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Biomedical subjects

M Szczepański

Publications and source records attributed to M Szczepański.

At least 19 recordsLinked to original sources
PubMed2001

The lack of effect of a prophylactic dose of enoxaparin on thrombin generation in patients subjected to nephrectomy because of kidney cancer.

It is assumed that major surgery, connected with extensive tissue dissection, brings about the release of tissue factor into circulation and subsequent activation of coagulation system. This activation results in the thrombin generation, which is supposed to be suppressed by the low-molecular-mass heparins (LMMH), administered to the surgical patients as the prophylaxis against postoperative venous thromboembolism. We have estimated the concentration of circulating thrombin-antithrombin (TAT) complex in patients subjected to transperitoneal nephrectomy and randomized into controls and who received 40-mg enoxaparin 12 h before and 12 h after the operation and then once daily for 7 days. We have observed a sharp rise of TAT concentration at the end of surgery and it corresponded to the simultaneous drop of antithrombin (AT) activity. TAT concentration gradually decreased and AT activity increased up to the end of observations on the seventh postoperative day, but there were no differences observed between the groups of patients. We have also observed a biphasic increase of plasmin-plasmin inhibitor (PPI) complex concentration in our patients. Again, there were no differences in PPI between the groups of patients. It is our conclusion that under the conditions of this study, the well-known prophylactic effect of enoxaparin against the venous thromboembolic complications was not mediated by the inhibition of intraoperative thrombin generation. The anti-inflammatory or biophysical influence of LMMH may be rather taken into account in surgical patients receiving prophylactic doses of these heparins.

Adult↗
PubMed1998

Antiphospholipid antibodies and lipoprotein (a) in women with recurrent fetal loss.

OBJECTIVE: To estimate the occurrence of lupus anticoagulant, both isotypes of anticardiolipins, IgG and IgM, and lipoprotein (a) in women with recurrent fetal loss. METHOD: 43 women with two or more fetal losses were included in this open, prospective study. They were divided into a group of 32 nullipara who have had only miscarriages and a group of 11 women who besides the fetal losses were able to give birth to at least one live newborn. Two control groups were also added: 35 women who were never pregnant and 15 parous who did not have any miscarriage. The presence of lupus anticoagulant was assessed by the Staclot LA clotting test. IgG and IgM isotypes of anticardiolipins and lipoprotein (a) were determined using the immunoenzymatic methods. RESULTS: Lupus anticoagulant was discovered in only one of 23 examined patients. Abnormally high values of IgG isotype of anticardiolipins were found in two subjects of each control group and in two nullipara with miscarriages only. The increased level of IgM isotype was noted in approx. 50% of patients with recurrent fetal loss, but at least one successful delivery and in control subjects who were never pregnant. In contrast, the frequency of the increased level of this antibody was diminished by half in the remaining two groups: women who delivered a live child (children) without any miscarriage and women who had only miscarriages. Elevated levels of lipoprotein (a) were found in approx. 30% of non-pregnant control subjects and in the patients of both groups; the abnormally high concentration of this lipoprotein was encountered in only 13% of women who gave birth to live newborn(s) and did not have any miscarriage. CONCLUSION: Of all four determined variables, only abnormally high values of lipoprotein (a) may have some prognostic significance in women predisposed to the recurrent fetal loss.

Abortion, Habitual↗
PubMed1998

Postoperative injection of phenylbutazone does not influence fibrinolytic shutdown.

Twenty-nine patients undergoing cholecystectomy because of chronic calculous cholecystitis were randomised to receive phenylbutazone 10 mg/kg intramuscularly or a control injection (vehicle-containing local anaesthetic) immediately after completion of surgery. Fibrinogen and plasminogen concentrations in plasma, plasminogen activator inhibitor activity in plasma and fibrinolytic activity in concentrated euglobulins were determined before surgery and on the first, third and seventh postoperative days. Phenylbutazone delayed the postoperative rise of fibrinogen concentration and reduced the plasminogen level on the first day after surgery. Fibrinolytic activity in euglobulins was decreased after the operation in both groups. The great dispersion of the results of plasminogen activator inhibitor activity was the plausible cause of the lack of any significant difference in this variable. The postoperative fibrinolytic shutdown, reflected by the decrease of fibrinolytic activity, was unaffected by phenylbutazone. It can be speculated, however, that the decline of plasminogen concentration after surgery in patients receiving this drug was the result of its stimulatory influence on the conversion of plasminogen into plasmin.

Anti-Inflammatory Agents, Non-Steroidal↗
PubMed1996

[The analysis of causes that intensify skin clinical symptoms in patients with food allergy].

The aim of the study was to assess the effect of food, respiratory and contact allergens, infections, vaccinations, stress and other factors that exacerbate skin symptoms in 50 children diagnosed with food allergy. Individual daily cards of observation were used in the analysis. The dominant factors were found to be food allergens (72%, 36 persons) an elimination diet is thus appears to be the main canon of therapy of atopic dermatitis in children.

Allergens↗
PubMed1995

Analysis of causes which intensify the skin symptoms in food allergy.

The aim of the study was the analysis of food allergens, inhalatory allergens, infections, stress, vaccination and others, which exacerbate the skin symptoms in patients with a diagnosis of food allergy. Individual daily observation cards were used in the analysis. The conclusion made was as follows: the dominant factors are food allergens, so an elimination diet is the basic therapy.

Child↗
PubMed1995

Allergic factors as the probable causes of erythrocyturia in children.

The frequency of erythrocyturia in children with diagnosed food allergy was evaluated. The analysed clinical and immunological allergic process indicators and one year's observation confirm the allergic background of erythrocyturia in 2.6% of the examined group. There are indications for an elimination diet and the application of anti-allergic treatment in the above cases.

Adolescent↗
PubMed1995

The level of interleukine-2 (IL-2) in blood serum in children with food sensitive atopic dermatitis.

The level of interleukin-2 (IL-2) in the blood serum in 28 patients with different degree of skin lesions severity of food sensitive atopic dermatitis (AD), was studied. The level of interleukin-2 in the serum from patients with AD was significantly higher than those of healthy children, especially in patients with severe type of eczematous lesions. These results suggest that the increased IL-2 production in food sensitive atopic dermatitis can be very important factor in pathogenesis of skin lesions.

Child↗
PubMed1988

Procoagulant activity of gastric, colorectal, and renal cancer is factor VII-dependent.

The PA of GC, CC, and RC extracts was assayed by the recalcification of human normal or F VII-DP, and the PA of normal tissue was also determined. The PA of normal tissue was higher than that of the cancer tissues in all groups of specimens. Substitution of normal plasma by F VII-DP resulted in significant depression of the PA and the differences in the PA between the normal and cancer tissue samples disappeared. Preincubation of normal and cancer tissue extracts with the cysteine proteinase inhibitors, mercuric chloride and iodoacetamide, did not affect the PA of these extracts. We conclude that the PA of the investigated cancer extracts is factor VII-dependent and can be related to the presence of tissue factor within cancer tissue.

Blood Coagulation Factors↗