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Biomedical subjects

M Szegedi

Publications and source records attributed to M Szegedi.

9 recordsLinked to original sources
PubMed1995

The detection of gene mutation in transgenic mice (Muta Mouse) following a single oral dose of 2-acetylaminofluorene.

Transgenic mouse assays, such as Muta Mouse, provide a method to predict the potential target organ carcinogenicity of chemical compounds. As part of a validation study, 2-acetylaminofluorene was administered as a single oral dose of either 50 or 100 mg/kg. The mice were killed 3, 7, 14, 28, 56 or 112 days after this single treatment. Mutation frequencies were determined in liver DNA. The results showed that a mutagenic response was observed in the mice treated at the highest dose (100 mg/kg) and this increase was expressed from 28 up to 112 days after the single exposure.

2-Acetylaminofluorene↗