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Biomedical subjects

M Susin

Publications and source records attributed to M Susin.

71 records · Page 4Linked to original sources
PubMed1976

Parasitic lumbar arterial blood supply in renal angiomyolipoma.

A young woman with azotemia was found to have an angiomyolipoma which had parasitic blood supply from a lumbar artery. Parasitic lumbar arterial blood supply from a lumbar artery. Parasitic lumbar arterial blood supply has previously been considered a strong indication of malignancy. Since this benign lesion had not invaded the adjacent retroperitoneal structures, the phenomenon tends to confirm the postulate that parasitic blood supply to a lesion may occur through hypertrophy of small anastomotic channels normally present between adjacent vessels but not normally seen in angiography.

Adult↗
PubMed1976

Renal involvement in patients with hepatosplenic Schistosomiasis mansoni.

In a prospective study of renal involvement in 100 consecutively hospitalized patients with hepatosplenic schistosomiasis mansoni, 15 exhibited persistent proteinuria of varying degree, which in 6 instances was accompanied by hypertension. Nine patients had the nephrotic syndrome. The most common glomerular lesion in this group was membrano-proliferative glomerulonephritis. Surgical biospy obtained during splenectomy in 15 patients without clinical evidence of renal involvement showed glomerular lesions in 6 instances. Focal proliferative glomerulonephritis was the most common lesion in this group. The detection of silent glomerular lesions in patients with Schistosoma mansoni infection suggests that the glomerular alterations may precede clinical manifestations of renal disease.

Adult↗
PubMedDate not supplied

Hybrid form of hairy cell leukemia and chronic lymphocytic leukemia.

We report a case with mixed features of hairy cell leukemia (HCL) and chronic lymphocytic leukemia (CLL), which may represent a hybrid form of these two entities. Hairy projections were demonstrated on leukemic cells in the peripheral blood. Surface marker studies of blood and spleen specimens by flow cytometry and immunohistochemistry showed immunophenotype characteristic of HCL, namely, monoclonal IgG-kappa, positive reactions to CD 11c, CD 19, CD 20, Cd 22, and HLA-DR, but negative reactions to CD 3, CD 5, CD 7 and CD 10. The only atypical finding was the absence of CD 25. Immunogenotyping showed rearrangement of heavy-chain and kappa light chain genes. Leukemic cells were also positive for tartrate-resistant acid phosphatase (TRAP). A pseudosinus pattern was demonstrated in the spleen. However, the leukemic cells in the spleen showed atypical cytologic features. Clinically, the patient had generalized lymphadenopathy, high leukocyte counts, Coombs' negative hemolysis, hypoimmunoglobulinemia and IgG-kappa monoclonal gammopathy, features more consistent with CLL than HCL. Although only CD 11c, CD 22, CD 25 and TRAP are characteristic for HLC and CD 5, characteristic for CLL, a panel of eight markers is recommended for the differential diagnosis of HCL, CLL and other low-grade B-cell neoplasms, which may share some common features, making a clear-cut diagnosis difficult.

Antigens, CD↗
PubMedDate not supplied

Intracardiac teratoma in a child simulating an atrioventricular nodal tumor.

Intracardiac teratoma is an extremely rare pediatric neoplasm. We studied the case of a 6-year-old girl with a right intraventricular cardiac mass. The tumor consisted of clusters of monotonous round epithelial cells scattered in a dense fibrotic stroma and was thought to represent an atrioventricular nodal tumor. Three years later the tumor recurred, with multiple mature elements derived from all three germ layers, and was diagnosed as mature cystic teratoma. Still present, however, were multiple areas that were histologically similar to the earlier lesion. Immunostaining revealed strong positivity for insulin, glucagon, somatostatin, and chromogranin consistent with overgrown pancreatic islets of Langerhans within a mature teratoma.

Atrioventricular Node↗
PubMedDate not supplied

A practical approach to immunophenotyping of lymphomas. Comparison of immunohistologic and immunocytologic techniques.

Comparison of immunohistologic (IH) and immunocytologic (IC) techniques was conducted on 86 specimens. Forty-seven B-cell, five T-cell, and two null-cell lymphomas were identified by IH as well as 16 cases of lymphoid hyperplasia. The results of IC were generally identical to those of IH except for two T-cell and two B-cell lymphomas. The diagnosis of T-cell lymphoma was a major problem for IC because of the presence of normal T-cell count and/or normal helper/suppressor ratio in these cases. Twenty-one percent of the B-cell lymphomas failed to express surface immunoglobulin but did express B1 and HLA-DR antigens. Such a discrepancy was not demonstrated in cases of lymphoid hyperplasia, thus serving as a useful criterion in the diagnosis of B-cell lymphoma. While combined IH and IC should be used for immunophenotyping in large medical centers, IH is recommended for community hospitals. The identification of kappa, lambda, B1 and T11 (Leu 5) antigens in frozen sections with the immunoperoxidase technique should be sufficient to phenotype most lymphoproliferative diseases. The criteria for immunophenotyping of lymphomas are discussed.

Antibodies, Monoclonal↗
PubMedDate not supplied

Rapid onset of co-trimoxazole induced interstitial nephritis.

An infant developed anuric renal failure within 18 hours of starting therapy with Co-trimoxazole for otitis media. There was no prior exposure to Co-trimoxazole, sulfonamides or trimethoprim. A renal biopsy revealed acute interstitial nephritis with eosinophilic infiltration (AIN). The lymphocyte blast transformation test revealed increased proliferation of the patient's lymphocytes on exposure to Co-trimoxazole (Bactrim). Both parents have clinically demonstrated hypersensitivity to sulfonamides. The extremely short latent period between ingestion of the offending drug and the onset of AIN in the absence of prior exposure to the drug has been reported previously. It suggests that drug induced AIN may develop more rapidly in patients with a strong genetic hypersensitivity to the drug.

Anti-Infective Agents↗
PubMedDate not supplied

Medullary thyroid carcinoma metastatic to breast masquerading as infiltrating lobular carcinoma.

Metastatic tumors to the breast from an extramammary site are rare entities and may present diagnostic difficulties for the surgical pathologist because of frequent histological similarities to primary neoplasms in this location. A case is reported of medullary thyroid carcinoma metastatic to the breast in a 28-year-old woman with a family history of MEN IIA (Sipple's) syndrome. Histological features resembled infiltrating lobular carcinoma and included the so-called "targetoid" and "Indian file" patterns. Immunostaining revealed the true nature of the lesion and was diffusely positive for calcitonin, chromogranin, and carcinoembryonic antigen. Electron microscopy disclosed typical neurosecretory granules confirming the diagnosis. A brief review of the literature and differential diagnosis is also presented.

Adult↗