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Biomedical subjects

M Tadokoro

Publications and source records attributed to M Tadokoro.

At least 163 records · Page 9Linked to original sources
PubMedDate not supplied

Videotaped helical CT images for lung cancer screening.

PURPOSE: The goal of this work was to determine a radiologist's ability to detect solitary pulmonary nodules on helical CT using both video (cine) viewing and film-based viewing. METHOD: Sixty-five chest helical CT studies were reviewed. Six radiologists searched for 40 lung nodules on CT images presented in three formats. Film-based viewing of images at 10 and 5 mm increments was performed with a light box. Video viewing of the same examinations was performed in 5 mm increments at 2 frames/s. The area under the receiver operating characteristic curve (Az) measured the observer's ability to detect nodules. RESULTS: The Az was 0.948 for the video viewing, 0.844 for 5 mm increment film-based viewing, and 0.879 for 10 mm increment film-based viewing. There were no statistically significant differences. CONCLUSION: Lung nodules can be detected with similar detection rates when viewing conventional film or videotaped helical CT images. Videotaped images incur a lower cost, an important consideration in mass screening for lung cancer.

Adenocarcinoma↗
PubMedDate not supplied

Effects of L-carnitine supplementation on cardiac morbidity in hemodialyzed patients.

Cardiac diseases are well known among patients on maintenance hemodialysis (HD), and carnitine deficiency may be an important factor in cardiac morbidity. We studied the effects of low-dose L-carnitine treatment (500 mg/day) on chest symptoms (dyspnea on exertion, chest pain, palpitation), cardiac function, and left ventricular (LV) mass in 9 HD patients with reduced ejection fraction (EF). After 6 months of L-carnitine treatment, most patients had at least some improvement in chest symptoms, while LVEF was increased and LV mass was decreased. Carnitine fractions increased and reached plateaus at 2-3 times the baseline levels. These results suggest that prolonged low-dose L-carnitine treatment can improve the cardiac morbidity by restoring decreased carnitine tissue levels and impaired oxidation of FFA.

Administration, Oral↗