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Biomedical subjects

M Târlea

Publications and source records attributed to M Târlea.

8 recordsLinked to original sources
PubMedDate not supplied

Temporal discrepancies between low and high frequency vibrations of the second heart sound.

The morphologic analysis of the second heart sound may provide some useful informations, not enough debated in the literature, concerning the functional status of cardiac patients. We noticed significant temporal discrepancies on the phonocardiographic tracings between the onset of the second heart sound in the lowest and in the highest frequency ranges. The correlations between the highest and the lowest frequency vibrations of the second heart sound were analysed in 119 controls, without overt cardiovascular disease, aged from 20 to 40 years and 50 to 70 years and in 148 patients with old myocardial infarction aged 42 to 80 years. The lowest frequency vibrations of the second heart sound appeared earlier in healthy young subjects than in middle-aged people. These differences may be explained by the reduced aortic compliance with advanced age. The incidence of early beginning of the low frequency vibrations of the second heart sound is greater in patients with old myocardial infarction and a poor myocardial contractile condition than in controls of about the same age. This difference may be due to impaired ventricular relaxation.

Adult↗
PubMedDate not supplied

Asymptomatic electrocardiographic ischemia and silent myocardial ischemia.

Silent myocardial ischemia is undoubtedly the second most prevalent cardiovascular disease after arterial hypertension. Considering its statistical and social importance, the authors, while admitting the less specific coronary character of this entity, do not agree with its being omitted from the last classification of coronary disease (1979), in which especially/angina pectoris and myocardial infarction are emphasized. In the present paper, which opens up an investigation into initially silent ischemia carried out on a great number of cases, the authors discuss the preliminary observations derived from a ten-year (1976-1986) follow up of 56 cases of initially asymptomatic electrocardiographic ischemia with an electric localization suggesting specific coronary territories. It results that the incidence of an unfavourable evolution (myocardial infarction, angina pectoris, onset of arrhythmias or conduction defects) is somewhat higher in males than in females, but not up to 3-4 times as stated in most populational studies on myocardial infarction. The electrocardiographic and clinical improvements are, however, definitely more frequent (4 times) in women than in men (p less than 0.002). Of the 56 cases studied, 26.6% worsened, 23.2% improved, and 21.5% presented no change along the 10 years of follow up (the others showed electrocardiographic evolutions without a clinical expression, while 2 died from a noncardiac cause.

Adult↗
PubMedDate not supplied

Painless myocardial ischemia and atherosclerous valvulopathies--their great statistical prevalence.

3384 patients over 40 years old referred to our Cardiovascular Laboratory for overt cardiovascular complaints were examined by usual non-invasive investigations. Painless myocardial ischemia (PMI) prevalence was 17.49% and degenerative aortic and mitral valvulopathies incidence was 15.60%. PMI predominate in women especially in the group 50-59 years of age in which painful forms of ischemic heart disease have the highest prevalence in men. Although more affected by painless myocardial ischemia, women show a more favourable outcome than men. Ischemic heart disease was frequently associated with isolated mitral regurgitation. In the elderly patients mitral valvulopathy was associated with calcific aortic stenosis. No significant difference was noted between mitral and aortic valvulopathies prevalence.

Adult↗
PubMedDate not supplied

QT alterations and cardiodynamic parameters in old myocardial infarction.

Prolonged QT interval in patients with old myocardial infarction was noticed as a marker of poor prognosis. The sensitivity of this functional electrocardiographic scar was augmented in 82 patients with old myocardial infarction by recording the recumbent and orthostatic electrocardiogram, phonocardiogram and carotid piezogram. The incidence of abnormally prolonged QT intervals and increased QT ratios was three times higher in orthostatic posture than in patients lying down. Abnormal QT intervals in standing position correlate also with abnormal PEP/L VET ratio and severe electrocardiographic alterations and may become a useful tool for a more accurate prognosis in patients with old myocardial infarction.

Aged↗
PubMedDate not supplied

Phonocardiographic changes induced by neuropsychic stress.

We studied the changes occurred in the electrocardiograms, phonocardiograms, apexocardiograms, carotid pulse tracings and blood pressure in 21 healthy men, range 18 to 45, before and during performing timed mental arithmetics. Besides well-known significant increase in heart rate, systolic blood pressure, differential blood pressure (no significant rise in diastolic blood pressure was observed) several phonocardiographic abnormalities were recorded: a significant increase in amplitude and number of vibrations of the early systolic ejection sound and a prominent fourth sound. In general the preexistent third sound diminished after mental stress. In young subjects--range 18 to 30--the ratio of preejection period versus ejection period was lower after mental stress as hyperkinetic conditions occurred whilst in adults the ejection period shortened. The detected phonocardiographic abnormalities reflected significant changes in contractility and compliance of myocardium and great vessels. These abnormalities may account for some cardiac dysfunction in patients with ischemic heart disease subjected to neuropsychic stress and may be misinterpreted for more severe pathological changes.

Adolescent↗
PubMedDate not supplied

Sympathetic hyperfunction syndrome.

Vegetative troubles induced by sympathetic hyperfunction are presented and an attempt is made to systematize them. Functional tachycardia or premature beats in neurocirculatory asthenia, symptoms of sympathetic irritation in cervical radicular syndrome, hyperkinetic syndrome with positive exercise test, long Q--T syndrome, the classic troubles of sympathetic origin in pheochromocytoma and "the vegetative storm" in cerebral damages or excessively stressful situations may be included in the sympathetic hyperfunction syndrome. Of greater clinical interest is the cervical radicular syndrome with sympathetic irritation, which is presented in details, with reappraisal of some morphofunctional data that must be taken into account in clinical reasoning.

Angina Pectoris, Variant↗
PubMedDate not supplied

Cardiodynamic and electrocardiographic alterations induced by blood sampling in normal and hypertensive donors.

The 12 routine electrocardiographic leads, apical phonocardiogram, piezocarotidogram, Korotkov blood pressure, sitting and standing, were recorded before and after 500 cc blood sampling in 20 hypertensive donors and 20 normals. The cardiodynamic (systolic time intervals) disturbances in hypertensive donors were more frequent and more persistent than those observed in the normotensive group, despite the favourable effect of the blood sampling on the blood pressure values. The most significant cardiodynamic alteration was the increase in the pre-ejection period/left ventricular ejection time--indicating a more reduced ejection fraction in the hypertensive group and pointing out that the improvement of left ventricular work by decreasing the blood pressure after blood sampling is less important than the hypoxic effect of blood loss.

Blood Donors↗