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Biomedical subjects

M T Hsieh

Publications and source records attributed to M T Hsieh.

46 records · Page 3Linked to original sources
PubMed1986

Hemodynamic effects of "san-huang-hsieh-hsin-tang" in patients with essential hypertension.

The ancient Chinese formula of "San-Huang-Hsieh-Hsin-Tang" (S-T) was originally used for patients with "epigastric fullness, flushing, restlessness, constipation and a hard pulse" (Chang 115 B.C.). All these symptoms are frequently observed in patients with essential hypertension. We assessed the antihypertensive and hemodynamic effects of this formula, and found that S-T decreased blood pressure, total peripheral resistance, heart rate and cardiac contractile force. S-T had no apparent effects on cardiac output and blood volume.

Adult↗
PubMed1986

Effects of Suanzaorentang on behavior changes and central monoamines.

Previously, it was found that the ancient Chinese remedy of Suanzaorentang could be a promising anxiolytic drug (Chen and Hsieh, 1985a, Chen and Hsieh, 1985b). To understand the mechanism of the action of Suanzaorentang, the effects of Suanzaorentang on behavior changes and central monoamines and their metabolites were studied in rats. It was found that Suanzaorentang significantly (1) prolonged the period from the onset of clonic to tonic convulsions induced by pentylenetetrazol or picrotoxin, (2) prolonged the sleep duration induced by hexobarbital, (3) reduced locomotor activity, (4) enhanced the hypomotility induced by alpha-MT, (5) reduced the locomotor stimulation produced by levodopa plus benserazide, and (6) reduced central HVA, VMA, and 5-HIAA, but had no significant effects on central DA, NA, and 5-HT. These facts implied that Suanzaorentang decreased the turnover rate of central monoamines and central catecholaminergic activity.

Animals↗
PubMed1986

Suanzaorentang versus diazepam: a controlled double-blind study in anxiety.

The ancient Chinese remedy Suanzaorentang was originally described in Kin-Kue-Yao-Lueh for patients with weakness, irritability and insomnia. In our preliminary observations on suanzaorentang, it seemed to be a promising anxiolytic remedy. A controlled comparative double-blind clinical trial was set up to assess the anxiolytic effect of suanzaorentang. Suanzaorentang (250 mg t.i.d.) and diazepam (2 mg t.i.d.) had almost the same anxiolytic effect. However, suanzaorentang, but not diazepam, improved the psychomotor performance during the daytime. No significant subjective side effects were observed during treatment with suanzaorentang. All laboratory tests, including liver function tests (serum SGOT, SGPT, albumin, globulin, bilirubin), renal function tests (BUN, serum creatinine), electrolyte balances (serum K+, Na+, Cl-, Ca++), serum cholesterol-triglyceride-HDL-c, thyroid function test (serum T4), chest P-A X-ray film, blood-urine-stool routine examinations (BUS routines), were unaltered after one week's administration of the compound.

Adult↗
PubMed1986

Suanzaorentang, and anxiolytic Chinese medicine, affects the central adrenergic and serotonergic systems in rats.

Previously, we found that the ancient Chinese remedy of Suanzaorentang was a promising anxiolytic drug (Chen and Hsieh, 1985; Chen and Hsieh, 1985a). We also found that Suanzaorentang decreased the turnover rate of central monoamines and central catecholaminergic activity (Hsieh, et al., 1986). In this study, we found that 5-hydroxytryptophan (5-HTP) induced decrease in locomotor activity was significantly antagonized by Suanzaorentang, p-chlorophenylalanine (p-CPA) induced increase in locomotor activity was significantly inhibited by Suanzaorentang, Suanzaorentang had no significant effects on baclofen, muscimol, aminooxyacetic acid (AOAA) and thiosemicarbazide induced changes in locomotor activity, Suanzaorentang significantly decreased vanillylmandelic acid (VMA) in striatum and hippocampus, homovanillic acid (HVA) in hippocampus and 5-hydroxyindol acetic acid (5-HIAA) in striatum and hypothalamus, Suanzaorentang significantly reversed the alpha-methyltyrosine (alpha-MT) produced decrease in DA concentrations in striatum and hippocampus, and (6) Suanzaorentang significantly reversed the p-CPA produced decrease in 5-HT concentrations on amygdala. These facts implied that Suanzaorentang might decrease the serotonergic activity but have no significant effect on GABAergic activity. The main locus of action might be in the limbic system.

Animals↗
PubMed1985

Studies on the suanzaorentang in the treatment of anxiety.

We studied the anxiolytic and psychomotor effects of the ancient Chinese formula of Suanzaorentang, and found that it improved mood, decreased the accompanying sympathetic symptoms and improved psychomotor performance during the day.

Anti-Anxiety Agents↗
PubMed1985

Clinical trial of suanzaorentang in the treatment of insomnia.

The hypnotic effect of suanzaorentang, an ancient Chinese remedy for insomnia, was studied in 60 patients with sleep disorders. After receiving placebo for one week, patients ingested capsules containing 1 gm of suanzaorentang each night, 30 minutes before bedtime, for two weeks. Treatment was followed by another week of placebo administration. Each morning during the study, patients completed questionnaires relating to their sleep the night before and to their ability to function during the previous day. Analysis of the responses showed statistically significant improvements (P less than 0.001) in all ratings of sleep quality and well-being during active treatment compared with both placebo periods. Laboratory tests performed before and after treatment with suanzaorentang showed no alterations in any test value. No side effects were noted. We conclude from these results that the compound merits further extensive investigation.

Adult↗
PubMed1985

Effects of san-huang-hsieh-hsin-tang on sympathetic activity, plasma renin, and plasma aldosterone.

San-Huang-Hsieh-Hsin-Tang, an ancient Chinese remedy for gastrointestinal disorders, was also found to lower blood pressure. The authors therefore investigated the effects of this substance on sympathetic activity, plasma renin, and plasma aldosterone. Sympathetic activity and plasma renin activity, but not plasma aldosterone levels, were significantly reduced with treatment. The depressed plasma renin activity could be secondary to depressed sympathetic activity. The discrepancy between plasma renin activity and plasma aldosterone levels, which is also found with beta-blockers, could be explained by the following sequence: decreased renin----decreased aldosterone----increased serum potassium----recovery of aldosterone.

Aldosterone↗
PubMed1984

The pharmacological studies in central nervous system on the interaction of Taiwanese Veratri Formosani Rhizoma and Sophorae Radix.

The eighteen opposing drugs were to be recognized as absolute incompatibility of Chinese herbs. Ku-Shen (Sophorae Radix) opposed Li-Lu (Veratri Rhizoma) is one of these incompatible drugs. In this study, we attempted to investigate and identify the interactions of these two drugs in the CNS by means of modern pharmacological technics. The results elucidate that toxicity, number of retching movements, change of locomotor activity and the concentration of monoamines' metabolites of Li-Lu can be changed by Ku-Shen. From these results, further evidence was provided that the involvement of Li-Lu and Ku-Shen in the eighteen opposing drugs of Chinese ancient Pentsao are deemed to be significant.

Animals↗
PubMed1982

The involvement of monoaminergic and GABAergic systems in locomotor inhibition produced by clobazam and diazepam in rats.

The effects of 1,5-benzodiazepine clobazam and diazepam were evaluated with regard to behavioral locomotor changes in rats. A concurrent focus of investigation was whether or not both benzodiazepines interact with central monoaminergic and GABAergic mechanisms. Diazepam was more active than clobazam in reducing locomotor activity. The stimulation of locomotor activity induced by L-dopa plus benserazide, and methamphetamine was significantly counteracted by diazepam but unaffected by clobazam. Hypomotility produced by alpha-methyl-p-tyrosine was markedly augmented with both drugs. Locomotor suppression elicited by 5-HTP, activating central serotoninergic transmission, was more potently reversed by clobazam than by diazepam. In addition, arousal behavior produced by p-CPA, inactivating central serotoninergic transmission, was completely abolished by both drugs. Furthermore, in combination with AOAA, known to inhibit motor activity, diazepam had a synergistic effect, and picrotoxin-produced suppression was significantly antagonized by diazepam. Both benzodiazepines thus may exert their behavioral depressant effects by reducing catecholaminergic and serotoninergic activity, and also by promoting GABA-mediated inhibition in the central nervous system. Clobazam is more effective than diazepam in reducing serotoninergic activity, but less effective in reducing catecholaminergic activity and increasing GABAergic activity.

Animals↗