Biomedical subjects

M T Madsen

Publications and source records attributed to M T Madsen.

45 records · Page 3Linked to original sources

PubMed1985

Technetium-99m pyrophosphate scintigraphy for the detection of acute myocardial infarction. How useful is it?

To evaluate the contribution of Tc-99m pyrophosphate scintigraphy (TPS) on the overall management of patients suspected of having acute myocardial infarction (AMI), hospital records of 58 consecutive patients who underwent TPS, were evaluated in depth. The results indicate that TPS was essential for the diagnosis of AMI in 16% of the patients. TPS was most rewarding in perioperative patients and in patients with borderline or uninterpretable electrocardiographic and enzyme changes. Also, in some cases, TPS was able to confirm or exclude the diagnosis of AMI prior to the confirmation by serial electrocardiograms (ECG) and serial enzyme changes. TPS was less rewarding in patients with clinically low index of suspicion for AMI. It may also be confusing in patients with high clinical likelihood of AMI and a history of prior myocardial infarction because of the possibility of persistently positive TPS in some of these patients. Considering the limitations of ECGs, the cardiac enzymes, and atypical clinical presentations in the patient population we evaluated, TPS appears to be fairly accurate when the scintigraphic findings are compared with the final diagnosis at the time of discharge from the hospital.

Aged↗

PubMed1985

Enhancement of SPECT images by Fourier filtering the projection image set.

Tomographic images from rotating gamma camera systems are often difficult to interpret because of poor contrast and high noise levels. A method is presented for improving the quality of these images by Fourier filtering the projection image set prior to reconstruction. A two-dimensional circularly symmetric Gaussian function is used as the spatial frequency filter. This filter can be optimized to enhance contrast and suppress noise in the projection image set in a straightforward and simple manner from the power spectra of representative projections. Preprocessing of the projections makes it possible to use a ramp reconstruction filter. The resulting tomographic sections show a dramatic improvement in image quality.

Bone and Bones↗

PubMed1984

Neutrophil labeling: problems and pitfalls.

The use of neutrophils labeled with gamma-emitting radionuclides has been shown to be acceptable for in vivo kinetic studies as well as for imaging inflammatory foci. Among the gamma-emitting radionuclides, indium-111 appears to be the agent of choice. Labeling neutrophils with 111In, however, is a relatively new technique. Although simple to perform, it involves several stages, none of which could be carried out without problems. These are discussed and the current research aimed at eliminating the problems is outlined. The knowledge of specific chemotactic receptors and surface antigens has stimulated investigations into selective neutrophil labeling that will continue to be challenging and exciting.

Animals↗

PubMed1983

Abnormal thallium-201 scans in patients with chest pain and angiographically normal coronary arteries.

We reviewed the exercise thallium-201 (TI-201) scans and clinical data of 41 patients with chest pain and normal coronary arteries to identify clinical factors associated with "false-positive" studies. Exercise TI-201 studies were performed before angiography and often precipitated referral. Sex, beta-blocker therapy, anginal pattern, and results of exercise electrocardiography were evaluated and compared with TI-201 imaging. A negative TI-201 study was the most common finding (p less than 0.005). Of the 41 patients, 11 (27%) had abnormal exercise TI-201 scans. No clinical factor was significantly associated with a false-positive TI-201 scans. Of the 11 patients with abnormal scans, 9 had greater than or equal to 1 cardiac abnormality: right bundle branch block in 2, mitral valve prolapse in 3, paroxysmal atrial fibrillation in 2, abnormal left ventricular diastolic pressure in 3, and left bundle branch block in 1. Thus, (1) when results of exercise TI-201 imaging are used to refer patients for angiography, "false-positive" TI-201 studies are common; (2) sex, beta blockade, anginal pattern, and results of exercise electrocardiogram are not useful predictors of a false-positive TI-201 study; and (3) patients with chest pain, normal coronary arteries, and abnormal TI-201 scans frequently have other cardiac abnormalities.

Coronary Disease↗

PubMed1981

An investigation of 11C-methane, 13N-nitrous oxide and 11C-acetylene as regional cerebral blood flow agents.

Radioisotopes of xenon or krypton are generally used as the inert diffusible indicators in regional cerebral blood flow (rCBF) studies. These gases have disadvantages when introduced into the body inhalation because of their low solubility in body tissues. The use of 11C-methane, 13N-nitrous oxide and 11C-acetylene as inhalation rCBF agents has been investigated. These gases span a wide range of solubilities: methane is four times less soluble than xenon in body tissues while nitrous oxide and acetylene are respectively 3 and 6 times more soluble. Cerebral blood flow measurements were performed on normal volunteers using the three labelled gases as well as 133Xe. All tracers were administered by inhalation and the cerebral clearance of the gases was monitored by coincidence detection. Uptake in the body was found to be dependent on solubility. The computed blood flow values found using the various indicators were in excellent agreement and were within the normal cerebral blood flow range. The high solubilities of acetylene and nitrous oxide result in a more efficient transfer of tracer from lung to brain than the conventionally used agents. The positron emission is also advantageous for tomographic rCBF measurements.

Acetylene↗

PubMedDate not supplied

Emission-based attenuation correction of myocardial perfusion studies.

BACKGROUND: Nonuniform attenuation in the thorax can generate artifacts in single-photon emission computed tomographic myocardial perfusion studies that mimic coronary artery disease. In this article we present both phantom and simulation data, as well as clinical data, in support of an emission-based method that provides reliable correction for attenuation effects without the need for a transmission measurement. METHODS AND RESULTS: The attenuation map is derived from the measured distribution of 99mTc-labeled macroaggregated albumin in the lungs and a radioactive binder wrapped about the thorax. This information is acquired as part of a dual-isotope acquisition during the rest 201Tl study. Segmentation is used to define the interiors of lung and body compartments, which are assigned a single attenuation coefficient for each of the two tissue types. The appropriateness of this approach was investigated by examining the measured attenuation coefficients in a group of 80 individuals (40 male, 40 female) from positron emission tomographic transmission studies. The correction technique was evaluated with computer simulations, a physical phantom, and clinical data acquired from 20 patients. Analysis of the positron emission tomographic data found a small SD in the mean attenuation coefficients for the body (<5%) and lungs (<15%). The application of emission-based attenuation-correction technique produced a substantial reduction in the magnitude of the attenuation artifact in images obtained from both the phantom and the simulation studies. The emission-based attenuation-correction technique was easily applied to myocardial perfusion studies, where it had a significant effect, resulting in changes in interpretation for nine of 20 patients. CONCLUSIONS: The results of this study provide strong support for the concept that an attenuation map can be generated with fixed attenuation values in place of those that are directly measured. Thus the emission-based attenuation-correction technique can be considered an inexpensive alternative to transmission-based correction methods. Because the emission-based correction technique does not require any additional hardware, it has the major advantage of being applicable to all single-photon emission computed tomographic systems.

Adult↗

PubMedDate not supplied

A precise method for correcting count-rate losses in scintillation cameras.

Quantitative studies performed with scintillation detectors often require corrections for lost data because of the finite resolving time of the detector. Methods that monitor losses by means of a reference source or pulser have unacceptably large statistical fluctuations associated with their correction factors. Analytic methods that model the detector as a paralyzable system require an accurate estimate of the system resolving time. Because the apparent resolving time depends on many variables, including the window setting, source distribution, and the amount of scattering material, significant errors can be introduced by relying on a resolving time obtained from phantom measurements. These problems can be overcome by curve-fitting the data from a reference source to a paralyzable model in which the true total count rate in the selected window is estimated from the observed total rate. The resolving time becomes a free parameter in this method which is optimized to provide the best fit to the observed reference data. The fitted curve has the inherent accuracy of the reference source method with the precision associated with the observed total image count rate. Correction factors can be simply calculated from the ratio of the true reference source rate and the fitted curve. As a result, the statistical uncertainty of the data corrected by this method is not significantly increased.

Biometry↗

PubMedDate not supplied

A method for obtaining an approximate Wiener filter.

The Wiener restoration filter yields the minimum mean-square error between the restored image and the true object function. However, it has found limited use because, in its usual formulation, it requires information about the object power spectrum which is generally unknown. In this paper, it is shown that the Wiener filter can be derived from the noise-free image power spectrum, and a method is presented for estimating this from the observed data. From this estimate an approximate Wiener filter was calculated. The method was tested on three sets of simulated data which included a constant background, rectangular defects, and Gaussian defects at varying contrast and noise levels. The performance of the approximate Wiener filter was compared both to the true Wiener filter and to the standard 1-2-1 three-point smooth. The results confirmed that the approximate Wiener filter adapted to the information content of the observed data and closely matched the performance of the true Wiener filter. The approximate Wiener filter outperformed the three-point smooth in all cases, especially at low contrast and high noise levels. The approximate Wiener filter can be calculated without operator intervention and requires little additional computation time over conventional Wiener filter techniques.

Filtration↗

PubMedDate not supplied

A device for applying static loads to prosthetic limbs of transtibial amputees during spiral CT examination.

This paper describes a device that allows the imaging of prosthetic legs under load conditions using spiral computerized tomography (CT). The device consists of a chair and a vertical footplate mounted on a 17.8 x 1.9 cm oak board that is 197 cm long. The load device can be easily positioned onto the CT bed. A subject sits in the chair and applies force by pushing the foot portion of the prosthesis against the footplate. The magnitude of the force is monitored by a digital force gauge coupled to the footplate. Because the load is borne by the hips and lower back of the subject against the chair, substantial forces can be generated and steadily maintained for the 20-45 s duration of the CT study. This device has been used successfully with 19 transtibial amputees, allowing the acquisition of spiral CT studies with half and full body weight loads.

Amputation, Surgical↗