Biomedical subjects

M Sudo

Publications and source records attributed to M Sudo.

297 records · Page 17Linked to original sources

PubMedDate not supplied

MRI and SPECT in influenzal encephalitis.

Repeated magnetic resonance imaging studies were performed in a 22-month-old boy with influenzal encephalitis. T2-weighted magnetic resonance images disclosed multifocal hyperintense areas in the cortex and subcortical white matter of the left frontal, temporal, parietal, and right frontal lobes. 123I single photon emission computed tomography (SPECT) brain images demonstrated decreased uptake in the same regions. SPECT revealed larger areas of decreased uptake as compared with magnetic resonance imaging. One year after the onset of encephalitis, these brain lesions continue to be observed, although the patient has no apparent neurologic sequelae.

Brain Damage, Chronic↗

PubMedDate not supplied

Lipoma on surface of centroparietal lobes.

A 4-year-old Japanese boy with an intracranial lipoma above the surface of the left centroparietal lobes is reported. Paresthesia occurred in the right lower extremity. This symptom continued for 30 min and recurred several times a day. Three weeks after onset, the paresthesia disappeared spontaneously. Ten months after onset, generalized tonic seizures occurred. Routine cranial computed tomography at onset revealed no remarkable lesion, but subsequently full scans, including the slice at the top of the cerebrum, revealed low-density areas on the surface of the left centroparietal lobes. T1-weighted magnetic resonance imaging revealed a hyperintense area in the same regions. The intensity of these areas was decreased by the fat saturation technique; therefore, an intracranial lipoma at a very rare site was diagnosed.

Brain Neoplasms↗

PubMedDate not supplied

MRI assessment of myelination patterns in high-risk infants.

Magnetic resonance imaging (MRI) was used in high-risk infants to assess the myelination process and its relationship with neurologic outcome. The time period when delayed myelination is best detected by MRI was also studied. MRI was performed in 39 high-risk infants (i.e., preterm infants, infants with respiratory distress syndrome, or with neonatal convulsions and asphyxia). In 10 of 11 infants with normal development, MRI revealed a normal myelination pattern before 2 months of age, and in 11 of 13 infants after 2 months of age. Conversely, in infants with poor outcomes, MRI demonstrated delayed myelination patterns in only 1 of 4 infants before 2 months of age but in 9 of 11 infants after 2 months of age. In patients with poor outcomes, delayed myelination was found more frequently after rather than before 2 months of age. These findings demonstrate that delayed myelination detected by MRI is useful in predicting the neurologic outcome of high-risk infants, especially after 2 months of age.

Brain↗

PubMedDate not supplied

MR imaging of myopathy.

Magnetic resonance imaging was performed in 8 patients with muscle disease and 6 normal controls. High intensity areas of varying dimensions were found in thigh muscles of the patients with progressive muscular dystrophy (PMD) and congenital myopathy. Shortened T1 and prolonged T2 values with disease progression were characteristic. The T1 values were variable and prolonged, T2 values were more characteristic of progressive muscular degeneration. The T1 value may help to detect the early stage of PMD. Magnetic resonance imaging is useful in detecting the muscle lesions in PMD and essential for selection of a biopsy site.

Adolescent↗

PubMedDate not supplied

Neonatal mature teratoma of the sphenoidal sinus: a case report.

Teratoma in the head and neck region is very rare. We treated a child with a mature congenital teratoma that arose from the right sphenoidal sinus. He is doing well after early surgical treatment with endoscopic endonasal resection of the tumor.

Endoscopy↗

PubMedDate not supplied

Magnetic resonance imaging in infantile spasms: effects of hormonal therapy.

Magnetic resonance imaging (MRI) was performed on five patients with infantile spasms who were treated with relatively low doses of adrenocorticotrophic hormone (ACTH) to study the extent of brain shrinkage induced by ACTH therapy. MRI prior to ACTH therapy revealed periventricular hyperintensity (PVH) areas and poor myelination in four patients. In one case, MRI performed 2 days after initiation of ACTH therapy also showed PVH and poor myelination. Brain shrinkage was observed 2 weeks after initiation of ACTH therapy. The most impressive follow-up finding upon MRI was the decrease in PVH found in four patients. The differentiation between myelinated white matter and surrounding cortex became poorer in three cases. Cortical atrophy progressed in all patients but ventricular dilation progressed in only one patient. At the end of ACTH therapy, ventricular dilation progressed in all cases. These findings suggest that loss of water not only from periventricular white matter but also from cortex is the main etiological factor of brain shrinkage induced by ACTH.

Adrenocorticotropic Hormone↗

PubMedDate not supplied

Release of heparin-like substance and histamine from basophilic leucocytes separated by counterflow centrifugation elutriation.

Separation of basophilic granulocytes from peripheral blood was carried out by counterflow centrifugation elutriation using a JE-6B roter. The release of histamine and heparin-like substance from basophilic leucocytes was estimated in healthy and asthmatic subjects. 1. The number of basophils was maximal (0.74 x 10(5] at a flow rate of 4.5 ml/min, and the purity reached a peak (11.8 +/- 2.0%) at a flow rate of 9 ml/min. 2. The content of histamine paralleled the number of basophils in each fraction. 3. The release mechanism of histamine induced by anti-IgE was similar to that of the heparin-like substance. 4. The release of histamine and the heparin-like substance was significantly higher in atopic asthmatics than in non-atopic cases.

Adolescent↗

PubMedDate not supplied

The development of personal computer-based medical consultation system for diagnosis of congenital malformation syndromes using MUMPS.

This paper describes a medical consultation system for diagnosis of congenital malformation syndromes. The system consists of a personal computer, NEC PC-98XL (MS-DOS), using SP-MUMPS for the retrieval of knowledge data, and BASIC for the input/output of image data. This system displays pictorial knowledge and is designed so users can build up the knowledge base, as needed, by adding knowledge from medical literature and records of patients actually treated.

Congenital Abnormalities↗

PubMedDate not supplied

Electroretinogram and visually evoked cortical potential in Tay-Sachs disease: a report of two cases.

The electroretinogram (ERG) and visually evoked cortical potential (VECP) were recorded in two cases of Tay-Sachs disease where diagnosis was well established: 1. ERGs of high amplitude and of normal wave form were recordable with prominent oscillatory potentials. Responses were always equal in both eyes. 2. VECPs were extinguished in both cases. These findings were interpreted as showing that Tay-Sachs disease is caused by the degeneration of ganglion cells in the nervous system and that the ganglion cells in the retina do not affect the ERGs of vertebrate animals.

Cerebral Cortex↗