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Biomedical subjects

M Strohm

Publications and source records attributed to M Strohm.

35 records · Page 2Linked to original sources

[Aspergilloma of the sphenoid sinus with aspergillus meningitis (author's transl)].

A man of 74 years of age, suffering from a left-sided ophthalmoplegia and a radiologically detected opacification of the sphenoid sinus with destruction of the bony roof of the sphenoid sinus, was operated on because a malignant tumor was suspected. A destruction of the bony walls of the sphenoid sinus was found. The histological examination of the "glue"-like "tumorous" material revealed an aspergillosis. The patient developed an aspesrgillus meningitis postoperatively. Intrathecally administered Amphotericin B led to an improvement of the meningitis, but caused a fatal renal failure. A review of the literature showed that only 7 cases of aspergillosis of the sphenoid sinus have been reported, 3 of which presented with a tumor-like destruction of the sinus. An aspergilloma of the sphenoid sinus is therefore a rare but important differential diagnosis in patients with a suspected malignancy of the infrasellar region.

Aged↗

[Pathogenesis of chronic recurrent parotitis (author's transl)].

A combination of several factors is of importance in the pathogenesis of sialectatic parotitis. Stenson's duct is relatively long and its orifice is narrow. The flow of the saliva may be impaired, especially when mastication is abnormal or when the ductal lumen is scarred because of infection or trauma. Dental or oral mucosal disease may increase the number of pathogenic organisms which might then lead to a retrograde ascending infection. This is followed by epithelial desquamation and subsequent ductal obstruction. Allergic, genetic an racial factors in sialectatic parotitis are also discussed. The four characteristic progressive histologic stages of sialectatic parotitis are: a periductal inflammatory reaction, a diffuse lymphocytic sialadenitis with dilated ducts, fully developed sialectatic parotitis and, finally, fibrosis of the parotid gland. Conservative treatment will lead to an improvement of the clinical symptoms as well as the histopathological features in the first two stages, but in the two final stages total parotidectomy, with preservation of the facial nerve, is the treatment of choice.

Adolescent↗

[Lesions of round window membrane].

In 15 cases, a rupture of the round window membrane could be found via exploratory tympanotomy. The main sign in these cases was an inner ear deafness; vertigo and tinnitus were less frequent. These findings correspond well with reports in the literature. Since there is no specific clinical sign of a ruptured membrane, tympanotomy is necessary in all suspicious cases. Chances of restoration or maintenance of hearing are high in cases of early repair of the fistula, but prospects diminish as the time interval between injury and repair increases. Vertigo and tinnitus disappear even by a delayed operation. The healing process of the round window membrane and the pathological changes in the round window niche after ruptured membrane were studied in guinea pigs. To evaluate the relationship between round window membrane rupture and blunt head injury, 87 temporal bones were studied after a fatal head injury.

Animals↗

[Results in the treatment of tongue cancer].

Hundred and four patients with a carcinoma of the tongue were seen at the ENT-clinic of Tübingen between 1969 and 1979. Most of them had advanced tumors, which were treated by a combined surgical and radiological therapy or by surgery or radiotherapy alone. There were a clearcut relationship between the prognosis and the histology, the stade and the localization of the tumor. Best therapeutic results were seen after the combined surgical and radiological therapy, especially in the treatment of neck metastases. Recurrencies of neck metastases were effectively treated by surgery; the fate of the patients depended on the primary tumor and on the occurrence of distant metastases.

Adult↗

[The effect of Urografin on sensorineural deafness. A clinical study (author's transl)].

Prof. Morimitsu (Fukuoka, Japan) reported a case of hearing improvement after the intravenous administration of Urografin in 1976. Because we had a similar case, injected 10 ml of Urografin (76%) intravenously in 130 patients with sensorineural deafness and tinnitus, which had not improved with previous treatment consisting of vasodilators and stellate ganglion blocks. 21 patients had a hearing improvement after Urografin-therapy; the tinnitus disappeared in 8 cases, and 2 patients noticed an improvement of their hearing and tinnitus. No adverse reactions to these injections, except for one case with a mild cutaneous allergy, were observed. The data did not reveal any particular clinical or audiological criteria which indicated a favourable prognosis with Urografin-therapy.

Deafness↗

Treatment of a recurrent choanal atresia by balloon dilatation.

A 16-year-old female patient with recurrent stenosis after unilateral choanal atresia that had been treated by surgery and laser therapy presented with restenosis 3 weeks after laser resection. As an alternative to repeat surgery, she was treated by balloon dilatation. Four balloon dilatations were performed (three at 4-week intervals and the last after an 8-week interval) over a 4-month period on an outpatient basis. She tolerated the treatment well without any complications. Over a follow-up period of 2 years the choana has remained completely open. The balloon dilatation described in this context here for the first time may be a good alternative to repeated operations in the treatment of recurrent choanal atresia, with minimal stress to the patient.

Adolescent↗

A pilot study: locus of control and spiritual beliefs in alcoholics anonymous and smart recovery members.

To investigate whether Alcoholics Anonymous' (AA's) "higher power" concept encourages externally dependent behavior, this pilot study tested whether AA and Self Management and Recovery Training (SR) members are equal on measures of external locus of control. The AA sample (N = 48) and SR sample (N = 33) were similar in age, gender, and education levels, and both required a minimum of 8 weeks group involvement. A modified spiritual beliefs questionnaire (SBQ) was first administered to each sample to compare them on spiritual beliefs, and the drinking-related locus of control scale (DRIE) was then conducted to compare each sample on locus of control. Significant differences were found between both samples on five out of seven spiritual measures, with the AA group scoring consistently higher on these factors (p < .01). In addition, the AA sample was significantly more external on the DRIE scale than the SR sample (p = .00003). These findings suggest that AA members are generally more spiritually oriented and exhibit greater external locus of control relative to SR members. Future controlled trials are necessary to confirm whether these results are caused by particular programs or primarily due to a self-selective process.

Adult↗

Nitinol esophageal stents: new designs and clinical indications.

PURPOSE: To evaluate the clinical use of covered and noncovered, knitted nitinol stents in patients presenting new stent indications. METHODS: Self-expandable, knitted nitinol stents were implanted in four patients for treatment of dysphagia. In two patients who had malignant strictures and had esophago-respiratory fistulae and in one patient with an esophagocutaneous fistula, polytetrafluoroethylene (PTFE)-covered stents were implanted. One patient received a noncovered stent, but a retrograde approach through a percutaneous endoscopic gastrostomy (PEG) fistula had to be chosen for recanalization of an esophageal occlusion. Two patients received stents for treatment of benign strictures. RESULTS: Recanalization of the stricture and stent implantation were performed under fluoroscopic control without any procedure-related morbidity or mortality. Dysphagia improved in all patients and the esophageal fistulae could be sealed off by covered stents. During a maximum follow-up of 18 months, there was no stent migration or esophageal perforation. Complications observed were stent stenosis due to food impaction (1/4) and benign stent stenosis (2/2). Most complications could be treated by the interventional radiologist. CONCLUSION: Self-expandable, covered Nitinol stents provide an option for the treatment of dysphagia combined with esophageal fistulae. In combination with interventional radiology techniques, even complex strictures are accessible. For benign strictures, the value of stent treatment has not yet been proven.

Adult↗