higher stages. In some experiments virus-specific DNA was even observed in 6-day-old embryos. Digestion with Nsi I and Sac I proved integration of the plasmid into the frog genome. At the stage of gastrula and at later stages a weak signal of viral RNA was also detected.

Animals↗
PubMed1992

[A case of systemic mastocytosis].

The authors describe a rare case of systemic mastocytosis without skin infiltration. The first symptom were episodes of flushing in the face and upper trunk. From the case-history it was assumed that the condition had a several year's benign course, the diagnosis was established in the stage of malignant acceleration of the disease from bone marrow biopsy and liver biopsy. Atypical mastocytes displayed metachromasia with toluidine blue and positive naphthol-AS-D chloroacetate esterase. Symptomatic treatment with sodium cromoglycate reduced temporarily the frequency of flushing episodes, but it was not possible to arrest the increase of the mastocyte mass by cytostatic treatment.

Bone Marrow↗
PubMed1992

Risk factors for atherosclerosis in female type II diabetic patients with incipient diabetic nephropathy.

Risk factors for atherosclerosis were investigated in a group of 17 female Type II diabetic patients with microalbuminuria-urinary albumin excretion (UAE) in the range of 30-300 mg/day, and in a control group including 15 Type II diabetic females with UAE less than 30 mg/day. Significantly increased mean concentrations of total and LDL-cholesterol were measured in the group with microalbuminuria (p less than 0.05). Also mean levels of some other cardiovascular risk factors (systolic blood pressure, fibrinogen, apolipoprotein B, triglycerides and uric acid) were higher in the group of patients with microalbuminuria, although the differences in comparison to the control group did not reach the level of statistical significance. In the multiple stepwise regression analysis log transformed UAE values correlated significantly with three independent factors--uric acid (p less than 0.01), fibrinogen (p less than 0.05), and systolic blood pressure (p less than 0.05). It is concluded that a slight increase in the levels of a number of cardiovascular risk factors observed in incipient diabetic nephropathy suggests an additive effect favouring atherogenesis.

Albuminuria↗
PubMed1992

Hematologic changes in type 2 diabetic patients with various localizations of peripheral vascular disease.

Some hematologic parameters have been measured in 80 patients with Type 2 diabetes mellitus. The patients were divided into three groups: (a) proximal (pelvic and femoral) lower limb macroangiopathy; (b) distal (tibial) macroangiopathy; and (c) control group of diabetics without lower limb macroangiopathy. Mean hemoglobin, hematocrit and fibrinogen values were significantly higher in both the proximal and distal macroangiopathy groups in comparison with the controls. On the other hand, mean leucocyte and platelet counts were significantly elevated only in the proximal macroangiopathy group. Significant correlations were observed in univariate and multivariate analyses between blood fibrinogen concentration and pressure indices expressing severity of lower limb macroangiopathy (ankle/thigh, ankle/arm). In summary, increased levels of hematologic parameters contributing to the increase of whole blood viscosity were observed in Type 2 diabetics with arteriosclerosis obliterans. The observed relationship between fibrinogen concentration and severity of arteriosclerosis obliterans could be an evidence in favor for fibrinogen lowering therapy in this pathologic condition.

Arteriosclerosis Obliterans↗
PubMed1992

[Characteristics of diabetic macroangiopathy of the lower extremities].

Macroangiopathy of the lower extremities is one of the most frequent complications of diabetes and has a very adverse impact on the quality of life of the patients. It affects approximately as much as half the diabetics with the duration of the disease for more than 15 years. It is encountered in two forms. The first type of affection--obliterating atherosclerosis--reminds of affections of the arteries of the lower extremities in the non-diabetic population, although some differences in the site of affection, morphology of sclerotic changes as well as the spectrum of risk factors were found, when compared with obliterating atherosclerosis in non-diabetics. Risk factors of this form of macroangiopathy include cholesterol, triacylglycerols, reduced values of HDL-cholesterol, hypertension, fibrinogen, smoking and apparently also albuminuria. The second form of macroangiopathy--mediocalcinosis--is not associated with the mentioned risk factors of atherosclerosis but is probably the consequence of diabetic neuropathy. Contrary to atherosclerosis, it does not lead to the development of obliteration but has also an adverse effect on the function of blood vessels. Its incidence correlates with the duration and compensation of diabetes as well as deteriorated perception of vibrations. With regard to the high incidence of gangrenes requiring amputation, it seems rational to influence in diabetics all known risk factors of macroangiopathy although convincing results of long-term intervention studies are still lacking.

Diabetic Angiopathies↗
PubMed1992

[ECG Holter monitoring in patients with chronic renal failure in a long-term dialysis program].

Using the Holter method, the authors monitored for 24-hours 30 patients included in a long-term dialyzation programme during and after haemodialysis. A group of 15 patients who had during examination frequent or complex supraventricular or ventricular ectopia was compared with a group of 15 patients with sporadic ectopia. In the arrhythmic group paroxysmal supraventricular tachycardia was recorded in 33% and paroxysmal atrial fibrillation in 13%, polytopic or repetitive ventricular extrasystoles in 14%, couplets in 20% and volleys of ventricular extrasystoles or non-persisting ventricular tachycardia in 20%. Comparison of clinical laboratory and echocardiographic characteristics revealed in the arrhythmic group significantly higher mean ages of patients, higher levels of ionized serum calcium before haemodialysis, C terminal parathormone, the breadth of the interventricular septum, and the authors observed also a higher incidence of hyperechogenity of cardiac structures. On analysis of repolarization ECG changes significant asymptomatic depressions of the ST segment were found which were transient and dominated during the early posthaemodialyzation period in 11 patients of the whole group (37%).

Adult↗
PubMed1992

[Creatine kinase and lactate dehydrogenase in the early diagnosis of acute myocardial infarct].

The authors investigated in a group of 504 patients--357 men and 147 women with acute myocardial infarction on admission to hospital--the relationship between the ECG finding and values of catalytic concentrations of isoenzymes CK-MB and LD-1 LD-2. They found that isoenzymes CK-MB and LD-1 LD-2 are a more sensitive indicator of acute IM than the ECG tracing. Not even a negative ECG tracing when the total catalytic concentrations of CK and LD are not elevated rules out the possibility of acute myocardial infarction.

Clinical Enzyme Tests↗
PubMed1992

[Pulmonary embolism as a rare complication of a contusion in the inguinal region].

In the submitted case-history the authors describe the clinical case of an adolescent patient who developed phlebothrombosis of the right ileofemoral area one year after a blunt injury in the scrotal and right inguinal area. The symptoms of pulmonary embolism were detected sooner than the symptoms of phlebothrombosis. Two-dimensional echocardiography provided valuable information when the authors monitored the dynamics of changes in acute cor pulmonale and the effect of administered treatment.

Adolescent↗
PubMed1990

Different levels of cardiovascular risk factors in type-2 diabetic patients with lower limb proximal and distal vessel macroangiopathy.

The levels of some cardiovascular risk factors (lipids, apolipoproteins and fibrinogen) were measured in groups of Type-2 diabetic patients with lower limb proximal (ileofemoral) and distal (trifurcational) artery macroangiopathy, diagnosed by Doppler ultrasound, and in a group of diabetics without macroangiopathy. The highest mean levels of total and LDL-cholesterol, apolipoprotein B and triacylglycerols were observed in patients with proximal vessel involvement. Significant correlations were found between the thigh/arm index and total cholesterol, LDL-cholesterol, apolipoprotein B and stroke prevalence. On the other hand, a significant correlation was found between ankle/thigh index and fibrinogen. The results of the study suggest that different pathogenetic mechanisms may play a role in the development of ileofemoral and trifurcational vessel disease.

Apolipoproteins B↗
PubMed1990

Accumulation of the risk factors of atherosclerosis in type-II diabetics with hypertension.

The incidence of arterial hypertension and some clinical and biochemical parameters were followed in relation to hypertension in a group of 156 hospitalized Type-II diabetics. A significant correlation was demonstrated between the values of systolic blood pressure and cholesterol levels (r = 0.30, p less than 0.001), between systolic blood pressure and diabetes duration, and between systolic blood pressure and triglyceride levels in all our patients. Similarly, a significant correlation was found between diastolic blood pressure and the levels of cholesterol (r = 0.27, p less than 0.001), triglycerides and urea. Hypertension was diagnosed in 65% of the group of hospitalized diabetics. Hypertensive diabetics showed a significantly higher proportion of women and a higher mean cholesterol level (6.1 +/- 2.2 mmol/l) compared with the group of diabetics free of hypertension (4.8 +/- 1.4 mmol/l), with the same mean age, diabetes duration and weight. Of the complications of diabetes, the hypertensive group, compared with the control group, were found to have only a significantly higher incidence of cerebrovascular events (31% vs 6%, respectively). The incidence of myocardial infarction and proteinuria were only insignificantly higher in the hypertensive group. We can conclude, on the basis of our results, that the risk factors of atherosclerosis (hypertension, cholesterol, triglycerides) accumulate in the group of Type-II diabetics. This is apparently due to hyperinsulinaemia often present in Type-II diabetics with impaired glucose tolerance. Another factor possibly contributing to the increased incidence of hypertension is the increase in blood viscosity in hyperlipoproteinaemia.

Aged↗
PubMed1989

[The effect of sodium levels in dialysis solutions on the distribution of total body water during hemodialysis].

Thirty-seven haemodialyses with ultrafiltration were performed (3000 ml/6 hours). using three sodium concentrations (140, 145 and 150 mmol/l) in the dialysate solution in 16 hyperhydrated patients during a long-term dialysis program. The amount of eliminated sodium during haemodialysis depended on the sodium concentration in the dialysate solution. The reduction of the volume of total body water corresponded to ultrafiltration. When a sodium concentration of 150 mmol/l in the dialysate solution was used, the smallest diminution of extracellular fluid and greatest diminution of intracellular fluid was observed. At the same time the greatest transport of water from the intracellular into the extracellular fluid was recorded. A sodium concentration of 145 and 150 mmol/l in the dialysate solution gave rise to positive values of sodium-free water and of sodium-free water clearance. Sodium-free water and of sodium-free water clearance correlated directly with the sodium concentration in the dialysate solution and inversely with the amount of eliminated sodium. The patients were free from complaints during haemodialyses and no significant blood pressure changes were found. The dialysate solution with the sodium concentrations used is suitable for a long-term dialysis programme; the authors recommend, however, to use individual sodium concentrations, depending on the patient's clinical condition.

Adult↗
PubMed1987

Lack of synthesis of pentamer IgM in Xenopus oocytes after injection of poly(A)+ RNA from hybridoma cells.

Total poly(A)+ RNA was isolated from B cell hybridomas producing monoclonal antibodies of the IgM class specific for sheep red blood cells. These RNAs were microinjected into Xenopus oocytes and the translation products were analyzed. Unlike the hybridoma cells, the oocytes synthetized only the light chains and oligomer IgM, but evidence for assembly of functional pentamer IgM was not obtained. The possible reasons for these differences are discussed.

Animals↗
PubMed1986

Urinary excretion of vitamin C in chronic renal failure and after renal transplantation.

Urinary excretion of vitamin C was investigated in 44 patients with chronic renal diseases and in 25 patients after renal transplantation with various mean glomerular filtration rates. In both groups a hyperbolic relationship was observed between FE vitamin C and CCr. In addition, direct relationships were found between FE vitamin C and FE Na, FEK and FE H2O in both groups. Various chronic renal diseases and treatments had no influence on the investigated relationships. In 16 healthy subjects urinary excretion of sodium during maximal water diuresis did not increase but urinary excretion of vitamin C significantly increased. In 10 patients in the polyuric stage of chronic renal failure without dialysis treatment during Giordano-Giovanetti-Maggiora diet with addition of sodium chloride the urinary excretion of sodium increased but that of vitamin C was not influenced. The results obtained for the biochemical parameters tested suggest that the urinary excretion of vitamin C depends on the urinary excretion of water.

Adult↗