Search PubMed⌕ Search

Biomedical subjects

M T Pheils

Publications and source records attributed to M T Pheils.

At least 37 records · Page 2Linked to original sources
PubMed1982

Diverticular disease: a retrospective study of surgical management 1970-1980.

At Concord Hospital during the period 1970-1980, there were 2,530 admissions for diverticular disease. One hundred and twenty nine patients required operative treatment, 80 patients had a 'planned' resection and of the 56 patients admitted with peritonitis, 49 came to operation. The hospital mortality following resection was 7.5% and following operation for peritonitis was 14%. The morbidity after planned resection was 36% and after operation for peritonitis was 51%. Measures adopted to improve these results are discussed.

Diverticulum, Colon↗
PubMed1981

The relationship of survival to staging and grading of colorectal carcinoma: a prospective study of 503 cases.

A clinicopathologic staging method for colorectal carcinoma was applied prospectively to 503 patients treated by surgical resection over a period of 7 1/2 years. The method grouped separately those patients known to be incurable at the time of resection and allowed for an anatomically precise definition of the extent of tumor spread. Survival studies showed that prognosis did not significantly deteriorate with spread of tumor beyond the bowel wall unless there were demonstrable metastases, infiltration of a free serosal surface, or if local resection was incomplete. Highly significant decrements in survival occurred when lymph node metastases were demonstrable and when unresected tumor was known to be present. The staging system from which these observations were made formed an improved guide to prognosis when compared with the original Dukes' method. Patients with histologically high-grade tumors had a poorer survival rate than those with low or average tumors with the same extent of spread.

Adenocarcinoma↗
PubMed1981

The effect of fluorouracil on survival in metastatic colorectal cancer fluorouracil response improves survival.

We set out to define the place for therapy with fluorouracil in patients with advanced colorectal cancer. Sixty-three patients with stage D2 cancers were observed for seventeen months to five years from the time of diagnosis. Thirty patients received fluorouracil in various regimens. Nineteen patients were not referred for chemotherapy, a further eleven were excluded because their condition was terminal, and three could be evaluated. Ten patients had either partial or complete response to fluorouracil; their median survival was 25 months. Twenty patients who did not respond to fluorouracil had a median survival of 11 months, whereas the non-treated group had a median survival of 15 months. The difference between the responders and the other groups was highly significant.

Clinical Trials as Topic↗
PubMed1981

The distribution of colorectal carcinoma and the relationship of tumour site to the survival of patients following resection.

A review of 532 patients undergoing elective resection for colorectal carcinoma between January 1971 and December 1978 showed no significant trend in the proportion of right colon carcinomas resected during this time. There was a higher proportion of advanced-stage tumours in the right colon than in the rectum. Patients with carcinoma of the right colon had a significantly poorer survival than did patients with rectal carcinoma.

Aged↗
PubMed1981

Experiments in the development of a continent ileostomy: a simplified technique without a reservoir in dogs.

A continent ileostomy without a reservoir was constructed in five dogs with minimal morbidity and mortality rates. The technique involved constructing a continent valve by retrograde intussusception of 8 cm of the terminal ileum, which was then exteriorized as an end ileostomy. The terminal ileum was emptied every 2 hours in the first week, 4 hours in the second week, 6 hours in the third week, and every 8 hours thereafter. This allowed it to gradually dilate and form its own natural reservoir. The follow-up period was 3 to 7 months. The animals remained fully continent to gas and feces. The reservoir capacity after 2 months was 600 cc. No pressure changes within the reservoir were observed with continuous infusion of saline solution.

Animals↗
PubMed1980

Sigmoidoscopic reduction of sigmoid volvulus.

Twenty-six patients were treated for a volvulus of the sigmoid colon between January, 1971, and June, 1979. Eight patients had an emergency resection and, although there was a high postoperative morbidity, there were no deaths in this group. An attempt to decompress the volvulus by means of a rigid sigmoidoscope was made in 18 patients. This was successful in 14 patients. Six of these patients suffered a recurrence, and perforation occurred in four patients, three of whom subsequently died. Because of the high risk of perforation, care should be taken with this procedure.

Aged↗
PubMed1980

Organoaxial volvulus of the stomach and volvulus of the sigmoid colon.

The management of a patient in whom both organoaxial volvulus of the stomach and volvulus of the sigmoid colon had occurred is described. Anterior gastropexy was successful in preventing recurrence of the gastric volvulus. The angulation and distortion of the stomach so produced may have been responsible for the development of a benign gastric ulcer.

Humans↗
PubMed1980

Preoiperative carcinoembryonic antigen level and prognosis in colorectal cancer.

Carcinoembryonic antigen (CEA) levels were estimated in 117 patients before resection of colorectal cancer. Twenty-six per cent of patients had normal CEA values. CEA values rose progressively with tumour stages, and were higher in patients with liver metastases compared with patients with only lymph-node spread. No significant difference in survival, independent of stage of spread, was found between patients with preoperative levels of antigen greater or less than 5 ng/mL of plasma. Similarly, there was no significant difference between the survival of patients with stage B or stage C tumours regardless of whether their levels of the antigen were greater or less than 10 ng/mL of plasma. A single preoperative CEA estimation does not add to the prognostic information available from careful assessment of the stage of tumour spread.

Aged↗
PubMed1980

Screening of patients after surgery for colorectal carcinoma: value of faecal occult blood testing and flexible sigmoidoscopy.

Sixty asymptomatic patients aged less than 65 years, who had survived for more than two years after resection for colorectal carcinoma were tested for faecal occult blood loss using Hemoccult-II (six slides). In 55 patients, a double-contrast barium-enema X-ray examination was also performed, and 41 patients underwent flexible sigmoidoscopy. In two cases a positive Hemoccult result was obtained and no colonic lesion was found in one of these patients. Six patients who gave a negative Hemoccult result were found to have adenomatous polyps. Faecal occult blood testing is unsatisfactory for detection of polyps. Flexible sigmoidoscopy is a rapid and safe examination and complements radiology in the screening of patients.

Colonic Neoplasms↗