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Biomedical subjects

M T Wallace

Publications and source records attributed to M T Wallace.

26 records · Page 2Linked to original sources
PubMed1993

Converging influences from visual, auditory, and somatosensory cortices onto output neurons of the superior colliculus.

1. Physiological methods were used to examine the pattern of inputs from different sensory cortices onto individual superior colliculus neurons. 2. Visual, auditory, and somatosensory influences from anterior ectosylvian sulcus (AES) and visual influences from lateral suprasylvian (LS) cortex were found to converge onto individual multisensory neurons in the cat superior colliculus. An excellent topographic relationship was found between the different sensory cortices and their target neurons in the superior colliculus. 3. Corticotectal inputs were derived solely from unimodal neurons. Multisensory neurons in AES and LS were not antidromically activated from the superior colliculus. 4. Orthodromic and antidromic latencies were consistent with monosynaptic corticotectal inputs arising from LS and the three subdivisions of AES (SIV, Field AES, and AEV). 5. Superior colliculus neurons that received convergent cortical inputs formed a principal component of the tecto-reticulospinal tract. Thus there appears to be extensive cortical control over the output neurons through which the superior colliculus mediates attentive and orientation behaviors. 6. Two other multisensory circuits were identified. A population of multisensory superior colliculus neurons was found, which neither received convergent cortical input nor projected into the tecto-reticulo-spinal tract. In addition, multisensory neurons in AES and LS proved to be independent of the superior colliculus (i.e., they were not corticotectal). While it is likely that these three distinct multisensory neural circuits have different functional roles, their constituent neurons appear to integrate their various sensory inputs in much the same way.

Animals↗
PubMed1992

Integration of multiple sensory modalities in cat cortex.

The results of this study show that the different receptive fields of multisensory neurons in the cortex of the cat anterior ectosylvian sulcus (AES) were in spatial register, and it is this register that determined the manner in which these neurons integrated multiple sensory stimuli. The functional properties of multisensory neurons in AES cortex bore fundamental similarities to those in other cortical and subcortical structures. These constancies in the principles of multisensory integration are likely to provide a basis for spatial coherence in information processing throughout the nervous system.

Animals↗
PubMed1992

Visual, auditory and somatosensory convergence in output neurons of the cat superior colliculus: multisensory properties of the tecto-reticulo-spinal projection.

A select population of superior colliculus (SC) neurons receives and integrates information from the visual, auditory and somatosensory systems. Determining which SC neurons comprise this population and where they send their multisensory messages is important in understanding the functional impact of the SC on attentive and orientation behavior. One of the major routes by which the SC influences these behaviors is the tecto-reticulo-spinal tract, a descending pathway that plays an integral role in the orientation of the eyes, ears and head. Of the 182 tecto-reticulo-spinal neurons (TRSNs) encountered in the present study, almost all (94%) responded to sensory stimuli and the overwhelming majority (84%) were multisensory. The present results demonstrate that the TRSN serves as an important link among the different sensory systems and provides a substrate through which they may gain access to the circuitry mediating orientation behavior.

Acoustic Stimulation↗
PubMed1991

Behavioral and physiological consequences of unilateral ablation of the nucleus isthmi in the leopard frog.

Unilateral lesions of the nucleus isthmi result in a scotoma to visually presented prey and threat stimuli in the contralateral monocular visual field. There is a correlation between the size of the scotoma and the amount of n. isthmi ablated. Following the lesion, there is a regression of the scotoma in the nasal part of the visual field which then stabilizes. Upon longer behavioral examination, the animals can be divided into two classes: (1) animals in which the scotoma remains relatively stable in size for up to two years, and (2) animals which recover from the scotoma. In the latter group, there tends to be damage to both the n. isthmi and the posterodorsal tegmental nucleus which lies mediocaudal to the n. isthmi. Electrophysiological recording from positions within the area of the optic tectum representing the scotoma reveal an average threefold increase in the size of the multiunit receptive fields compared to mirror image positions in the contralateral optic tectum.

Animals↗
PubMed1990

Nucleus isthmi: its contribution to tectal acetylcholinesterase and choline acetyltransferase in the frog Rana pipiens.

The distribution of acetylcholinesterase and the activity of choline acetyltransferase was studied in the tecta of normal frogs and frogs without retinal and/or nucleus (n.) isthmi inputs. In normal animals acetylcholinesterase activity is found primarily in three bands in the outer layers of the tectum-lamina A, laminae C-F, and lamina G. After retinal and contralateral n. isthmi deafferentation three distinct bands of tectal acetylcholinesterase activity are still present. After bilateral n. isthmi deafferentation there is loss of activity in lamina G and reduced activity in lamina A. With retinal and ipsilateral n. isthmi deafferentation, activity is seen only in lamina A. With retinal and bilateral n. isthmi deafferentation there is virtually no acetylcholinesterase activity in the outer tectal layers. Following unilateral retinal deafferentation there is no statistically significant difference in choline acetyltransferase specific activity between intact and deafferented tectal lobes after two, four and nine weeks. With unilateral nucleus isthmi lesions and survival times of between 10 and 40 days, choline acetyltransferase specific activity in the tectal lobe ipsilateral to the ablation is approximately 38% of the specific activity of the contralateral lobe. With bilateral n. isthmi lesions there is a strong correlation between amount of n. isthmi ablated and reduction of choline acetyltransferase activity. In vitro tectal acetylcholine synthesis was also determined in animals with unilateral n. isthmi ablation. On average, tectal lobes ipsilateral to the ablated n. isthmi synthesize acetylcholine at a rate which is approximately 58% of that of contralateral tecta. Collectively, these results imply that n. isthmi is the sole cholinergic input to the frog optic tectum, with ipsilaterally projecting isthmotectal fibers accounting for the greater share.

Acetylcholine↗
PubMed1989

Relationship between isthmotectal fibers and other tectopetal systems in the leopard frog.

We studied the relationship of isthmotectal input to other tectal afferent fiber systems in three ways. 1) Using horseradish peroxidase (HRP) histochemistry, we determined the nonretinal inputs to the superficial tectum. In different sets of animals we a) applied HRP to the tectal surface; b) inserted HRP crystals into the tectum; c) injected small volumes of HRP solutions into the superficial tectum. N. isthmi accounts for more than 65% of the nonretinal extrinsic input in the superficial tectal layers. One set of fibers from the contralateral n. isthmi projects to the most superficial layer. Fibers from posterior thalamus and tegmentum project to both superficial and deeper layers in the tectum, but not to the most superficial layer. The ipsilaterally projecting isthmotectal fibers terminate in the deeper superficial layers. 2) We investigated the relationship between retinofugal and contralaterally projecting isthmotectal pathways. We orthogradely labelled n. isthmi fibers by unilateral HRP injections into n. isthmi, and we also labelled retinal fibers by injecting tritiated l-proline into both eyes. In such animals contralaterally projecting isthmotectal fibers cross in the dorsal posterior region of the optic chiasm. From the chiasm to the tectum isthmotectal fibers and retinofugal fibers are admixed. 3) We determined whether other fiber systems cross with contralaterally projecting isthmotectal fibers. We cut the posterior part of the optic chiasm and applied HRP crystals to the cut. Only n. isthmi and retina are retrogradely labelled.

Animals↗