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Biomedical subjects

M Sussman

Publications and source records attributed to M Sussman.

114 records · Page 7Linked to original sources
PubMedDate not supplied

A comparative study of the mannose-resistant and mannose-sensitive haemagglutinins of Escherichia coli isolated from urinary tract infections.

The distribution of mannose-resistant (MRHA) and mannose-sensitive (MSHA) fimbrial haemagglutinins was examined in 482 strains of Escherichia coli isolated from 390 adult women and 45 pregnant mothers with a variety of urinary tract infections (UTI), and from 47 healthy controls. The proportion of MRHA strains was significantly higher in patients with symptomatic UTI (75%) than in women with non-significant bacteriuria (30%, p less than 0.001), pregnant women with asymptomatic UTI (34%, p less than 0.0001) and healthy controls (0%). The proportion of MSHA strains was significantly lower in patients with symptomatic UTI (22%) than in women with non-significant bacteriuria (46%, p less than 0.001) and pregnant women with asymptomatic UTI (52%, p less than 0.01). Only 17% of the strains from healthy controls had MSHA activity. In pregnant women with UTI, whether this was symptomatic or asymptomatic, there was a significant association between infection with MRHA strains of E. coli and a past history of UTI. Thus, in a pregnant woman with an infection and a past history of UTI there is a seven-fold greater chance that this infection is due to an MRHA-bearing organism than in pregnant women without such a history. There was also a significant association between MRHA organisms and symptomatic infection. The risk of symptomatic patients having an infection with an MRHA strain is six times greater than that for a patient with a covert infection.

Adhesiveness↗
PubMedDate not supplied

Enzyme-linked immunosorbent assay for anti-streptococcal protoplast membrane antibodies.

An enzyme-linked immunosorbent assay is described for the quantitative determination of circulating antibodies to streptococcal protoplast membranes (SPM) in human sera. The assay was used to study the prevalence of antibodies to SPM of M types 6 and 12 Streptococcus pyogenes in sera from 55 patients with recent streptococcal infection, and 30 normal individuals without clinical evidence of streptococcal infection. No correlation was found between levels of anti-SPM antibodies and ASO titres. However, in serial serum samples from one patient with uncomplicated streptococcal sore throat, it was possible to demonstrate that the increase in the level of anti-SPM antibody paralleled the rise in ASO titre. The anti-SPM antibody level and the ASO titre in this patient persisted throughout a six-month period of follow-up.

Adult↗
PubMedDate not supplied

Acute hematogenous osteomyelitis of the epiphysis.

The case of an 11-year-old boy with acute hematogenous epiphyseal osteomyelitis is presented. Previous reported cases of epiphyseal osteomyelitis have been only of the subacute type. This case is presented to emphasize that osteomyelitis can occur in the epiphysis and reinforce the need for early diagnosis.

Acute Disease↗
PubMedDate not supplied

Late hip subluxation in spastic diplegia associated with unrecognized hydrocephalus.

Problematic hip subluxation is uncommon in spastic diplegia. We have identified three cases of late hip subluxation in teenage children with spastic diplegia associated with unrecognized hydrocephalus or ventriculoperitoneal shunt dysfunction. Each was a community ambulator with radiologically stable hips in childhood, but in adolescence underwent a deterioration in ambulatory status associated with rapid hip subluxation. Subsequent investigation revealed undiagnosed hydrocephalus in one patient and shunt dysfunction requiring revision in the other two. Surgery was performed in all three cases to control the hip subluxation. The atypical presentation of a progressively unstable hip in an ambulatory spastic diplegic patient may indicate the presence of previously unrecognized raised intraventricular pressure.

Adolescent↗