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M T Daniel

Publications and source records attributed to M T Daniel.

158 records · Page 9Linked to original sources
PubMedDate not supplied

[Acute mast-cell leukemia. Cytochemical and ultrastructural study, about a particular case (author's transl)].

A case of acute Mast-cell leukemia was studied. A 39 years old female presenting with a brief history of abdominal pain and attacks of flushing; peripheral blood and bone marrow contained up to 60% of poorly differentiated blasts with clumping of deep purpule granules. Peroxydase reaction stains were negative, chloroacetate esterase were strongly positive. Toluidine blue revealed metachromatic stain. Histamine content of the cells was highly greater than normal but nos heparinoid activity could be demonstrated. These abnormal mast-cells have been investigated with the electron microscope; only the dense particular type of granule substructure was found, without any lamellae component. The cells were temptatively classified as "immature" mast-cell. The disease was interpretated as an acute leukemic variety of systemic mastocytosis.

Acute Disease↗
PubMedDate not supplied

[Bone lesions in micromegakaryoblastic leukemia].

The authors report four cases of skeletal lesions associated with acute megakaryoblastic leukemia. In this particular form of the disease, the periostal appositions are more frequent and more severe than in other types of acute leukemia. A very marked osteolysis with true metaphyseal lacunar zones are also observed. These particular types of bone lesion are related to the especially widespread cellular proliferation in megakaryoblastic leukemia, and their occurrence implies a very bad prognosis.

Bone and Bones↗